IgE-activated mast cells enhance TLR4-mediated antigen-specific CD4+ T cell responses

Abstract Mast cells are potent mediators of allergy and asthma, yet their role in regulating adaptive immunity remains ambiguous. On the surface of mast cells, the crosslinking of IgE bound to FcεRI by a specific antigen recognized by that IgE triggers the release of immune mediators such as histami...

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Autores principales:	Binh L. Phong, Shaina J. D’Souza, Robin L. Baudier, Eric Wu, Victoria E. Immethun, David L. Bauer, James B. McLachlan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/32e9ca69d1884b0986078bf9e4464819
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spelling	oai:doaj.org-article:32e9ca69d1884b0986078bf9e44648192021-12-02T14:29:15ZIgE-activated mast cells enhance TLR4-mediated antigen-specific CD4+ T cell responses10.1038/s41598-021-88956-42045-2322https://doaj.org/article/32e9ca69d1884b0986078bf9e44648192021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88956-4https://doaj.org/toc/2045-2322Abstract Mast cells are potent mediators of allergy and asthma, yet their role in regulating adaptive immunity remains ambiguous. On the surface of mast cells, the crosslinking of IgE bound to FcεRI by a specific antigen recognized by that IgE triggers the release of immune mediators such as histamine and cytokines capable of activating other immune cells; however, little is known about the mast cell contribution to the induction of endogenous, antigen-specific CD4+ T cells. Here we examined the effects of specific mast cell activation in vivo on the initiation of an antigen-specific CD4+ T cell response. While CD4+ T cells were not enhanced by FcεRI stimulation alone, their activation was synergistically enhanced when FcεRI activation was combined with TLR4 stimulation. This enhanced activation was dependent on global TLR4 stimulation but appeared to be less dependent on mast cell expressed TLR4. This study provides important new evidence to support the role of mast cells as mediators of the antigen-specific adaptive immune response.Binh L. PhongShaina J. D’SouzaRobin L. BaudierEric WuVictoria E. ImmethunDavid L. BauerJames B. McLachlanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Binh L. Phong Shaina J. D’Souza Robin L. Baudier Eric Wu Victoria E. Immethun David L. Bauer James B. McLachlan IgE-activated mast cells enhance TLR4-mediated antigen-specific CD4+ T cell responses
description	Abstract Mast cells are potent mediators of allergy and asthma, yet their role in regulating adaptive immunity remains ambiguous. On the surface of mast cells, the crosslinking of IgE bound to FcεRI by a specific antigen recognized by that IgE triggers the release of immune mediators such as histamine and cytokines capable of activating other immune cells; however, little is known about the mast cell contribution to the induction of endogenous, antigen-specific CD4+ T cells. Here we examined the effects of specific mast cell activation in vivo on the initiation of an antigen-specific CD4+ T cell response. While CD4+ T cells were not enhanced by FcεRI stimulation alone, their activation was synergistically enhanced when FcεRI activation was combined with TLR4 stimulation. This enhanced activation was dependent on global TLR4 stimulation but appeared to be less dependent on mast cell expressed TLR4. This study provides important new evidence to support the role of mast cells as mediators of the antigen-specific adaptive immune response.
format	article
author	Binh L. Phong Shaina J. D’Souza Robin L. Baudier Eric Wu Victoria E. Immethun David L. Bauer James B. McLachlan
author_facet	Binh L. Phong Shaina J. D’Souza Robin L. Baudier Eric Wu Victoria E. Immethun David L. Bauer James B. McLachlan
author_sort	Binh L. Phong
title	IgE-activated mast cells enhance TLR4-mediated antigen-specific CD4+ T cell responses
title_short	IgE-activated mast cells enhance TLR4-mediated antigen-specific CD4+ T cell responses
title_full	IgE-activated mast cells enhance TLR4-mediated antigen-specific CD4+ T cell responses
title_fullStr	IgE-activated mast cells enhance TLR4-mediated antigen-specific CD4+ T cell responses
title_full_unstemmed	IgE-activated mast cells enhance TLR4-mediated antigen-specific CD4+ T cell responses
title_sort	ige-activated mast cells enhance tlr4-mediated antigen-specific cd4+ t cell responses
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/32e9ca69d1884b0986078bf9e4464819
work_keys_str_mv	AT binhlphong igeactivatedmastcellsenhancetlr4mediatedantigenspecificcd4tcellresponses AT shainajdsouza igeactivatedmastcellsenhancetlr4mediatedantigenspecificcd4tcellresponses AT robinlbaudier igeactivatedmastcellsenhancetlr4mediatedantigenspecificcd4tcellresponses AT ericwu igeactivatedmastcellsenhancetlr4mediatedantigenspecificcd4tcellresponses AT victoriaeimmethun igeactivatedmastcellsenhancetlr4mediatedantigenspecificcd4tcellresponses AT davidlbauer igeactivatedmastcellsenhancetlr4mediatedantigenspecificcd4tcellresponses AT jamesbmclachlan igeactivatedmastcellsenhancetlr4mediatedantigenspecificcd4tcellresponses
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IgE-activated mast cells enhance TLR4-mediated antigen-specific CD4+ T cell responses

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