Post-correlation on-lamella cryo-CLEM reveals the membrane architecture of lamellar bodies

Using the post-correlation on-lamella cryo-CLEM workflow, Klein, Wimmer et al. show that lamellar bodies (LBs) are composed of membrane sheets frequently attached to the limiting membrane through T-junctions in ABCA3 overexpressing cells and in primary human small airway epithelial cells. This study...

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Autores principales:	Steffen Klein, Benedikt H. Wimmer, Sophie L. Winter, Androniki Kolovou, Vibor Laketa, Petr Chlanda
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/32ea53411acf49449270aa8a27ac4173
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spelling	oai:doaj.org-article:32ea53411acf49449270aa8a27ac41732021-12-02T10:47:53ZPost-correlation on-lamella cryo-CLEM reveals the membrane architecture of lamellar bodies10.1038/s42003-020-01567-z2399-3642https://doaj.org/article/32ea53411acf49449270aa8a27ac41732021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01567-zhttps://doaj.org/toc/2399-3642Using the post-correlation on-lamella cryo-CLEM workflow, Klein, Wimmer et al. show that lamellar bodies (LBs) are composed of membrane sheets frequently attached to the limiting membrane through T-junctions in ABCA3 overexpressing cells and in primary human small airway epithelial cells. This study provides insights into LB biogenesis and membrane packing inside the LB.Steffen KleinBenedikt H. WimmerSophie L. WinterAndroniki KolovouVibor LaketaPetr ChlandaNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Steffen Klein Benedikt H. Wimmer Sophie L. Winter Androniki Kolovou Vibor Laketa Petr Chlanda Post-correlation on-lamella cryo-CLEM reveals the membrane architecture of lamellar bodies
description	Using the post-correlation on-lamella cryo-CLEM workflow, Klein, Wimmer et al. show that lamellar bodies (LBs) are composed of membrane sheets frequently attached to the limiting membrane through T-junctions in ABCA3 overexpressing cells and in primary human small airway epithelial cells. This study provides insights into LB biogenesis and membrane packing inside the LB.
format	article
author	Steffen Klein Benedikt H. Wimmer Sophie L. Winter Androniki Kolovou Vibor Laketa Petr Chlanda
author_facet	Steffen Klein Benedikt H. Wimmer Sophie L. Winter Androniki Kolovou Vibor Laketa Petr Chlanda
author_sort	Steffen Klein
title	Post-correlation on-lamella cryo-CLEM reveals the membrane architecture of lamellar bodies
title_short	Post-correlation on-lamella cryo-CLEM reveals the membrane architecture of lamellar bodies
title_full	Post-correlation on-lamella cryo-CLEM reveals the membrane architecture of lamellar bodies
title_fullStr	Post-correlation on-lamella cryo-CLEM reveals the membrane architecture of lamellar bodies
title_full_unstemmed	Post-correlation on-lamella cryo-CLEM reveals the membrane architecture of lamellar bodies
title_sort	post-correlation on-lamella cryo-clem reveals the membrane architecture of lamellar bodies
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/32ea53411acf49449270aa8a27ac4173
work_keys_str_mv	AT steffenklein postcorrelationonlamellacryoclemrevealsthemembranearchitectureoflamellarbodies AT benedikthwimmer postcorrelationonlamellacryoclemrevealsthemembranearchitectureoflamellarbodies AT sophielwinter postcorrelationonlamellacryoclemrevealsthemembranearchitectureoflamellarbodies AT andronikikolovou postcorrelationonlamellacryoclemrevealsthemembranearchitectureoflamellarbodies AT viborlaketa postcorrelationonlamellacryoclemrevealsthemembranearchitectureoflamellarbodies AT petrchlanda postcorrelationonlamellacryoclemrevealsthemembranearchitectureoflamellarbodies
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Post-correlation on-lamella cryo-CLEM reveals the membrane architecture of lamellar bodies

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