Relationship of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratio With Visual Acuity After Surgical Repair of Open Globe Injury

Purpose: To assess the relationship and prognostic value of the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) with poor final best-corrected visual acuity (BCVA) after surgical repair of open globe injuries (OGI) in adults.Design: Retrospective analysis of data from an...

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Autores principales:	Karim Mohamed-Noriega, Alan B. Treviño-Herrera, Jibran Mohamed-Noriega, Braulio H. Velasco-Sepúlveda, Víctor A. Martínez-Pacheco, Dante A. Guevara-Villarreal, Delia L. Rodríguez-Medellín, Anna G. Sepúlveda-Salinas, Gerardo Villarreal-Méndez, Jesús H. González-Cortés, Rodrigo E. Elizondo-Omaña, Santos Guzmán-López, Jesús Mohamed-Hamsho
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	prognostic platelet lymphocyte ratio (PLR) neutrophil lymphocyte ratio (NLR) severe visual impairment ocular injury ocular trauma Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3313cbbacaa34fc8a74445605515bee6
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spelling	oai:doaj.org-article:3313cbbacaa34fc8a74445605515bee62021-11-22T05:15:25ZRelationship of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratio With Visual Acuity After Surgical Repair of Open Globe Injury2296-858X10.3389/fmed.2021.697585https://doaj.org/article/3313cbbacaa34fc8a74445605515bee62021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.697585/fullhttps://doaj.org/toc/2296-858XPurpose: To assess the relationship and prognostic value of the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) with poor final best-corrected visual acuity (BCVA) after surgical repair of open globe injuries (OGI) in adults.Design: Retrospective analysis of data from an ongoing prospective cohort of consecutive patients.Methods: In a tertiary university hospital, 197 eyes of 197 patients were included between 2013 and 2017. NLR and PLR were obtained from pre-operative blood tests to analyze its relationship with poor final BCVA.Results: Severe visual impairment (SVI) was defined as ≤20/200, and was observed in 96 (48.7%) patients after surgical repair of OGI. SVI patients had higher NLR (7.4 ± 6.6 vs. 4.0 ± 3.2, p < 0.001), and PLR (167 ± 92 vs. 139 ± 64; p = 0.021) than non-SVI. NLR ≥ 3.47 and PLR ≥ 112.2 were the best cut-off values for SVI, were univariate risk factors for SVI, and had sensitivity: 69.0, 71.4, and specificity: 63.6, 44.8, respectively. In multivariate analysis, only OTS, athalamia, and hyphema remained as risk factors. NLR had significant correlation with ocular trauma score (OTS) (r = −0.389, p < 0.001) and final BCVA (r = 0.345, p < 0.001).Limitations: Simultaneous trauma in other parts of the body that could influence the laboratory findings.Conclusion: Patients with SVI after a repaired OGI had increased pre-operative NLR and PLR levels. High NLR and PLR are risk factors for SVI in univariate analysis. It is confirmed that low OTS is a risk factor for SVI. High NLR and PLR could be used as a prognostic tool to identify patients at higher risk for SVI after repair of OGI.Karim Mohamed-NoriegaAlan B. Treviño-HerreraJibran Mohamed-NoriegaBraulio H. Velasco-SepúlvedaVíctor A. Martínez-PachecoDante A. Guevara-VillarrealDelia L. Rodríguez-MedellínAnna G. Sepúlveda-SalinasGerardo Villarreal-MéndezJesús H. González-CortésRodrigo E. Elizondo-OmañaSantos Guzmán-LópezJesús Mohamed-HamshoFrontiers Media S.A.articleprognosticplatelet lymphocyte ratio (PLR)neutrophil lymphocyte ratio (NLR)severe visual impairmentocular injuryocular traumaMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	prognostic platelet lymphocyte ratio (PLR) neutrophil lymphocyte ratio (NLR) severe visual impairment ocular injury ocular trauma Medicine (General) R5-920
spellingShingle	prognostic platelet lymphocyte ratio (PLR) neutrophil lymphocyte ratio (NLR) severe visual impairment ocular injury ocular trauma Medicine (General) R5-920 Karim Mohamed-Noriega Alan B. Treviño-Herrera Jibran Mohamed-Noriega Braulio H. Velasco-Sepúlveda Víctor A. Martínez-Pacheco Dante A. Guevara-Villarreal Delia L. Rodríguez-Medellín Anna G. Sepúlveda-Salinas Gerardo Villarreal-Méndez Jesús H. González-Cortés Rodrigo E. Elizondo-Omaña Santos Guzmán-López Jesús Mohamed-Hamsho Relationship of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratio With Visual Acuity After Surgical Repair of Open Globe Injury
description	Purpose: To assess the relationship and prognostic value of the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) with poor final best-corrected visual acuity (BCVA) after surgical repair of open globe injuries (OGI) in adults.Design: Retrospective analysis of data from an ongoing prospective cohort of consecutive patients.Methods: In a tertiary university hospital, 197 eyes of 197 patients were included between 2013 and 2017. NLR and PLR were obtained from pre-operative blood tests to analyze its relationship with poor final BCVA.Results: Severe visual impairment (SVI) was defined as ≤20/200, and was observed in 96 (48.7%) patients after surgical repair of OGI. SVI patients had higher NLR (7.4 ± 6.6 vs. 4.0 ± 3.2, p < 0.001), and PLR (167 ± 92 vs. 139 ± 64; p = 0.021) than non-SVI. NLR ≥ 3.47 and PLR ≥ 112.2 were the best cut-off values for SVI, were univariate risk factors for SVI, and had sensitivity: 69.0, 71.4, and specificity: 63.6, 44.8, respectively. In multivariate analysis, only OTS, athalamia, and hyphema remained as risk factors. NLR had significant correlation with ocular trauma score (OTS) (r = −0.389, p < 0.001) and final BCVA (r = 0.345, p < 0.001).Limitations: Simultaneous trauma in other parts of the body that could influence the laboratory findings.Conclusion: Patients with SVI after a repaired OGI had increased pre-operative NLR and PLR levels. High NLR and PLR are risk factors for SVI in univariate analysis. It is confirmed that low OTS is a risk factor for SVI. High NLR and PLR could be used as a prognostic tool to identify patients at higher risk for SVI after repair of OGI.
format	article
author	Karim Mohamed-Noriega Alan B. Treviño-Herrera Jibran Mohamed-Noriega Braulio H. Velasco-Sepúlveda Víctor A. Martínez-Pacheco Dante A. Guevara-Villarreal Delia L. Rodríguez-Medellín Anna G. Sepúlveda-Salinas Gerardo Villarreal-Méndez Jesús H. González-Cortés Rodrigo E. Elizondo-Omaña Santos Guzmán-López Jesús Mohamed-Hamsho
author_facet	Karim Mohamed-Noriega Alan B. Treviño-Herrera Jibran Mohamed-Noriega Braulio H. Velasco-Sepúlveda Víctor A. Martínez-Pacheco Dante A. Guevara-Villarreal Delia L. Rodríguez-Medellín Anna G. Sepúlveda-Salinas Gerardo Villarreal-Méndez Jesús H. González-Cortés Rodrigo E. Elizondo-Omaña Santos Guzmán-López Jesús Mohamed-Hamsho
author_sort	Karim Mohamed-Noriega
title	Relationship of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratio With Visual Acuity After Surgical Repair of Open Globe Injury
title_short	Relationship of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratio With Visual Acuity After Surgical Repair of Open Globe Injury
title_full	Relationship of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratio With Visual Acuity After Surgical Repair of Open Globe Injury
title_fullStr	Relationship of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratio With Visual Acuity After Surgical Repair of Open Globe Injury
title_full_unstemmed	Relationship of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratio With Visual Acuity After Surgical Repair of Open Globe Injury
title_sort	relationship of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio with visual acuity after surgical repair of open globe injury
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/3313cbbacaa34fc8a74445605515bee6
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Relationship of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratio With Visual Acuity After Surgical Repair of Open Globe Injury

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