GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes

Carotid intima-media thickness (cIMT) and plaque are associated with subclinical atherosclerosis and coronary heart disease (CHD). Here, the authors identify and prioritize genetic loci for cIMT and plaque by GWAS and colocalization approaches and further demonstrate genetic correlation with CHD and...

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Autores principales:	Nora Franceschini, Claudia Giambartolomei, Paul S. de Vries, Chris Finan, Joshua C. Bis, Rachael P. Huntley, Ruth C. Lovering, Salman M. Tajuddin, Thomas W. Winkler, Misa Graff, Maryam Kavousi, Caroline Dale, Albert V. Smith, Edith Hofer, Elisabeth M. van Leeuwen, Ilja M. Nolte, Lingyi Lu, Markus Scholz, Muralidharan Sargurupremraj, Niina Pitkänen, Oscar Franzén, Peter K. Joshi, Raymond Noordam, Riccardo E. Marioni, Shih-Jen Hwang, Solomon K. Musani, Ulf Schminke, Walter Palmas, Aaron Isaacs, Adolfo Correa, Alan B. Zonderman, Albert Hofman, Alexander Teumer, Amanda J. Cox, André G. Uitterlinden, Andrew Wong, Andries J. Smit, Anne B. Newman, Annie Britton, Arno Ruusalepp, Bengt Sennblad, Bo Hedblad, Bogdan Pasaniuc, Brenda W. Penninx, Carl D. Langefeld, Christina L. Wassel, Christophe Tzourio, Cristiano Fava, Damiano Baldassarre, Daniel H. O’Leary, Daniel Teupser, Diana Kuh, Elena Tremoli, Elmo Mannarino, Enzo Grossi, Eric Boerwinkle, Eric E. Schadt, Erik Ingelsson, Fabrizio Veglia, Fernando Rivadeneira, Frank Beutner, Ganesh Chauhan, Gerardo Heiss, Harold Snieder, Harry Campbell, Henry Völzke, Hugh S. Markus, Ian J. Deary, J. Wouter Jukema, Jacqueline de Graaf, Jacqueline Price, Janne Pott, Jemma C. Hopewell, Jingjing Liang, Joachim Thiery, Jorgen Engmann, Karl Gertow, Kenneth Rice, Kent D. Taylor, Klodian Dhana, Lambertus A. L. M. Kiemeney, Lars Lind, Laura M. Raffield, Lenore J. Launer, Lesca M. Holdt, Marcus Dörr, Martin Dichgans, Matthew Traylor, Matthias Sitzer, Meena Kumari, Mika Kivimaki, Mike A. Nalls, Olle Melander, Olli Raitakari, Oscar H. Franco, Oscar L. Rueda-Ochoa, Panos Roussos, Peter H. Whincup, Philippe Amouyel, Philippe Giral, Pramod Anugu, Quenna Wong, Rainer Malik, Rainer Rauramaa, Ralph Burkhardt, Rebecca Hardy, Reinhold Schmidt, Renée de Mutsert, Richard W. Morris, Rona J. Strawbridge, S. Goya Wannamethee, Sara Hägg, Sonia Shah, Stela McLachlan, Stella Trompet, Sudha Seshadri, Sudhir Kurl, Susan R. Heckbert, Susan Ring, Tamara B. Harris, Terho Lehtimäki, Tessel E. Galesloot, Tina Shah, Ulf de Faire, Vincent Plagnol, Wayne D. Rosamond, Wendy Post, Xiaofeng Zhu, Xiaoling Zhang, Xiuqing Guo, Yasaman Saba, MEGASTROKE Consortium, Abbas Dehghan, Adrie Seldenrijk, Alanna C. Morrison, Anders Hamsten, Bruce M. Psaty, Cornelia M. van Duijn, Deborah A. Lawlor, Dennis O. Mook-Kanamori, Donald W. Bowden, Helena Schmidt, James F. Wilson, James G. Wilson, Jerome I. Rotter, Joanna M. Wardlaw, John Deanfield, Julian Halcox, Leo-Pekka Lyytikäinen, Markus Loeffler, Michele K. Evans, Stéphanie Debette, Steve E. Humphries, Uwe Völker, Vilmundur Gudnason, Aroon D. Hingorani, Johan L. M. Björkegren, Juan P. Casas, Christopher J. O’Donnell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/32fac89a43804269804a3e18ff002db4
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spelling	oai:doaj.org-article:32fac89a43804269804a3e18ff002db42021-12-02T16:57:00ZGWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes10.1038/s41467-018-07340-52041-1723https://doaj.org/article/32fac89a43804269804a3e18ff002db42018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07340-5https://doaj.org/toc/2041-1723Carotid intima-media thickness (cIMT) and plaque are associated with subclinical atherosclerosis and coronary heart disease (CHD). Here, the authors identify and prioritize genetic loci for cIMT and plaque by GWAS and colocalization approaches and further demonstrate genetic correlation with CHD and stroke.Nora FranceschiniClaudia GiambartolomeiPaul S. de VriesChris FinanJoshua C. BisRachael P. HuntleyRuth C. LoveringSalman M. TajuddinThomas W. WinklerMisa GraffMaryam KavousiCaroline DaleAlbert V. SmithEdith HoferElisabeth M. van LeeuwenIlja M. NolteLingyi LuMarkus ScholzMuralidharan SargurupremrajNiina PitkänenOscar FranzénPeter K. JoshiRaymond NoordamRiccardo E. MarioniShih-Jen HwangSolomon K. MusaniUlf SchminkeWalter PalmasAaron IsaacsAdolfo CorreaAlan B. ZondermanAlbert HofmanAlexander TeumerAmanda J. CoxAndré G. UitterlindenAndrew WongAndries J. SmitAnne B. NewmanAnnie BrittonArno RuusaleppBengt SennbladBo HedbladBogdan PasaniucBrenda W. PenninxCarl D. LangefeldChristina L. WasselChristophe TzourioCristiano FavaDamiano BaldassarreDaniel H. O’LearyDaniel TeupserDiana KuhElena TremoliElmo MannarinoEnzo GrossiEric BoerwinkleEric E. SchadtErik IngelssonFabrizio VegliaFernando RivadeneiraFrank BeutnerGanesh ChauhanGerardo HeissHarold SniederHarry CampbellHenry VölzkeHugh S. MarkusIan J. DearyJ. Wouter JukemaJacqueline de GraafJacqueline PriceJanne PottJemma C. HopewellJingjing LiangJoachim ThieryJorgen EngmannKarl GertowKenneth RiceKent D. TaylorKlodian DhanaLambertus A. L. M. KiemeneyLars LindLaura M. RaffieldLenore J. LaunerLesca M. HoldtMarcus DörrMartin DichgansMatthew TraylorMatthias SitzerMeena KumariMika KivimakiMike A. NallsOlle MelanderOlli RaitakariOscar H. FrancoOscar L. Rueda-OchoaPanos RoussosPeter H. WhincupPhilippe AmouyelPhilippe GiralPramod AnuguQuenna WongRainer MalikRainer RauramaaRalph BurkhardtRebecca HardyReinhold SchmidtRenée de MutsertRichard W. MorrisRona J. StrawbridgeS. Goya WannametheeSara HäggSonia ShahStela McLachlanStella TrompetSudha SeshadriSudhir KurlSusan R. HeckbertSusan RingTamara B. HarrisTerho LehtimäkiTessel E. GaleslootTina ShahUlf de FaireVincent PlagnolWayne D. RosamondWendy PostXiaofeng ZhuXiaoling ZhangXiuqing GuoYasaman SabaMEGASTROKE ConsortiumAbbas DehghanAdrie SeldenrijkAlanna C. MorrisonAnders HamstenBruce M. PsatyCornelia M. van DuijnDeborah A. LawlorDennis O. Mook-KanamoriDonald W. BowdenHelena SchmidtJames F. WilsonJames G. WilsonJerome I. RotterJoanna M. WardlawJohn DeanfieldJulian HalcoxLeo-Pekka LyytikäinenMarkus LoefflerMichele K. EvansStéphanie DebetteSteve E. HumphriesUwe VölkerVilmundur GudnasonAroon D. HingoraniJohan L. M. BjörkegrenJuan P. CasasChristopher J. O’DonnellNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nora Franceschini Claudia Giambartolomei Paul S. de Vries Chris Finan Joshua C. Bis Rachael P. Huntley Ruth C. Lovering Salman M. Tajuddin Thomas W. Winkler Misa Graff Maryam Kavousi Caroline Dale Albert V. Smith Edith Hofer Elisabeth M. van Leeuwen Ilja M. Nolte Lingyi Lu Markus Scholz Muralidharan Sargurupremraj Niina Pitkänen Oscar Franzén Peter K. Joshi Raymond Noordam Riccardo E. Marioni Shih-Jen Hwang Solomon K. Musani Ulf Schminke Walter Palmas Aaron Isaacs Adolfo Correa Alan B. Zonderman Albert Hofman Alexander Teumer Amanda J. Cox André G. Uitterlinden Andrew Wong Andries J. Smit Anne B. Newman Annie Britton Arno Ruusalepp Bengt Sennblad Bo Hedblad Bogdan Pasaniuc Brenda W. Penninx Carl D. Langefeld Christina L. Wassel Christophe Tzourio Cristiano Fava Damiano Baldassarre Daniel H. O’Leary Daniel Teupser Diana Kuh Elena Tremoli Elmo Mannarino Enzo Grossi Eric Boerwinkle Eric E. Schadt Erik Ingelsson Fabrizio Veglia Fernando Rivadeneira Frank Beutner Ganesh Chauhan Gerardo Heiss Harold Snieder Harry Campbell Henry Völzke Hugh S. Markus Ian J. Deary J. Wouter Jukema Jacqueline de Graaf Jacqueline Price Janne Pott Jemma C. Hopewell Jingjing Liang Joachim Thiery Jorgen Engmann Karl Gertow Kenneth Rice Kent D. Taylor Klodian Dhana Lambertus A. L. M. Kiemeney Lars Lind Laura M. Raffield Lenore J. Launer Lesca M. Holdt Marcus Dörr Martin Dichgans Matthew Traylor Matthias Sitzer Meena Kumari Mika Kivimaki Mike A. Nalls Olle Melander Olli Raitakari Oscar H. Franco Oscar L. Rueda-Ochoa Panos Roussos Peter H. Whincup Philippe Amouyel Philippe Giral Pramod Anugu Quenna Wong Rainer Malik Rainer Rauramaa Ralph Burkhardt Rebecca Hardy Reinhold Schmidt Renée de Mutsert Richard W. Morris Rona J. Strawbridge S. Goya Wannamethee Sara Hägg Sonia Shah Stela McLachlan Stella Trompet Sudha Seshadri Sudhir Kurl Susan R. Heckbert Susan Ring Tamara B. Harris Terho Lehtimäki Tessel E. Galesloot Tina Shah Ulf de Faire Vincent Plagnol Wayne D. Rosamond Wendy Post Xiaofeng Zhu Xiaoling Zhang Xiuqing Guo Yasaman Saba MEGASTROKE Consortium Abbas Dehghan Adrie Seldenrijk Alanna C. Morrison Anders Hamsten Bruce M. Psaty Cornelia M. van Duijn Deborah A. Lawlor Dennis O. Mook-Kanamori Donald W. Bowden Helena Schmidt James F. Wilson James G. Wilson Jerome I. Rotter Joanna M. Wardlaw John Deanfield Julian Halcox Leo-Pekka Lyytikäinen Markus Loeffler Michele K. Evans Stéphanie Debette Steve E. Humphries Uwe Völker Vilmundur Gudnason Aroon D. Hingorani Johan L. M. Björkegren Juan P. Casas Christopher J. O’Donnell GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes
description	Carotid intima-media thickness (cIMT) and plaque are associated with subclinical atherosclerosis and coronary heart disease (CHD). Here, the authors identify and prioritize genetic loci for cIMT and plaque by GWAS and colocalization approaches and further demonstrate genetic correlation with CHD and stroke.
format	article
author	Nora Franceschini Claudia Giambartolomei Paul S. de Vries Chris Finan Joshua C. Bis Rachael P. Huntley Ruth C. Lovering Salman M. Tajuddin Thomas W. Winkler Misa Graff Maryam Kavousi Caroline Dale Albert V. Smith Edith Hofer Elisabeth M. van Leeuwen Ilja M. Nolte Lingyi Lu Markus Scholz Muralidharan Sargurupremraj Niina Pitkänen Oscar Franzén Peter K. Joshi Raymond Noordam Riccardo E. Marioni Shih-Jen Hwang Solomon K. Musani Ulf Schminke Walter Palmas Aaron Isaacs Adolfo Correa Alan B. Zonderman Albert Hofman Alexander Teumer Amanda J. Cox André G. Uitterlinden Andrew Wong Andries J. Smit Anne B. Newman Annie Britton Arno Ruusalepp Bengt Sennblad Bo Hedblad Bogdan Pasaniuc Brenda W. Penninx Carl D. Langefeld Christina L. Wassel Christophe Tzourio Cristiano Fava Damiano Baldassarre Daniel H. O’Leary Daniel Teupser Diana Kuh Elena Tremoli Elmo Mannarino Enzo Grossi Eric Boerwinkle Eric E. Schadt Erik Ingelsson Fabrizio Veglia Fernando Rivadeneira Frank Beutner Ganesh Chauhan Gerardo Heiss Harold Snieder Harry Campbell Henry Völzke Hugh S. Markus Ian J. Deary J. Wouter Jukema Jacqueline de Graaf Jacqueline Price Janne Pott Jemma C. Hopewell Jingjing Liang Joachim Thiery Jorgen Engmann Karl Gertow Kenneth Rice Kent D. Taylor Klodian Dhana Lambertus A. L. M. Kiemeney Lars Lind Laura M. Raffield Lenore J. Launer Lesca M. Holdt Marcus Dörr Martin Dichgans Matthew Traylor Matthias Sitzer Meena Kumari Mika Kivimaki Mike A. Nalls Olle Melander Olli Raitakari Oscar H. Franco Oscar L. Rueda-Ochoa Panos Roussos Peter H. Whincup Philippe Amouyel Philippe Giral Pramod Anugu Quenna Wong Rainer Malik Rainer Rauramaa Ralph Burkhardt Rebecca Hardy Reinhold Schmidt Renée de Mutsert Richard W. Morris Rona J. Strawbridge S. Goya Wannamethee Sara Hägg Sonia Shah Stela McLachlan Stella Trompet Sudha Seshadri Sudhir Kurl Susan R. Heckbert Susan Ring Tamara B. Harris Terho Lehtimäki Tessel E. Galesloot Tina Shah Ulf de Faire Vincent Plagnol Wayne D. Rosamond Wendy Post Xiaofeng Zhu Xiaoling Zhang Xiuqing Guo Yasaman Saba MEGASTROKE Consortium Abbas Dehghan Adrie Seldenrijk Alanna C. Morrison Anders Hamsten Bruce M. Psaty Cornelia M. van Duijn Deborah A. Lawlor Dennis O. Mook-Kanamori Donald W. Bowden Helena Schmidt James F. Wilson James G. Wilson Jerome I. Rotter Joanna M. Wardlaw John Deanfield Julian Halcox Leo-Pekka Lyytikäinen Markus Loeffler Michele K. Evans Stéphanie Debette Steve E. Humphries Uwe Völker Vilmundur Gudnason Aroon D. Hingorani Johan L. M. Björkegren Juan P. Casas Christopher J. O’Donnell
author_facet	Nora Franceschini Claudia Giambartolomei Paul S. de Vries Chris Finan Joshua C. Bis Rachael P. Huntley Ruth C. Lovering Salman M. Tajuddin Thomas W. Winkler Misa Graff Maryam Kavousi Caroline Dale Albert V. Smith Edith Hofer Elisabeth M. van Leeuwen Ilja M. Nolte Lingyi Lu Markus Scholz Muralidharan Sargurupremraj Niina Pitkänen Oscar Franzén Peter K. Joshi Raymond Noordam Riccardo E. Marioni Shih-Jen Hwang Solomon K. Musani Ulf Schminke Walter Palmas Aaron Isaacs Adolfo Correa Alan B. Zonderman Albert Hofman Alexander Teumer Amanda J. Cox André G. Uitterlinden Andrew Wong Andries J. Smit Anne B. Newman Annie Britton Arno Ruusalepp Bengt Sennblad Bo Hedblad Bogdan Pasaniuc Brenda W. Penninx Carl D. Langefeld Christina L. Wassel Christophe Tzourio Cristiano Fava Damiano Baldassarre Daniel H. O’Leary Daniel Teupser Diana Kuh Elena Tremoli Elmo Mannarino Enzo Grossi Eric Boerwinkle Eric E. Schadt Erik Ingelsson Fabrizio Veglia Fernando Rivadeneira Frank Beutner Ganesh Chauhan Gerardo Heiss Harold Snieder Harry Campbell Henry Völzke Hugh S. Markus Ian J. Deary J. Wouter Jukema Jacqueline de Graaf Jacqueline Price Janne Pott Jemma C. Hopewell Jingjing Liang Joachim Thiery Jorgen Engmann Karl Gertow Kenneth Rice Kent D. Taylor Klodian Dhana Lambertus A. L. M. Kiemeney Lars Lind Laura M. Raffield Lenore J. Launer Lesca M. Holdt Marcus Dörr Martin Dichgans Matthew Traylor Matthias Sitzer Meena Kumari Mika Kivimaki Mike A. Nalls Olle Melander Olli Raitakari Oscar H. Franco Oscar L. Rueda-Ochoa Panos Roussos Peter H. Whincup Philippe Amouyel Philippe Giral Pramod Anugu Quenna Wong Rainer Malik Rainer Rauramaa Ralph Burkhardt Rebecca Hardy Reinhold Schmidt Renée de Mutsert Richard W. Morris Rona J. Strawbridge S. Goya Wannamethee Sara Hägg Sonia Shah Stela McLachlan Stella Trompet Sudha Seshadri Sudhir Kurl Susan R. Heckbert Susan Ring Tamara B. Harris Terho Lehtimäki Tessel E. Galesloot Tina Shah Ulf de Faire Vincent Plagnol Wayne D. Rosamond Wendy Post Xiaofeng Zhu Xiaoling Zhang Xiuqing Guo Yasaman Saba MEGASTROKE Consortium Abbas Dehghan Adrie Seldenrijk Alanna C. Morrison Anders Hamsten Bruce M. Psaty Cornelia M. van Duijn Deborah A. Lawlor Dennis O. Mook-Kanamori Donald W. Bowden Helena Schmidt James F. Wilson James G. Wilson Jerome I. Rotter Joanna M. Wardlaw John Deanfield Julian Halcox Leo-Pekka Lyytikäinen Markus Loeffler Michele K. Evans Stéphanie Debette Steve E. Humphries Uwe Völker Vilmundur Gudnason Aroon D. Hingorani Johan L. M. Björkegren Juan P. Casas Christopher J. O’Donnell
author_sort	Nora Franceschini
title	GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes
title_short	GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes
title_full	GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes
title_fullStr	GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes
title_full_unstemmed	GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes
title_sort	gwas and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/32fac89a43804269804a3e18ff002db4
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lauramraffield gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT lenorejlauner gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT lescamholdt gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT marcusdorr gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT martindichgans gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT matthewtraylor gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT matthiassitzer gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT meenakumari gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT mikakivimaki gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT mikeanalls gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT ollemelander gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT olliraitakari gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT oscarhfranco gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT oscarlruedaochoa gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT panosroussos gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT peterhwhincup gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT philippeamouyel gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT philippegiral gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT pramodanugu gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT quennawong gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT rainermalik gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT rainerrauramaa gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT ralphburkhardt gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT rebeccahardy gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT reinholdschmidt gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT reneedemutsert gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT richardwmorris gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT ronajstrawbridge gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT sgoyawannamethee gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT sarahagg gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT soniashah gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT stelamclachlan gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT stellatrompet gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT sudhaseshadri gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT sudhirkurl gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT susanrheckbert gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT susanring gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT tamarabharris gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT terholehtimaki gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT tesselegalesloot gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT tinashah gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT ulfdefaire gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT vincentplagnol gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT waynedrosamond gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT wendypost gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT xiaofengzhu gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT xiaolingzhang gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT xiuqingguo gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT yasamansaba gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT megastrokeconsortium gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT abbasdehghan gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT adrieseldenrijk gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT alannacmorrison gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT andershamsten gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT brucempsaty gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT corneliamvanduijn gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT deborahalawlor gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT dennisomookkanamori gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT donaldwbowden gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT helenaschmidt gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT jamesfwilson gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT jamesgwilson gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT jeromeirotter gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT joannamwardlaw gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT johndeanfield gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT julianhalcox gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT leopekkalyytikainen gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT markusloeffler gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT michelekevans gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT stephaniedebette gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT steveehumphries gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT uwevolker gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT vilmundurgudnason gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT aroondhingorani gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT johanlmbjorkegren gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT juanpcasas gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes AT christopherjodonnell gwasandcolocalizationanalysesimplicatecarotidintimamediathicknessandcarotidplaquelociincardiovascularoutcomes
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GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes

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