Quantitative Proteomics Analysis of Plasmodium vivax Induced Alterations in Human Serum during the Acute and Convalescent Phases of Infection

Abstract The radial distribution of Plasmodium vivax malaria burden has evoked enormous concern among the global research community. In this study, we have investigated the serum proteome alterations in non-severe vivax malaria patients before and during patient recuperation starting from the early...

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Autores principales:	Sandipan Ray, Sandip K. Patel, Apoorva Venkatesh, Gangadhar Chatterjee, Naziya N. Ansari, Nithya J. Gogtay, Urmila M. Thatte, Prajakta Gandhe, Santosh G. Varma, Swati Patankar, Sanjeeva Srivastava
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/32eefee394b5458588d7695f41dbf5f1
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spelling	oai:doaj.org-article:32eefee394b5458588d7695f41dbf5f12021-12-02T16:05:59ZQuantitative Proteomics Analysis of Plasmodium vivax Induced Alterations in Human Serum during the Acute and Convalescent Phases of Infection10.1038/s41598-017-04447-52045-2322https://doaj.org/article/32eefee394b5458588d7695f41dbf5f12017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04447-5https://doaj.org/toc/2045-2322Abstract The radial distribution of Plasmodium vivax malaria burden has evoked enormous concern among the global research community. In this study, we have investigated the serum proteome alterations in non-severe vivax malaria patients before and during patient recuperation starting from the early febrile to the defervescence and convalescent stages of the infection. We have also performed an extensive quantitative proteomics analysis to compare the serum proteome profiles of vivax malaria patients with low (LPVM) and moderately-high (MPVM) parasitemia with healthy community controls. Interestingly, some of the serum proteins such as Serum amyloid A, Apolipoprotein A1, C-reactive protein, Titin and Haptoglobin, were found to be sequentially altered with respect to increased parasite counts. Analysis of a longitudinal cohort of malaria patients indicated reversible alterations in serum levels of some proteins such as Haptoglobin, Apolipoprotein E, Apolipoprotein A1, Carbonic anhydrase 1, and Hemoglobin subunit alpha upon treatment; however, the levels of a few other proteins did not return to the baseline even during the convalescent phase of the infection. Here we present the first comprehensive serum proteomics analysis of vivax malaria patients with different levels of parasitemia and during the acute and convalescent phases of the infection.Sandipan RaySandip K. PatelApoorva VenkateshGangadhar ChatterjeeNaziya N. AnsariNithya J. GogtayUrmila M. ThattePrajakta GandheSantosh G. VarmaSwati PatankarSanjeeva SrivastavaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sandipan Ray Sandip K. Patel Apoorva Venkatesh Gangadhar Chatterjee Naziya N. Ansari Nithya J. Gogtay Urmila M. Thatte Prajakta Gandhe Santosh G. Varma Swati Patankar Sanjeeva Srivastava Quantitative Proteomics Analysis of Plasmodium vivax Induced Alterations in Human Serum during the Acute and Convalescent Phases of Infection
description	Abstract The radial distribution of Plasmodium vivax malaria burden has evoked enormous concern among the global research community. In this study, we have investigated the serum proteome alterations in non-severe vivax malaria patients before and during patient recuperation starting from the early febrile to the defervescence and convalescent stages of the infection. We have also performed an extensive quantitative proteomics analysis to compare the serum proteome profiles of vivax malaria patients with low (LPVM) and moderately-high (MPVM) parasitemia with healthy community controls. Interestingly, some of the serum proteins such as Serum amyloid A, Apolipoprotein A1, C-reactive protein, Titin and Haptoglobin, were found to be sequentially altered with respect to increased parasite counts. Analysis of a longitudinal cohort of malaria patients indicated reversible alterations in serum levels of some proteins such as Haptoglobin, Apolipoprotein E, Apolipoprotein A1, Carbonic anhydrase 1, and Hemoglobin subunit alpha upon treatment; however, the levels of a few other proteins did not return to the baseline even during the convalescent phase of the infection. Here we present the first comprehensive serum proteomics analysis of vivax malaria patients with different levels of parasitemia and during the acute and convalescent phases of the infection.
format	article
author	Sandipan Ray Sandip K. Patel Apoorva Venkatesh Gangadhar Chatterjee Naziya N. Ansari Nithya J. Gogtay Urmila M. Thatte Prajakta Gandhe Santosh G. Varma Swati Patankar Sanjeeva Srivastava
author_facet	Sandipan Ray Sandip K. Patel Apoorva Venkatesh Gangadhar Chatterjee Naziya N. Ansari Nithya J. Gogtay Urmila M. Thatte Prajakta Gandhe Santosh G. Varma Swati Patankar Sanjeeva Srivastava
author_sort	Sandipan Ray
title	Quantitative Proteomics Analysis of Plasmodium vivax Induced Alterations in Human Serum during the Acute and Convalescent Phases of Infection
title_short	Quantitative Proteomics Analysis of Plasmodium vivax Induced Alterations in Human Serum during the Acute and Convalescent Phases of Infection
title_full	Quantitative Proteomics Analysis of Plasmodium vivax Induced Alterations in Human Serum during the Acute and Convalescent Phases of Infection
title_fullStr	Quantitative Proteomics Analysis of Plasmodium vivax Induced Alterations in Human Serum during the Acute and Convalescent Phases of Infection
title_full_unstemmed	Quantitative Proteomics Analysis of Plasmodium vivax Induced Alterations in Human Serum during the Acute and Convalescent Phases of Infection
title_sort	quantitative proteomics analysis of plasmodium vivax induced alterations in human serum during the acute and convalescent phases of infection
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/32eefee394b5458588d7695f41dbf5f1
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Quantitative Proteomics Analysis of Plasmodium vivax Induced Alterations in Human Serum during the Acute and Convalescent Phases of Infection

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