The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer

The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer

MicroRNA miR-500a-5p has been linked to oncogenesis but its role in colorectal cancer (CRC) is largely unknown. Here, the authors investigate the role of miR-500a-5p in CRC in vitro and in vivo models and find that miR-500a-5p acts as a tumour suppressor in CRC by targeting the p300/YY1/HDAC2 axis.

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Autores principales: Weimei Tang, Weijie Zhou, Li Xiang, Xiaosheng Wu, Pei Zhang, Jing Wang, Guangnan Liu, Wenjing Zhang, Ying Peng, Xiaoting Huang, Jianqun Cai, Yang Bai, Lan Bai, Wei Zhu, Hongxiang Gu, Jing Xiong, Chen Ye, Aimin Li, Side Liu, Jide Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/32fb40eb2fb94539af63c954f7d4b1f9
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spelling oai:doaj.org-article:32fb40eb2fb94539af63c954f7d4b1f92021-12-02T17:02:18ZThe p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer10.1038/s41467-018-08225-32041-1723https://doaj.org/article/32fb40eb2fb94539af63c954f7d4b1f92019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08225-3https://doaj.org/toc/2041-1723MicroRNA miR-500a-5p has been linked to oncogenesis but its role in colorectal cancer (CRC) is largely unknown. Here, the authors investigate the role of miR-500a-5p in CRC in vitro and in vivo models and find that miR-500a-5p acts as a tumour suppressor in CRC by targeting the p300/YY1/HDAC2 axis.Weimei TangWeijie ZhouLi XiangXiaosheng WuPei ZhangJing WangGuangnan LiuWenjing ZhangYing PengXiaoting HuangJianqun CaiYang BaiLan BaiWei ZhuHongxiang GuJing XiongChen YeAimin LiSide LiuJide WangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Weimei Tang
Weijie Zhou
Li Xiang
Xiaosheng Wu
Pei Zhang
Jing Wang
Guangnan Liu
Wenjing Zhang
Ying Peng
Xiaoting Huang
Jianqun Cai
Yang Bai
Lan Bai
Wei Zhu
Hongxiang Gu
Jing Xiong
Chen Ye
Aimin Li
Side Liu
Jide Wang
The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer
description MicroRNA miR-500a-5p has been linked to oncogenesis but its role in colorectal cancer (CRC) is largely unknown. Here, the authors investigate the role of miR-500a-5p in CRC in vitro and in vivo models and find that miR-500a-5p acts as a tumour suppressor in CRC by targeting the p300/YY1/HDAC2 axis.
format article
author Weimei Tang
Weijie Zhou
Li Xiang
Xiaosheng Wu
Pei Zhang
Jing Wang
Guangnan Liu
Wenjing Zhang
Ying Peng
Xiaoting Huang
Jianqun Cai
Yang Bai
Lan Bai
Wei Zhu
Hongxiang Gu
Jing Xiong
Chen Ye
Aimin Li
Side Liu
Jide Wang
author_facet Weimei Tang
Weijie Zhou
Li Xiang
Xiaosheng Wu
Pei Zhang
Jing Wang
Guangnan Liu
Wenjing Zhang
Ying Peng
Xiaoting Huang
Jianqun Cai
Yang Bai
Lan Bai
Wei Zhu
Hongxiang Gu
Jing Xiong
Chen Ye
Aimin Li
Side Liu
Jide Wang
author_sort Weimei Tang
title The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer
title_short The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer
title_full The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer
title_fullStr The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer
title_full_unstemmed The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer
title_sort p300/yy1/mir-500a-5p/hdac2 signalling axis regulates cell proliferation in human colorectal cancer
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/32fb40eb2fb94539af63c954f7d4b1f9
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