Amplification of Aminoglycoside Resistance Gene <italic toggle="yes">aphA1</italic> in <named-content content-type="genus-species">Acinetobacter baumannii</named-content> Results in Tobramycin Therapy Failure

Amplification of Aminoglycoside Resistance Gene <italic toggle="yes">aphA1</italic> in <named-content content-type="genus-species">Acinetobacter baumannii</named-content> Results in Tobramycin Therapy Failure

ABSTRACT Gene amplification is believed to play an important role in antibiotic resistance but has been rarely documented in clinical settings because of its unstable nature. We report a rise in MICs from 0.5 to 16 μg/ml in successive Acinetobacter baumannii isolated over 4 days from a patient being...

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Autores principales: Patrick McGann, Patrice Courvalin, Erik Snesrud, Robert J. Clifford, Eun-Jeong Yoon, Fatma Onmus-Leone, Ana C. Ong, Yoon I. Kwak, Catherine Grillot-Courvalin, Emil Lesho, Paige E. Waterman
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2014
Materias:
Microbiology
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Acceso en línea:https://doaj.org/article/3305610506bd48c8a4a3f3e1e7bcbc32
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