HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains

Early steps of HIV infection of primary human cells remain poorly understood. Here, Francis et al. show that early viral replication complexes accumulate within nuclear speckles, in reliance on viral capsid/host CPSF6 interactions, and preferentially integrate in speckle-associated genomic domains.

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Autores principales:	Ashwanth C. Francis, Mariana Marin, Parmit K. Singh, Vasudevan Achuthan, Mathew J. Prellberg, Kristina Palermino-Rowland, Shuiyun Lan, Philip R. Tedbury, Stefan G. Sarafianos, Alan N. Engelman, Gregory B. Melikyan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/32dd990260c242f794d380d0f1625892
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spelling	oai:doaj.org-article:32dd990260c242f794d380d0f16258922021-12-02T17:01:15ZHIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains10.1038/s41467-020-17256-82041-1723https://doaj.org/article/32dd990260c242f794d380d0f16258922020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17256-8https://doaj.org/toc/2041-1723Early steps of HIV infection of primary human cells remain poorly understood. Here, Francis et al. show that early viral replication complexes accumulate within nuclear speckles, in reliance on viral capsid/host CPSF6 interactions, and preferentially integrate in speckle-associated genomic domains.Ashwanth C. FrancisMariana MarinParmit K. SinghVasudevan AchuthanMathew J. PrellbergKristina Palermino-RowlandShuiyun LanPhilip R. TedburyStefan G. SarafianosAlan N. EngelmanGregory B. MelikyanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ashwanth C. Francis Mariana Marin Parmit K. Singh Vasudevan Achuthan Mathew J. Prellberg Kristina Palermino-Rowland Shuiyun Lan Philip R. Tedbury Stefan G. Sarafianos Alan N. Engelman Gregory B. Melikyan HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains
description	Early steps of HIV infection of primary human cells remain poorly understood. Here, Francis et al. show that early viral replication complexes accumulate within nuclear speckles, in reliance on viral capsid/host CPSF6 interactions, and preferentially integrate in speckle-associated genomic domains.
format	article
author	Ashwanth C. Francis Mariana Marin Parmit K. Singh Vasudevan Achuthan Mathew J. Prellberg Kristina Palermino-Rowland Shuiyun Lan Philip R. Tedbury Stefan G. Sarafianos Alan N. Engelman Gregory B. Melikyan
author_facet	Ashwanth C. Francis Mariana Marin Parmit K. Singh Vasudevan Achuthan Mathew J. Prellberg Kristina Palermino-Rowland Shuiyun Lan Philip R. Tedbury Stefan G. Sarafianos Alan N. Engelman Gregory B. Melikyan
author_sort	Ashwanth C. Francis
title	HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains
title_short	HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains
title_full	HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains
title_fullStr	HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains
title_full_unstemmed	HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains
title_sort	hiv-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/32dd990260c242f794d380d0f1625892
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HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains

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