Assessment of the Effect of Vitiligo on Subfoveal Choroidal Thickness Using Spectral-Domain Optical Coherence Tomography

Yousef Ahmed Fouad,1 Abdelrahman Gaber Salman,1 Thanaa Helmy Mohamed,1 Randa Hesham Ali Abdelgawad,1 Samah Ibraheem Hassen2 1Department of Ophthalmology, Faculty of Medicine, Ain Shams University, Cairo, Egypt; 2Department of Dermatology, Faculty of Medicine, Ain Shams University, Cairo, EgyptCorres...

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Autores principales:	Fouad YA, Salman AG, Mohamed TH, Abdelgawad RHA, Hassen SI
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	vitiligo oct optical coherence tomography choroidal thickness Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/33151728cea94584b7789382518eb370
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spelling	oai:doaj.org-article:33151728cea94584b7789382518eb3702021-12-02T12:28:02ZAssessment of the Effect of Vitiligo on Subfoveal Choroidal Thickness Using Spectral-Domain Optical Coherence Tomography1177-5483https://doaj.org/article/33151728cea94584b7789382518eb3702020-08-01T00:00:00Zhttps://www.dovepress.com/assessment-of-the-effect-of-vitiligo-on-subfoveal-choroidal-thickness--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Yousef Ahmed Fouad,1 Abdelrahman Gaber Salman,1 Thanaa Helmy Mohamed,1 Randa Hesham Ali Abdelgawad,1 Samah Ibraheem Hassen2 1Department of Ophthalmology, Faculty of Medicine, Ain Shams University, Cairo, Egypt; 2Department of Dermatology, Faculty of Medicine, Ain Shams University, Cairo, EgyptCorrespondence: Yousef Ahmed FouadDepartment of Ophthalmology, Faculty of Medicine, Ain Shams University, Ramses Street, Cairo, EgyptTel +20 1063781237Email yousef.a.fouad@gmail.comBackground: Vitiligo is a common skin condition affecting 0.5– 2% of the population. The exact etiology of the condition is unknown, but the result is autoimmune destruction of melanocytes. The eye is rich in melanocytes, especially in the retinal pigment epithelium and choroid. Little is known about the effect of vitiligo on the choroid of the eye.Methods: We cross-sectionally examined 31 right eyes of 31 vitiligo patients and 32 right eyes of 32 age- and sex-matched controls for signs of vitiligo affection and then measured the subfoveal choroidal thickness (SFCT) using spectral-domain optical coherence tomography.Results: There was a statistically significant difference between SFCT in the cases group and the control group (Mean ± SD: 251.9 ± 42.0 μm and 296.8 ± 46.4 μm, respectively, p = 0.0002). The thickness correlated negatively with age (r = − 0.5) but did not correlate significantly with disease severity or duration (r = − 0.201, − 0.1781, p = 0.2783, 0.3381, respectively). Additional examination findings included iris and fundus hypopigmented spots, and peripapillary atrophy.Conclusion: SFCT is reduced among patients with vitiligo. The clinical implications of such a finding should be studied further, and eye screening programs should be considered.Keywords: vitiligo, OCT, optical coherence tomography, choroidal thicknessFouad YASalman AGMohamed THAbdelgawad RHAHassen SIDove Medical Pressarticlevitiligooctoptical coherence tomographychoroidal thicknessOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 2265-2270 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	vitiligo oct optical coherence tomography choroidal thickness Ophthalmology RE1-994
spellingShingle	vitiligo oct optical coherence tomography choroidal thickness Ophthalmology RE1-994 Fouad YA Salman AG Mohamed TH Abdelgawad RHA Hassen SI Assessment of the Effect of Vitiligo on Subfoveal Choroidal Thickness Using Spectral-Domain Optical Coherence Tomography
description	Yousef Ahmed Fouad,1 Abdelrahman Gaber Salman,1 Thanaa Helmy Mohamed,1 Randa Hesham Ali Abdelgawad,1 Samah Ibraheem Hassen2 1Department of Ophthalmology, Faculty of Medicine, Ain Shams University, Cairo, Egypt; 2Department of Dermatology, Faculty of Medicine, Ain Shams University, Cairo, EgyptCorrespondence: Yousef Ahmed FouadDepartment of Ophthalmology, Faculty of Medicine, Ain Shams University, Ramses Street, Cairo, EgyptTel +20 1063781237Email yousef.a.fouad@gmail.comBackground: Vitiligo is a common skin condition affecting 0.5– 2% of the population. The exact etiology of the condition is unknown, but the result is autoimmune destruction of melanocytes. The eye is rich in melanocytes, especially in the retinal pigment epithelium and choroid. Little is known about the effect of vitiligo on the choroid of the eye.Methods: We cross-sectionally examined 31 right eyes of 31 vitiligo patients and 32 right eyes of 32 age- and sex-matched controls for signs of vitiligo affection and then measured the subfoveal choroidal thickness (SFCT) using spectral-domain optical coherence tomography.Results: There was a statistically significant difference between SFCT in the cases group and the control group (Mean ± SD: 251.9 ± 42.0 μm and 296.8 ± 46.4 μm, respectively, p = 0.0002). The thickness correlated negatively with age (r = − 0.5) but did not correlate significantly with disease severity or duration (r = − 0.201, − 0.1781, p = 0.2783, 0.3381, respectively). Additional examination findings included iris and fundus hypopigmented spots, and peripapillary atrophy.Conclusion: SFCT is reduced among patients with vitiligo. The clinical implications of such a finding should be studied further, and eye screening programs should be considered.Keywords: vitiligo, OCT, optical coherence tomography, choroidal thickness
format	article
author	Fouad YA Salman AG Mohamed TH Abdelgawad RHA Hassen SI
author_facet	Fouad YA Salman AG Mohamed TH Abdelgawad RHA Hassen SI
author_sort	Fouad YA
title	Assessment of the Effect of Vitiligo on Subfoveal Choroidal Thickness Using Spectral-Domain Optical Coherence Tomography
title_short	Assessment of the Effect of Vitiligo on Subfoveal Choroidal Thickness Using Spectral-Domain Optical Coherence Tomography
title_full	Assessment of the Effect of Vitiligo on Subfoveal Choroidal Thickness Using Spectral-Domain Optical Coherence Tomography
title_fullStr	Assessment of the Effect of Vitiligo on Subfoveal Choroidal Thickness Using Spectral-Domain Optical Coherence Tomography
title_full_unstemmed	Assessment of the Effect of Vitiligo on Subfoveal Choroidal Thickness Using Spectral-Domain Optical Coherence Tomography
title_sort	assessment of the effect of vitiligo on subfoveal choroidal thickness using spectral-domain optical coherence tomography
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/33151728cea94584b7789382518eb370
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Assessment of the Effect of Vitiligo on Subfoveal Choroidal Thickness Using Spectral-Domain Optical Coherence Tomography

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