Tissue Engineering Meets Nanotechnology: Molecular Mechanism Modulations in Cornea Regeneration

Nowadays, tissue engineering is one of the most promising approaches for the regeneration of various tissues and organs, including the cornea. However, the inability of biomaterial scaffolds to successfully integrate into the environment of surrounding tissues is one of the main challenges that suff...

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Auteurs principaux:	Olja Mijanović, Timofey Pylaev, Angelina Nikitkina, Margarita Artyukhova, Ana Branković, Maria Peshkova, Polina Bikmulina, Boris Turk, Sergey Bolevich, Sergei Avetisov, Peter Timashev
Format:	article
Langue:	EN
Publié:	MDPI AG 2021
Sujets:	cornea regeneration tissue engineering nanotechnology molecular mechanisms Mechanical engineering and machinery TJ1-1570
Accès en ligne:	https://doaj.org/article/32f84aae8f6e4d6895394a5b52b6255b
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spelling	oai:doaj.org-article:32f84aae8f6e4d6895394a5b52b6255b2021-11-25T18:23:15ZTissue Engineering Meets Nanotechnology: Molecular Mechanism Modulations in Cornea Regeneration10.3390/mi121113362072-666Xhttps://doaj.org/article/32f84aae8f6e4d6895394a5b52b6255b2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-666X/12/11/1336https://doaj.org/toc/2072-666XNowadays, tissue engineering is one of the most promising approaches for the regeneration of various tissues and organs, including the cornea. However, the inability of biomaterial scaffolds to successfully integrate into the environment of surrounding tissues is one of the main challenges that sufficiently limits the restoration of damaged corneal tissues. Thus, the modulation of molecular and cellular mechanisms is important and necessary for successful graft integration and long-term survival. The dynamics of molecular interactions affecting the site of injury will determine the corneal transplantation efficacy and the post-surgery clinical outcome. The interactions between biomaterial surfaces, cells and their microenvironment can regulate cell behavior and alter their physiology and signaling pathways. Nanotechnology is an advantageous tool for the current understanding, coordination, and directed regulation of molecular cell–transplant interactions on behalf of the healing of corneal wounds. Therefore, the use of various nanotechnological strategies will provide new solutions to the problem of corneal allograft rejection, by modulating and regulating host–graft interaction dynamics towards proper integration and long-term functionality of the transplant.Olja MijanovićTimofey PylaevAngelina NikitkinaMargarita ArtyukhovaAna BrankovićMaria PeshkovaPolina BikmulinaBoris TurkSergey BolevichSergei AvetisovPeter TimashevMDPI AGarticlecornea regenerationtissue engineeringnanotechnologymolecular mechanismsMechanical engineering and machineryTJ1-1570ENMicromachines, Vol 12, Iss 1336, p 1336 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cornea regeneration tissue engineering nanotechnology molecular mechanisms Mechanical engineering and machinery TJ1-1570
spellingShingle	cornea regeneration tissue engineering nanotechnology molecular mechanisms Mechanical engineering and machinery TJ1-1570 Olja Mijanović Timofey Pylaev Angelina Nikitkina Margarita Artyukhova Ana Branković Maria Peshkova Polina Bikmulina Boris Turk Sergey Bolevich Sergei Avetisov Peter Timashev Tissue Engineering Meets Nanotechnology: Molecular Mechanism Modulations in Cornea Regeneration
description	Nowadays, tissue engineering is one of the most promising approaches for the regeneration of various tissues and organs, including the cornea. However, the inability of biomaterial scaffolds to successfully integrate into the environment of surrounding tissues is one of the main challenges that sufficiently limits the restoration of damaged corneal tissues. Thus, the modulation of molecular and cellular mechanisms is important and necessary for successful graft integration and long-term survival. The dynamics of molecular interactions affecting the site of injury will determine the corneal transplantation efficacy and the post-surgery clinical outcome. The interactions between biomaterial surfaces, cells and their microenvironment can regulate cell behavior and alter their physiology and signaling pathways. Nanotechnology is an advantageous tool for the current understanding, coordination, and directed regulation of molecular cell–transplant interactions on behalf of the healing of corneal wounds. Therefore, the use of various nanotechnological strategies will provide new solutions to the problem of corneal allograft rejection, by modulating and regulating host–graft interaction dynamics towards proper integration and long-term functionality of the transplant.
format	article
author	Olja Mijanović Timofey Pylaev Angelina Nikitkina Margarita Artyukhova Ana Branković Maria Peshkova Polina Bikmulina Boris Turk Sergey Bolevich Sergei Avetisov Peter Timashev
author_facet	Olja Mijanović Timofey Pylaev Angelina Nikitkina Margarita Artyukhova Ana Branković Maria Peshkova Polina Bikmulina Boris Turk Sergey Bolevich Sergei Avetisov Peter Timashev
author_sort	Olja Mijanović
title	Tissue Engineering Meets Nanotechnology: Molecular Mechanism Modulations in Cornea Regeneration
title_short	Tissue Engineering Meets Nanotechnology: Molecular Mechanism Modulations in Cornea Regeneration
title_full	Tissue Engineering Meets Nanotechnology: Molecular Mechanism Modulations in Cornea Regeneration
title_fullStr	Tissue Engineering Meets Nanotechnology: Molecular Mechanism Modulations in Cornea Regeneration
title_full_unstemmed	Tissue Engineering Meets Nanotechnology: Molecular Mechanism Modulations in Cornea Regeneration
title_sort	tissue engineering meets nanotechnology: molecular mechanism modulations in cornea regeneration
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/32f84aae8f6e4d6895394a5b52b6255b
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Tissue Engineering Meets Nanotechnology: Molecular Mechanism Modulations in Cornea Regeneration

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