A tissue-specific self-interacting chromatin domain forms independently of enhancer-promoter interactions

Self-interacting chromatin domains encompass genes and their cis-regulatory elements. Here the authors use high-resolution chromosome conformation capture and super-resolution imaging to study a 70 kb domain that includes the mouse α-globin regulatory locus and find that a tissue-specific self-inter...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jill M. Brown, Nigel A. Roberts, Bryony Graham, Dominic Waithe, Christoffer Lagerholm, Jelena M. Telenius, Sara De Ornellas, A. Marieke Oudelaar, Caroline Scott, Izabela Szczerbal, Christian Babbs, Mira T. Kassouf, Jim R. Hughes, Douglas R. Higgs, Veronica J. Buckle
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/330016a401574168bf45d1576eed899f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:330016a401574168bf45d1576eed899f
record_format	dspace
spelling	oai:doaj.org-article:330016a401574168bf45d1576eed899f2021-12-02T17:31:30ZA tissue-specific self-interacting chromatin domain forms independently of enhancer-promoter interactions10.1038/s41467-018-06248-42041-1723https://doaj.org/article/330016a401574168bf45d1576eed899f2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06248-4https://doaj.org/toc/2041-1723Self-interacting chromatin domains encompass genes and their cis-regulatory elements. Here the authors use high-resolution chromosome conformation capture and super-resolution imaging to study a 70 kb domain that includes the mouse α-globin regulatory locus and find that a tissue-specific self-interacting chromatin domain forms independently of enhancer-promoter interactions.Jill M. BrownNigel A. RobertsBryony GrahamDominic WaitheChristoffer LagerholmJelena M. TeleniusSara De OrnellasA. Marieke OudelaarCaroline ScottIzabela SzczerbalChristian BabbsMira T. KassoufJim R. HughesDouglas R. HiggsVeronica J. BuckleNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jill M. Brown Nigel A. Roberts Bryony Graham Dominic Waithe Christoffer Lagerholm Jelena M. Telenius Sara De Ornellas A. Marieke Oudelaar Caroline Scott Izabela Szczerbal Christian Babbs Mira T. Kassouf Jim R. Hughes Douglas R. Higgs Veronica J. Buckle A tissue-specific self-interacting chromatin domain forms independently of enhancer-promoter interactions
description	Self-interacting chromatin domains encompass genes and their cis-regulatory elements. Here the authors use high-resolution chromosome conformation capture and super-resolution imaging to study a 70 kb domain that includes the mouse α-globin regulatory locus and find that a tissue-specific self-interacting chromatin domain forms independently of enhancer-promoter interactions.
format	article
author	Jill M. Brown Nigel A. Roberts Bryony Graham Dominic Waithe Christoffer Lagerholm Jelena M. Telenius Sara De Ornellas A. Marieke Oudelaar Caroline Scott Izabela Szczerbal Christian Babbs Mira T. Kassouf Jim R. Hughes Douglas R. Higgs Veronica J. Buckle
author_facet	Jill M. Brown Nigel A. Roberts Bryony Graham Dominic Waithe Christoffer Lagerholm Jelena M. Telenius Sara De Ornellas A. Marieke Oudelaar Caroline Scott Izabela Szczerbal Christian Babbs Mira T. Kassouf Jim R. Hughes Douglas R. Higgs Veronica J. Buckle
author_sort	Jill M. Brown
title	A tissue-specific self-interacting chromatin domain forms independently of enhancer-promoter interactions
title_short	A tissue-specific self-interacting chromatin domain forms independently of enhancer-promoter interactions
title_full	A tissue-specific self-interacting chromatin domain forms independently of enhancer-promoter interactions
title_fullStr	A tissue-specific self-interacting chromatin domain forms independently of enhancer-promoter interactions
title_full_unstemmed	A tissue-specific self-interacting chromatin domain forms independently of enhancer-promoter interactions
title_sort	tissue-specific self-interacting chromatin domain forms independently of enhancer-promoter interactions
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/330016a401574168bf45d1576eed899f
work_keys_str_mv	AT jillmbrown atissuespecificselfinteractingchromatindomainformsindependentlyofenhancerpromoterinteractions AT nigelaroberts atissuespecificselfinteractingchromatindomainformsindependentlyofenhancerpromoterinteractions AT bryonygraham atissuespecificselfinteractingchromatindomainformsindependentlyofenhancerpromoterinteractions AT dominicwaithe atissuespecificselfinteractingchromatindomainformsindependentlyofenhancerpromoterinteractions AT christofferlagerholm atissuespecificselfinteractingchromatindomainformsindependentlyofenhancerpromoterinteractions AT jelenamtelenius atissuespecificselfinteractingchromatindomainformsindependentlyofenhancerpromoterinteractions AT saradeornellas atissuespecificselfinteractingchromatindomainformsindependentlyofenhancerpromoterinteractions AT amariekeoudelaar atissuespecificselfinteractingchromatindomainformsindependentlyofenhancerpromoterinteractions AT carolinescott atissuespecificselfinteractingchromatindomainformsindependentlyofenhancerpromoterinteractions AT izabelaszczerbal atissuespecificselfinteractingchromatindomainformsindependentlyofenhancerpromoterinteractions AT christianbabbs atissuespecificselfinteractingchromatindomainformsindependentlyofenhancerpromoterinteractions AT miratkassouf atissuespecificselfinteractingchromatindomainformsindependentlyofenhancerpromoterinteractions AT jimrhughes atissuespecificselfinteractingchromatindomainformsindependentlyofenhancerpromoterinteractions AT douglasrhiggs atissuespecificselfinteractingchromatindomainformsindependentlyofenhancerpromoterinteractions AT veronicajbuckle atissuespecificselfinteractingchromatindomainformsindependentlyofenhancerpromoterinteractions AT jillmbrown tissuespecificselfinteractingchromatindomainformsindependentlyofenhancerpromoterinteractions AT nigelaroberts tissuespecificselfinteractingchromatindomainformsindependentlyofenhancerpromoterinteractions AT bryonygraham tissuespecificselfinteractingchromatindomainformsindependentlyofenhancerpromoterinteractions AT dominicwaithe tissuespecificselfinteractingchromatindomainformsindependentlyofenhancerpromoterinteractions AT christofferlagerholm tissuespecificselfinteractingchromatindomainformsindependentlyofenhancerpromoterinteractions AT jelenamtelenius tissuespecificselfinteractingchromatindomainformsindependentlyofenhancerpromoterinteractions AT saradeornellas tissuespecificselfinteractingchromatindomainformsindependentlyofenhancerpromoterinteractions AT amariekeoudelaar tissuespecificselfinteractingchromatindomainformsindependentlyofenhancerpromoterinteractions AT carolinescott tissuespecificselfinteractingchromatindomainformsindependentlyofenhancerpromoterinteractions AT izabelaszczerbal tissuespecificselfinteractingchromatindomainformsindependentlyofenhancerpromoterinteractions AT christianbabbs tissuespecificselfinteractingchromatindomainformsindependentlyofenhancerpromoterinteractions AT miratkassouf tissuespecificselfinteractingchromatindomainformsindependentlyofenhancerpromoterinteractions AT jimrhughes tissuespecificselfinteractingchromatindomainformsindependentlyofenhancerpromoterinteractions AT douglasrhiggs tissuespecificselfinteractingchromatindomainformsindependentlyofenhancerpromoterinteractions AT veronicajbuckle tissuespecificselfinteractingchromatindomainformsindependentlyofenhancerpromoterinteractions
_version_	1718380603963867136

A tissue-specific self-interacting chromatin domain forms independently of enhancer-promoter interactions

Ejemplares similares