Distribution of inhaled volatile β-caryophyllene and dynamic changes of liver metabolites in mice

Abstract β-caryophyllene (BCP), an essential oil component of many herbs and spices, has various biological activities as a functional food factor. A distinct feature of BCP is its volatile double-ring sesquiterpene structure. Orally administered BCP is reportedly detected in its intact form in mice...

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Autores principales:	Yuki Takemoto, Chihiro Kishi, Yuki Sugiura, Yuri Yoshioka, Shinichi Matsumura, Tatsuya Moriyama, Nobuhiro Zaima
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/32f668ecb5db49eda0afd9445ebedb22
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spelling	oai:doaj.org-article:32f668ecb5db49eda0afd9445ebedb222021-12-02T11:50:30ZDistribution of inhaled volatile β-caryophyllene and dynamic changes of liver metabolites in mice10.1038/s41598-021-81181-z2045-2322https://doaj.org/article/32f668ecb5db49eda0afd9445ebedb222021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81181-zhttps://doaj.org/toc/2045-2322Abstract β-caryophyllene (BCP), an essential oil component of many herbs and spices, has various biological activities as a functional food factor. A distinct feature of BCP is its volatile double-ring sesquiterpene structure. Orally administered BCP is reportedly detected in its intact form in mice serum; however, the distribution of inhaled volatile BCP throughout the body remains unknown. This study aimed to estimate the distribution properties of inhaled volatile BCP and to investigate its effects on metabolism. After mice were exposed to volatile BCP, it was detected in the lung, olfactory bulb, brain, serum, heart, liver, kidney, epididymal fat, and brown adipose tissue. BCP was further detected in the brain, liver, and brown adipose tissue 24 h after exposure. Metabolites related to glutathione metabolism were significantly altered in the liver. These results suggest that inhaled volatile BCP is widely distributed in murine tissues and affects the dynamics of metabolites in the liver.Yuki TakemotoChihiro KishiYuki SugiuraYuri YoshiokaShinichi MatsumuraTatsuya MoriyamaNobuhiro ZaimaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuki Takemoto Chihiro Kishi Yuki Sugiura Yuri Yoshioka Shinichi Matsumura Tatsuya Moriyama Nobuhiro Zaima Distribution of inhaled volatile β-caryophyllene and dynamic changes of liver metabolites in mice
description	Abstract β-caryophyllene (BCP), an essential oil component of many herbs and spices, has various biological activities as a functional food factor. A distinct feature of BCP is its volatile double-ring sesquiterpene structure. Orally administered BCP is reportedly detected in its intact form in mice serum; however, the distribution of inhaled volatile BCP throughout the body remains unknown. This study aimed to estimate the distribution properties of inhaled volatile BCP and to investigate its effects on metabolism. After mice were exposed to volatile BCP, it was detected in the lung, olfactory bulb, brain, serum, heart, liver, kidney, epididymal fat, and brown adipose tissue. BCP was further detected in the brain, liver, and brown adipose tissue 24 h after exposure. Metabolites related to glutathione metabolism were significantly altered in the liver. These results suggest that inhaled volatile BCP is widely distributed in murine tissues and affects the dynamics of metabolites in the liver.
format	article
author	Yuki Takemoto Chihiro Kishi Yuki Sugiura Yuri Yoshioka Shinichi Matsumura Tatsuya Moriyama Nobuhiro Zaima
author_facet	Yuki Takemoto Chihiro Kishi Yuki Sugiura Yuri Yoshioka Shinichi Matsumura Tatsuya Moriyama Nobuhiro Zaima
author_sort	Yuki Takemoto
title	Distribution of inhaled volatile β-caryophyllene and dynamic changes of liver metabolites in mice
title_short	Distribution of inhaled volatile β-caryophyllene and dynamic changes of liver metabolites in mice
title_full	Distribution of inhaled volatile β-caryophyllene and dynamic changes of liver metabolites in mice
title_fullStr	Distribution of inhaled volatile β-caryophyllene and dynamic changes of liver metabolites in mice
title_full_unstemmed	Distribution of inhaled volatile β-caryophyllene and dynamic changes of liver metabolites in mice
title_sort	distribution of inhaled volatile β-caryophyllene and dynamic changes of liver metabolites in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/32f668ecb5db49eda0afd9445ebedb22
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Distribution of inhaled volatile β-caryophyllene and dynamic changes of liver metabolites in mice

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