Dynamic changes in arterial blood gas during cardiopulmonary resuscitation in out-of-hospital cardiac arrest

Abstract We aimed to investigate the prognostic value of dynamic changes in arterial blood gas analysis (ABGA) measured after the start of cardiopulmonary resuscitation (CPR) for return of spontaneous circulation (ROSC) in patients with out-of-hospital cardiac arrest (OHCA). This prospective observa...

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Autores principales:	Seok-In Hong, June-Sung Kim, Youn-Jung Kim, Won Young Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/33093bde484546688694f58298715d4f
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spelling	oai:doaj.org-article:33093bde484546688694f58298715d4f2021-12-05T12:11:36ZDynamic changes in arterial blood gas during cardiopulmonary resuscitation in out-of-hospital cardiac arrest10.1038/s41598-021-02764-42045-2322https://doaj.org/article/33093bde484546688694f58298715d4f2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02764-4https://doaj.org/toc/2045-2322Abstract We aimed to investigate the prognostic value of dynamic changes in arterial blood gas analysis (ABGA) measured after the start of cardiopulmonary resuscitation (CPR) for return of spontaneous circulation (ROSC) in patients with out-of-hospital cardiac arrest (OHCA). This prospective observational study was conducted at the emergency department of a university hospital from February 2018 to February 2020. All blood samples for gas analysis were collected from a radial or femoral arterial line, which was inserted during CPR. Changes in ABGA parameters were expressed as delta (Δ), defined as the values of the second ABGA minus the values of the initial ABGA. The primary outcome was sustained ROSC. Out of the 80 patients included in the analysis, 13 achieved sustained ROSC after in-hospital resuscitation. Multivariable logistic analysis revealed that ΔpaO2 (odds ratio [OR] = 1.023; 95% confidence interval [CI] = 1.004–1.043, p = 0.020) along with prehospital shockable rhythm (OR = 84.680; 95% CI = 2.561–2799.939, p = 0.013) and total resuscitation duration (OR = 0.881; 95% CI = 0.805–0.964, p = 0.006) were significant predictors for sustained ROSC. Our study suggests a possible association between ΔpaO2 in ABGA during CPR and an increased rate of sustained ROSC in the late phase of OHCA.Seok-In HongJune-Sung KimYoun-Jung KimWon Young KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Seok-In Hong June-Sung Kim Youn-Jung Kim Won Young Kim Dynamic changes in arterial blood gas during cardiopulmonary resuscitation in out-of-hospital cardiac arrest
description	Abstract We aimed to investigate the prognostic value of dynamic changes in arterial blood gas analysis (ABGA) measured after the start of cardiopulmonary resuscitation (CPR) for return of spontaneous circulation (ROSC) in patients with out-of-hospital cardiac arrest (OHCA). This prospective observational study was conducted at the emergency department of a university hospital from February 2018 to February 2020. All blood samples for gas analysis were collected from a radial or femoral arterial line, which was inserted during CPR. Changes in ABGA parameters were expressed as delta (Δ), defined as the values of the second ABGA minus the values of the initial ABGA. The primary outcome was sustained ROSC. Out of the 80 patients included in the analysis, 13 achieved sustained ROSC after in-hospital resuscitation. Multivariable logistic analysis revealed that ΔpaO2 (odds ratio [OR] = 1.023; 95% confidence interval [CI] = 1.004–1.043, p = 0.020) along with prehospital shockable rhythm (OR = 84.680; 95% CI = 2.561–2799.939, p = 0.013) and total resuscitation duration (OR = 0.881; 95% CI = 0.805–0.964, p = 0.006) were significant predictors for sustained ROSC. Our study suggests a possible association between ΔpaO2 in ABGA during CPR and an increased rate of sustained ROSC in the late phase of OHCA.
format	article
author	Seok-In Hong June-Sung Kim Youn-Jung Kim Won Young Kim
author_facet	Seok-In Hong June-Sung Kim Youn-Jung Kim Won Young Kim
author_sort	Seok-In Hong
title	Dynamic changes in arterial blood gas during cardiopulmonary resuscitation in out-of-hospital cardiac arrest
title_short	Dynamic changes in arterial blood gas during cardiopulmonary resuscitation in out-of-hospital cardiac arrest
title_full	Dynamic changes in arterial blood gas during cardiopulmonary resuscitation in out-of-hospital cardiac arrest
title_fullStr	Dynamic changes in arterial blood gas during cardiopulmonary resuscitation in out-of-hospital cardiac arrest
title_full_unstemmed	Dynamic changes in arterial blood gas during cardiopulmonary resuscitation in out-of-hospital cardiac arrest
title_sort	dynamic changes in arterial blood gas during cardiopulmonary resuscitation in out-of-hospital cardiac arrest
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/33093bde484546688694f58298715d4f
work_keys_str_mv	AT seokinhong dynamicchangesinarterialbloodgasduringcardiopulmonaryresuscitationinoutofhospitalcardiacarrest AT junesungkim dynamicchangesinarterialbloodgasduringcardiopulmonaryresuscitationinoutofhospitalcardiacarrest AT younjungkim dynamicchangesinarterialbloodgasduringcardiopulmonaryresuscitationinoutofhospitalcardiacarrest AT wonyoungkim dynamicchangesinarterialbloodgasduringcardiopulmonaryresuscitationinoutofhospitalcardiacarrest
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Dynamic changes in arterial blood gas during cardiopulmonary resuscitation in out-of-hospital cardiac arrest

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