Advancing theranostics with tumor-targeting peptides for precision otolaryngology

Worldwide, about 600,000 head and neck squamous cell carcinoma (HNSCC) are detected annually, many of which involve high risk human papilloma virus (HPV). Surgery is the primary and desired first treatment option. Following surgery, the existence of cancer cells at the surgical margin is strongly as...

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Autores principales:	Chadwick L. Wright, Quintin Pan, Michael V. Knopp, Michael F. Tweedle
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2016
Materias:	Otorhinolaryngology RF1-547 Surgery RD1-811
Acceso en línea:	https://doaj.org/article/33082bea6a85492fbfd2fa98ad88e7d8
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spelling	oai:doaj.org-article:33082bea6a85492fbfd2fa98ad88e7d82021-12-02T12:05:42ZAdvancing theranostics with tumor-targeting peptides for precision otolaryngology2095-881110.1016/j.wjorl.2016.05.006https://doaj.org/article/33082bea6a85492fbfd2fa98ad88e7d82016-06-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095881116300166https://doaj.org/toc/2095-8811Worldwide, about 600,000 head and neck squamous cell carcinoma (HNSCC) are detected annually, many of which involve high risk human papilloma virus (HPV). Surgery is the primary and desired first treatment option. Following surgery, the existence of cancer cells at the surgical margin is strongly associated with eventual recurrence of cancer and a poor outcome. Despite improved surgical methods (robotics, microsurgery, endoscopic/laparoscopic, and external imaging), surgeons rely only on their vision and touch to locate tumors during surgery. Diagnostic imaging systems like computed tomography (CT), magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT) and positron-emission tomography (PET) are too large, slow and costly to use efficiently during most surgeries and, ultrasound imaging, while fast and portable, is not cancer specific. This purpose of this article is to review the fundamental technologies that will radically advance Precision Otolaryngology practices to the benefit of patients with HNSCC. In particular, this article will address the potential for tumor-targeting peptides to enable more precise diagnostic imaging while simultaneously advancing new therapeutic paradigms for next generation image-guided surgery, tumor-specific chemotherapeutic delivery and tumor-selective targeted radiotherapy (i.e., theranostic). Keywords: Squamous cell carcinoma, Peptide, Optical surgical navigation, Diagnostic imaging, TheranosticChadwick L. WrightQuintin PanMichael V. KnoppMichael F. TweedleKeAi Communications Co., Ltd.articleOtorhinolaryngologyRF1-547SurgeryRD1-811ENWorld Journal of Otorhinolaryngology-Head and Neck Surgery, Vol 2, Iss 2, Pp 98-108 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Otorhinolaryngology RF1-547 Surgery RD1-811
spellingShingle	Otorhinolaryngology RF1-547 Surgery RD1-811 Chadwick L. Wright Quintin Pan Michael V. Knopp Michael F. Tweedle Advancing theranostics with tumor-targeting peptides for precision otolaryngology
description	Worldwide, about 600,000 head and neck squamous cell carcinoma (HNSCC) are detected annually, many of which involve high risk human papilloma virus (HPV). Surgery is the primary and desired first treatment option. Following surgery, the existence of cancer cells at the surgical margin is strongly associated with eventual recurrence of cancer and a poor outcome. Despite improved surgical methods (robotics, microsurgery, endoscopic/laparoscopic, and external imaging), surgeons rely only on their vision and touch to locate tumors during surgery. Diagnostic imaging systems like computed tomography (CT), magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT) and positron-emission tomography (PET) are too large, slow and costly to use efficiently during most surgeries and, ultrasound imaging, while fast and portable, is not cancer specific. This purpose of this article is to review the fundamental technologies that will radically advance Precision Otolaryngology practices to the benefit of patients with HNSCC. In particular, this article will address the potential for tumor-targeting peptides to enable more precise diagnostic imaging while simultaneously advancing new therapeutic paradigms for next generation image-guided surgery, tumor-specific chemotherapeutic delivery and tumor-selective targeted radiotherapy (i.e., theranostic). Keywords: Squamous cell carcinoma, Peptide, Optical surgical navigation, Diagnostic imaging, Theranostic
format	article
author	Chadwick L. Wright Quintin Pan Michael V. Knopp Michael F. Tweedle
author_facet	Chadwick L. Wright Quintin Pan Michael V. Knopp Michael F. Tweedle
author_sort	Chadwick L. Wright
title	Advancing theranostics with tumor-targeting peptides for precision otolaryngology
title_short	Advancing theranostics with tumor-targeting peptides for precision otolaryngology
title_full	Advancing theranostics with tumor-targeting peptides for precision otolaryngology
title_fullStr	Advancing theranostics with tumor-targeting peptides for precision otolaryngology
title_full_unstemmed	Advancing theranostics with tumor-targeting peptides for precision otolaryngology
title_sort	advancing theranostics with tumor-targeting peptides for precision otolaryngology
publisher	KeAi Communications Co., Ltd.
publishDate	2016
url	https://doaj.org/article/33082bea6a85492fbfd2fa98ad88e7d8
work_keys_str_mv	AT chadwicklwright advancingtheranosticswithtumortargetingpeptidesforprecisionotolaryngology AT quintinpan advancingtheranosticswithtumortargetingpeptidesforprecisionotolaryngology AT michaelvknopp advancingtheranosticswithtumortargetingpeptidesforprecisionotolaryngology AT michaelftweedle advancingtheranosticswithtumortargetingpeptidesforprecisionotolaryngology
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Advancing theranostics with tumor-targeting peptides for precision otolaryngology

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