Characterizing the Qatar advanced-phase SARS-CoV-2 epidemic

Abstract The overarching objective of this study was to provide the descriptive epidemiology of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic in Qatar by addressing specific research questions through a series of national epidemiologic studies. Sources of data were the ce...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Laith J. Abu-Raddad, Hiam Chemaitelly, Houssein H. Ayoub, Zaina Al Kanaani, Abdullatif Al Khal, Einas Al Kuwari, Adeel A. Butt, Peter Coyle, Andrew Jeremijenko, Anvar Hassan Kaleeckal, Ali Nizar Latif, Robert C. Owen, Hanan F. Abdul Rahim, Samya A. Al Abdulla, Mohamed G. Al Kuwari, Mujeeb C. Kandy, Hatoun Saeb, Shazia Nadeem N. Ahmed, Hamad Eid Al Romaihi, Devendra Bansal, Louise Dalton, Mohamed H. Al-Thani, Roberto Bertollini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/330d87f1ea0e449491cee18fd5726bdb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:330d87f1ea0e449491cee18fd5726bdb
record_format	dspace
spelling	oai:doaj.org-article:330d87f1ea0e449491cee18fd5726bdb2021-12-02T16:30:57ZCharacterizing the Qatar advanced-phase SARS-CoV-2 epidemic10.1038/s41598-021-85428-72045-2322https://doaj.org/article/330d87f1ea0e449491cee18fd5726bdb2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85428-7https://doaj.org/toc/2045-2322Abstract The overarching objective of this study was to provide the descriptive epidemiology of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic in Qatar by addressing specific research questions through a series of national epidemiologic studies. Sources of data were the centralized and standardized national databases for SARS-CoV-2 infection. By July 10, 2020, 397,577 individuals had been tested for SARS-CoV-2 using polymerase-chain-reaction (PCR), of whom 110,986 were positive, a positivity cumulative rate of 27.9% (95% CI 27.8–28.1%). As of July 5, case severity rate, based on World Health Organization (WHO) severity classification, was 3.4% and case fatality rate was 1.4 per 1,000 persons. Age was by far the strongest predictor of severe, critical, or fatal infection. PCR positivity of nasopharyngeal/oropharyngeal swabs in a national community survey (May 6–7) including 1,307 participants was 14.9% (95% CI 11.5–19.0%); 58.5% of those testing positive were asymptomatic. Across 448 ad-hoc testing campaigns in workplaces and residential areas including 26,715 individuals, pooled mean PCR positivity was 15.6% (95% CI 13.7–17.7%). SARS-CoV-2 antibody prevalence was 24.0% (95% CI 23.3–24.6%) in 32,970 residual clinical blood specimens. Antibody prevalence was only 47.3% (95% CI 46.2–48.5%) in those who had at least one PCR positive result, but 91.3% (95% CI 89.5–92.9%) among those who were PCR positive > 3 weeks before serology testing. Qatar has experienced a large SARS-CoV-2 epidemic that is rapidly declining, apparently due to growing immunity levels in the population.Laith J. Abu-RaddadHiam ChemaitellyHoussein H. AyoubZaina Al KanaaniAbdullatif Al KhalEinas Al KuwariAdeel A. ButtPeter CoyleAndrew JeremijenkoAnvar Hassan KaleeckalAli Nizar LatifRobert C. OwenHanan F. Abdul RahimSamya A. Al AbdullaMohamed G. Al KuwariMujeeb C. KandyHatoun SaebShazia Nadeem N. AhmedHamad Eid Al RomaihiDevendra BansalLouise DaltonMohamed H. Al-ThaniRoberto BertolliniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Laith J. Abu-Raddad Hiam Chemaitelly Houssein H. Ayoub Zaina Al Kanaani Abdullatif Al Khal Einas Al Kuwari Adeel A. Butt Peter Coyle Andrew Jeremijenko Anvar Hassan Kaleeckal Ali Nizar Latif Robert C. Owen Hanan F. Abdul Rahim Samya A. Al Abdulla Mohamed G. Al Kuwari Mujeeb C. Kandy Hatoun Saeb Shazia Nadeem N. Ahmed Hamad Eid Al Romaihi Devendra Bansal Louise Dalton Mohamed H. Al-Thani Roberto Bertollini Characterizing the Qatar advanced-phase SARS-CoV-2 epidemic
description	Abstract The overarching objective of this study was to provide the descriptive epidemiology of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic in Qatar by addressing specific research questions through a series of national epidemiologic studies. Sources of data were the centralized and standardized national databases for SARS-CoV-2 infection. By July 10, 2020, 397,577 individuals had been tested for SARS-CoV-2 using polymerase-chain-reaction (PCR), of whom 110,986 were positive, a positivity cumulative rate of 27.9% (95% CI 27.8–28.1%). As of July 5, case severity rate, based on World Health Organization (WHO) severity classification, was 3.4% and case fatality rate was 1.4 per 1,000 persons. Age was by far the strongest predictor of severe, critical, or fatal infection. PCR positivity of nasopharyngeal/oropharyngeal swabs in a national community survey (May 6–7) including 1,307 participants was 14.9% (95% CI 11.5–19.0%); 58.5% of those testing positive were asymptomatic. Across 448 ad-hoc testing campaigns in workplaces and residential areas including 26,715 individuals, pooled mean PCR positivity was 15.6% (95% CI 13.7–17.7%). SARS-CoV-2 antibody prevalence was 24.0% (95% CI 23.3–24.6%) in 32,970 residual clinical blood specimens. Antibody prevalence was only 47.3% (95% CI 46.2–48.5%) in those who had at least one PCR positive result, but 91.3% (95% CI 89.5–92.9%) among those who were PCR positive > 3 weeks before serology testing. Qatar has experienced a large SARS-CoV-2 epidemic that is rapidly declining, apparently due to growing immunity levels in the population.
format	article
author	Laith J. Abu-Raddad Hiam Chemaitelly Houssein H. Ayoub Zaina Al Kanaani Abdullatif Al Khal Einas Al Kuwari Adeel A. Butt Peter Coyle Andrew Jeremijenko Anvar Hassan Kaleeckal Ali Nizar Latif Robert C. Owen Hanan F. Abdul Rahim Samya A. Al Abdulla Mohamed G. Al Kuwari Mujeeb C. Kandy Hatoun Saeb Shazia Nadeem N. Ahmed Hamad Eid Al Romaihi Devendra Bansal Louise Dalton Mohamed H. Al-Thani Roberto Bertollini
author_facet	Laith J. Abu-Raddad Hiam Chemaitelly Houssein H. Ayoub Zaina Al Kanaani Abdullatif Al Khal Einas Al Kuwari Adeel A. Butt Peter Coyle Andrew Jeremijenko Anvar Hassan Kaleeckal Ali Nizar Latif Robert C. Owen Hanan F. Abdul Rahim Samya A. Al Abdulla Mohamed G. Al Kuwari Mujeeb C. Kandy Hatoun Saeb Shazia Nadeem N. Ahmed Hamad Eid Al Romaihi Devendra Bansal Louise Dalton Mohamed H. Al-Thani Roberto Bertollini
author_sort	Laith J. Abu-Raddad
title	Characterizing the Qatar advanced-phase SARS-CoV-2 epidemic
title_short	Characterizing the Qatar advanced-phase SARS-CoV-2 epidemic
title_full	Characterizing the Qatar advanced-phase SARS-CoV-2 epidemic
title_fullStr	Characterizing the Qatar advanced-phase SARS-CoV-2 epidemic
title_full_unstemmed	Characterizing the Qatar advanced-phase SARS-CoV-2 epidemic
title_sort	characterizing the qatar advanced-phase sars-cov-2 epidemic
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/330d87f1ea0e449491cee18fd5726bdb
work_keys_str_mv	AT laithjaburaddad characterizingtheqataradvancedphasesarscov2epidemic AT hiamchemaitelly characterizingtheqataradvancedphasesarscov2epidemic AT housseinhayoub characterizingtheqataradvancedphasesarscov2epidemic AT zainaalkanaani characterizingtheqataradvancedphasesarscov2epidemic AT abdullatifalkhal characterizingtheqataradvancedphasesarscov2epidemic AT einasalkuwari characterizingtheqataradvancedphasesarscov2epidemic AT adeelabutt characterizingtheqataradvancedphasesarscov2epidemic AT petercoyle characterizingtheqataradvancedphasesarscov2epidemic AT andrewjeremijenko characterizingtheqataradvancedphasesarscov2epidemic AT anvarhassankaleeckal characterizingtheqataradvancedphasesarscov2epidemic AT alinizarlatif characterizingtheqataradvancedphasesarscov2epidemic AT robertcowen characterizingtheqataradvancedphasesarscov2epidemic AT hananfabdulrahim characterizingtheqataradvancedphasesarscov2epidemic AT samyaaalabdulla characterizingtheqataradvancedphasesarscov2epidemic AT mohamedgalkuwari characterizingtheqataradvancedphasesarscov2epidemic AT mujeebckandy characterizingtheqataradvancedphasesarscov2epidemic AT hatounsaeb characterizingtheqataradvancedphasesarscov2epidemic AT shazianadeemnahmed characterizingtheqataradvancedphasesarscov2epidemic AT hamadeidalromaihi characterizingtheqataradvancedphasesarscov2epidemic AT devendrabansal characterizingtheqataradvancedphasesarscov2epidemic AT louisedalton characterizingtheqataradvancedphasesarscov2epidemic AT mohamedhalthani characterizingtheqataradvancedphasesarscov2epidemic AT robertobertollini characterizingtheqataradvancedphasesarscov2epidemic
_version_	1718383862553247744

Characterizing the Qatar advanced-phase SARS-CoV-2 epidemic

Ejemplares similares