Polyglutamine expansion accelerates the dynamics of ataxin-1 and does not result in aggregate formation.

Polyglutamine expansion accelerates the dynamics of ataxin-1 and does not result in aggregate formation.

<h4>Background</h4>Polyglutamine expansion disorders are caused by an expansion of the polyglutamine (polyQ) tract in the disease related protein, leading to severe neurodegeneration. All polyQ disorders are hallmarked by the presence of intracellular aggregates containing the expanded p...

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Autores principales: Hilde A Krol, Przemek M Krawczyk, Klazien S Bosch, Jacob A Aten, Elly M Hol, Eric A Reits
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2008
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/331efd107d164418ade7f1f56bb701eb
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