Human endogenous retrovirus protein activates innate immunity and promotes experimental allergic encephalomyelitis in mice.
Multiple sclerosis (MS) is a complex multifactorial disease of the central nervous system (CNS) for which animal models have mainly addressed downstream immunopathology but not potential inducers of autoimmunity. In the absence of a pathogen known to cause neuroinflammation in MS, Mycobacterial lysa...
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2013
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oai:doaj.org-article:32f3919b696a4600af910addc64f022e2021-11-18T08:43:12ZHuman endogenous retrovirus protein activates innate immunity and promotes experimental allergic encephalomyelitis in mice.1932-620310.1371/journal.pone.0080128https://doaj.org/article/32f3919b696a4600af910addc64f022e2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24324591/?tool=EBIhttps://doaj.org/toc/1932-6203Multiple sclerosis (MS) is a complex multifactorial disease of the central nervous system (CNS) for which animal models have mainly addressed downstream immunopathology but not potential inducers of autoimmunity. In the absence of a pathogen known to cause neuroinflammation in MS, Mycobacterial lysate is commonly used in the form of complete Freund's adjuvant to induce autoimmunity to myelin proteins in Experimental Allergic Encephalomyelitis (EAE), an animal model for MS. The present study demonstrates that a protein from the human endogenous retrovirus HERV-W family (MSRV-Env) can be used instead of mycobacterial lysate to induce autoimmunity and EAE in mice injected with MOG, with typical anti-myelin response and CNS lesions normally seen in this model. MSRV-Env was shown to induce proinflammatory response in human macrophage cells through TLR4 activation pathway. The present results demonstrate a similar activation of murine dendritic cells and show the ability of MSRV-Env to trigger EAE in mice. In previous studies, MSRV-Env protein was reproducibly detected in MS brain lesions within microglia and perivascular macrophages. The present results are therefore likely to provide a model for MS, in which the upstream adjuvant triggering neuroinflammation is the one detected in MS active lesions. This model now allows pre-clinical studies with therapeutic agents targeting this endogenous retroviral protein in MS.Hervé PerronHei-Lanne Dougier-ReynaudChristina LomparskiIuliana PopaReza FirouziJean-Baptiste BertrandSuzana MarusicJacques PortoukalianEvelyne Jouvin-MarcheChristian L VilliersJean-Louis TourainePatrice N MarchePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e80128 (2013) |
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Medicine R Science Q |
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Medicine R Science Q Hervé Perron Hei-Lanne Dougier-Reynaud Christina Lomparski Iuliana Popa Reza Firouzi Jean-Baptiste Bertrand Suzana Marusic Jacques Portoukalian Evelyne Jouvin-Marche Christian L Villiers Jean-Louis Touraine Patrice N Marche Human endogenous retrovirus protein activates innate immunity and promotes experimental allergic encephalomyelitis in mice. |
| description |
Multiple sclerosis (MS) is a complex multifactorial disease of the central nervous system (CNS) for which animal models have mainly addressed downstream immunopathology but not potential inducers of autoimmunity. In the absence of a pathogen known to cause neuroinflammation in MS, Mycobacterial lysate is commonly used in the form of complete Freund's adjuvant to induce autoimmunity to myelin proteins in Experimental Allergic Encephalomyelitis (EAE), an animal model for MS. The present study demonstrates that a protein from the human endogenous retrovirus HERV-W family (MSRV-Env) can be used instead of mycobacterial lysate to induce autoimmunity and EAE in mice injected with MOG, with typical anti-myelin response and CNS lesions normally seen in this model. MSRV-Env was shown to induce proinflammatory response in human macrophage cells through TLR4 activation pathway. The present results demonstrate a similar activation of murine dendritic cells and show the ability of MSRV-Env to trigger EAE in mice. In previous studies, MSRV-Env protein was reproducibly detected in MS brain lesions within microglia and perivascular macrophages. The present results are therefore likely to provide a model for MS, in which the upstream adjuvant triggering neuroinflammation is the one detected in MS active lesions. This model now allows pre-clinical studies with therapeutic agents targeting this endogenous retroviral protein in MS. |
| format |
article |
| author |
Hervé Perron Hei-Lanne Dougier-Reynaud Christina Lomparski Iuliana Popa Reza Firouzi Jean-Baptiste Bertrand Suzana Marusic Jacques Portoukalian Evelyne Jouvin-Marche Christian L Villiers Jean-Louis Touraine Patrice N Marche |
| author_facet |
Hervé Perron Hei-Lanne Dougier-Reynaud Christina Lomparski Iuliana Popa Reza Firouzi Jean-Baptiste Bertrand Suzana Marusic Jacques Portoukalian Evelyne Jouvin-Marche Christian L Villiers Jean-Louis Touraine Patrice N Marche |
| author_sort |
Hervé Perron |
| title |
Human endogenous retrovirus protein activates innate immunity and promotes experimental allergic encephalomyelitis in mice. |
| title_short |
Human endogenous retrovirus protein activates innate immunity and promotes experimental allergic encephalomyelitis in mice. |
| title_full |
Human endogenous retrovirus protein activates innate immunity and promotes experimental allergic encephalomyelitis in mice. |
| title_fullStr |
Human endogenous retrovirus protein activates innate immunity and promotes experimental allergic encephalomyelitis in mice. |
| title_full_unstemmed |
Human endogenous retrovirus protein activates innate immunity and promotes experimental allergic encephalomyelitis in mice. |
| title_sort |
human endogenous retrovirus protein activates innate immunity and promotes experimental allergic encephalomyelitis in mice. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/32f3919b696a4600af910addc64f022e |
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