Transcription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tracts

Indels that are commonly found in cancer genomes are characterized by non-random sequence composition and localisation. Here, the authors described a method to investigate transcriptional strand asymmetries and sequence-context specific mechanisms that alter the likelihood of insertions and deletion...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ilias Georgakopoulos-Soares, Gene Koh, Sophie E. Momen, Josef Jiricny, Martin Hemberg, Serena Nik-Zainal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/330a18a3bad7426cba3f743bc68365db
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:330a18a3bad7426cba3f743bc68365db
record_format	dspace
spelling	oai:doaj.org-article:330a18a3bad7426cba3f743bc68365db2021-12-02T15:39:17ZTranscription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tracts10.1038/s41467-020-15901-w2041-1723https://doaj.org/article/330a18a3bad7426cba3f743bc68365db2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15901-whttps://doaj.org/toc/2041-1723Indels that are commonly found in cancer genomes are characterized by non-random sequence composition and localisation. Here, the authors described a method to investigate transcriptional strand asymmetries and sequence-context specific mechanisms that alter the likelihood of insertions and deletions.Ilias Georgakopoulos-SoaresGene KohSophie E. MomenJosef JiricnyMartin HembergSerena Nik-ZainalNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ilias Georgakopoulos-Soares Gene Koh Sophie E. Momen Josef Jiricny Martin Hemberg Serena Nik-Zainal Transcription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tracts
description	Indels that are commonly found in cancer genomes are characterized by non-random sequence composition and localisation. Here, the authors described a method to investigate transcriptional strand asymmetries and sequence-context specific mechanisms that alter the likelihood of insertions and deletions.
format	article
author	Ilias Georgakopoulos-Soares Gene Koh Sophie E. Momen Josef Jiricny Martin Hemberg Serena Nik-Zainal
author_facet	Ilias Georgakopoulos-Soares Gene Koh Sophie E. Momen Josef Jiricny Martin Hemberg Serena Nik-Zainal
author_sort	Ilias Georgakopoulos-Soares
title	Transcription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tracts
title_short	Transcription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tracts
title_full	Transcription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tracts
title_fullStr	Transcription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tracts
title_full_unstemmed	Transcription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tracts
title_sort	transcription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tracts
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/330a18a3bad7426cba3f743bc68365db
work_keys_str_mv	AT iliasgeorgakopoulossoares transcriptioncoupledrepairandmismatchrepaircontributetowardspreservinggenomeintegrityatmononucleotiderepeattracts AT genekoh transcriptioncoupledrepairandmismatchrepaircontributetowardspreservinggenomeintegrityatmononucleotiderepeattracts AT sophieemomen transcriptioncoupledrepairandmismatchrepaircontributetowardspreservinggenomeintegrityatmononucleotiderepeattracts AT josefjiricny transcriptioncoupledrepairandmismatchrepaircontributetowardspreservinggenomeintegrityatmononucleotiderepeattracts AT martinhemberg transcriptioncoupledrepairandmismatchrepaircontributetowardspreservinggenomeintegrityatmononucleotiderepeattracts AT serenanikzainal transcriptioncoupledrepairandmismatchrepaircontributetowardspreservinggenomeintegrityatmononucleotiderepeattracts
_version_	1718385924947050496

Transcription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tracts

Ejemplares similares