Ash1l and lnc-Smad3 coordinate Smad3 locus accessibility to modulate iTreg polarization and T cell autoimmunity

Ash1l and lnc-Smad3 coordinate Smad3 locus accessibility to modulate iTreg polarization and T cell autoimmunity

The transcriptional program activated by Smad2/Smad3 is critical for the induction and function of regulatory T cells. Here the authors show that the expression of Smad3 is modulated by the complementary functions of a methyltransferase Ash1l and an lncRNA lnc-Smad3 on the promoter accessibility of...

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Autores principales: Meng Xia, Juan Liu, Shuxun Liu, Kun Chen, Hongyu Lin, Minghong Jiang, Xiaoqing Xu, Yiquan Xue, Wei Liu, Yan Gu, Xiang Zhang, Zhiqing Li, Lin Yi, Youcun Qian, Chen Zhou, Ru Li, Xuan Zhang, Zhanguo Li, Xuetao Cao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/330b9b0908f84e2aabfc8b87a44e5027
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spelling oai:doaj.org-article:330b9b0908f84e2aabfc8b87a44e50272021-12-02T14:42:04ZAsh1l and lnc-Smad3 coordinate Smad3 locus accessibility to modulate iTreg polarization and T cell autoimmunity10.1038/ncomms158182041-1723https://doaj.org/article/330b9b0908f84e2aabfc8b87a44e50272017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15818https://doaj.org/toc/2041-1723The transcriptional program activated by Smad2/Smad3 is critical for the induction and function of regulatory T cells. Here the authors show that the expression of Smad3 is modulated by the complementary functions of a methyltransferase Ash1l and an lncRNA lnc-Smad3 on the promoter accessibility of the mouseSmad3locus.Meng XiaJuan LiuShuxun LiuKun ChenHongyu LinMinghong JiangXiaoqing XuYiquan XueWei LiuYan GuXiang ZhangZhiqing LiLin YiYoucun QianChen ZhouRu LiXuan ZhangZhanguo LiXuetao CaoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Meng Xia
Juan Liu
Shuxun Liu
Kun Chen
Hongyu Lin
Minghong Jiang
Xiaoqing Xu
Yiquan Xue
Wei Liu
Yan Gu
Xiang Zhang
Zhiqing Li
Lin Yi
Youcun Qian
Chen Zhou
Ru Li
Xuan Zhang
Zhanguo Li
Xuetao Cao
Ash1l and lnc-Smad3 coordinate Smad3 locus accessibility to modulate iTreg polarization and T cell autoimmunity
description The transcriptional program activated by Smad2/Smad3 is critical for the induction and function of regulatory T cells. Here the authors show that the expression of Smad3 is modulated by the complementary functions of a methyltransferase Ash1l and an lncRNA lnc-Smad3 on the promoter accessibility of the mouseSmad3locus.
format article
author Meng Xia
Juan Liu
Shuxun Liu
Kun Chen
Hongyu Lin
Minghong Jiang
Xiaoqing Xu
Yiquan Xue
Wei Liu
Yan Gu
Xiang Zhang
Zhiqing Li
Lin Yi
Youcun Qian
Chen Zhou
Ru Li
Xuan Zhang
Zhanguo Li
Xuetao Cao
author_facet Meng Xia
Juan Liu
Shuxun Liu
Kun Chen
Hongyu Lin
Minghong Jiang
Xiaoqing Xu
Yiquan Xue
Wei Liu
Yan Gu
Xiang Zhang
Zhiqing Li
Lin Yi
Youcun Qian
Chen Zhou
Ru Li
Xuan Zhang
Zhanguo Li
Xuetao Cao
author_sort Meng Xia
title Ash1l and lnc-Smad3 coordinate Smad3 locus accessibility to modulate iTreg polarization and T cell autoimmunity
title_short Ash1l and lnc-Smad3 coordinate Smad3 locus accessibility to modulate iTreg polarization and T cell autoimmunity
title_full Ash1l and lnc-Smad3 coordinate Smad3 locus accessibility to modulate iTreg polarization and T cell autoimmunity
title_fullStr Ash1l and lnc-Smad3 coordinate Smad3 locus accessibility to modulate iTreg polarization and T cell autoimmunity
title_full_unstemmed Ash1l and lnc-Smad3 coordinate Smad3 locus accessibility to modulate iTreg polarization and T cell autoimmunity
title_sort ash1l and lnc-smad3 coordinate smad3 locus accessibility to modulate itreg polarization and t cell autoimmunity
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/330b9b0908f84e2aabfc8b87a44e5027
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