Relationship between spinal structural damage on radiography and bone fragility on CT in ankylosing spondylitis patients

Abstract To evaluate whether the risk of bone fragility on computed tomography (CT) (scanographic bone attenuation coefficient of the first lumbar vertebra (SBAC-L1)) is associated with the severity of spine structural involvement (mSASSS) in patients with ankylosing spondylitis (AS). This retrospec...

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Autores principales:	Marine Fauny, Frank Verhoeven, Edem Allado, Eliane Albuisson, Astrid Pinzano, Caroline Morizot, Isabelle Chary-Valckenaere, Damien Loeuille
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/331f0ad7ae804bae9fdeec791037b57c
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spelling	oai:doaj.org-article:331f0ad7ae804bae9fdeec791037b57c2021-12-02T17:20:12ZRelationship between spinal structural damage on radiography and bone fragility on CT in ankylosing spondylitis patients10.1038/s41598-021-88838-92045-2322https://doaj.org/article/331f0ad7ae804bae9fdeec791037b57c2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88838-9https://doaj.org/toc/2045-2322Abstract To evaluate whether the risk of bone fragility on computed tomography (CT) (scanographic bone attenuation coefficient of the first lumbar vertebra (SBAC-L1)) is associated with the severity of spine structural involvement (mSASSS) in patients with ankylosing spondylitis (AS). This retrospective study included AS patients, followed from 2009 to 2017, who fulfilled the New York criteria and who underwent thoraco-abdomino-pelvic CT and radiography (spine, pelvis). The structural involvement was retained for mSASSS ≥ 2. The SBAC-L1 was measured in Hounsfield units (HU). A SBAC-L1 ≤ 145 HU was used to define patients at risk of vertebral fracture (VF). A total of 73 AS patients were included (mean age: 60.3 (± 10.7) years, 8 women (11%), mean disease duration: 24.6 years (± 13.9)). Sixty patients (82.2%) had a mSASSS ≥ 2 (mean score 20.7 (± 21.2)). The mean SBAC-L1 was 141.1 HU (± 45), 138.1 HU (± 44.8) and 154.8 HU (± 44.9) in the total, mSASSS ≥ 2 and mSASSS < 2 populations, respectively. Patients with bone bridges had lower SBAC-L1 than mSASSS ≥ 2 patients without ankylosis (p = 0.02) and more often SBAC-L1 ≤ 145 HU (73% vs 41.9%, p = 0.006). A SBAC-L1 ≤ 145 HU was not associated with structural spine involvement, but patients with bone bridges had significantly decreased SBAC-L1 and an increased probability of being under the fracture threshold.Marine FaunyFrank VerhoevenEdem AlladoEliane AlbuissonAstrid PinzanoCaroline MorizotIsabelle Chary-ValckenaereDamien LoeuilleNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marine Fauny Frank Verhoeven Edem Allado Eliane Albuisson Astrid Pinzano Caroline Morizot Isabelle Chary-Valckenaere Damien Loeuille Relationship between spinal structural damage on radiography and bone fragility on CT in ankylosing spondylitis patients
description	Abstract To evaluate whether the risk of bone fragility on computed tomography (CT) (scanographic bone attenuation coefficient of the first lumbar vertebra (SBAC-L1)) is associated with the severity of spine structural involvement (mSASSS) in patients with ankylosing spondylitis (AS). This retrospective study included AS patients, followed from 2009 to 2017, who fulfilled the New York criteria and who underwent thoraco-abdomino-pelvic CT and radiography (spine, pelvis). The structural involvement was retained for mSASSS ≥ 2. The SBAC-L1 was measured in Hounsfield units (HU). A SBAC-L1 ≤ 145 HU was used to define patients at risk of vertebral fracture (VF). A total of 73 AS patients were included (mean age: 60.3 (± 10.7) years, 8 women (11%), mean disease duration: 24.6 years (± 13.9)). Sixty patients (82.2%) had a mSASSS ≥ 2 (mean score 20.7 (± 21.2)). The mean SBAC-L1 was 141.1 HU (± 45), 138.1 HU (± 44.8) and 154.8 HU (± 44.9) in the total, mSASSS ≥ 2 and mSASSS < 2 populations, respectively. Patients with bone bridges had lower SBAC-L1 than mSASSS ≥ 2 patients without ankylosis (p = 0.02) and more often SBAC-L1 ≤ 145 HU (73% vs 41.9%, p = 0.006). A SBAC-L1 ≤ 145 HU was not associated with structural spine involvement, but patients with bone bridges had significantly decreased SBAC-L1 and an increased probability of being under the fracture threshold.
format	article
author	Marine Fauny Frank Verhoeven Edem Allado Eliane Albuisson Astrid Pinzano Caroline Morizot Isabelle Chary-Valckenaere Damien Loeuille
author_facet	Marine Fauny Frank Verhoeven Edem Allado Eliane Albuisson Astrid Pinzano Caroline Morizot Isabelle Chary-Valckenaere Damien Loeuille
author_sort	Marine Fauny
title	Relationship between spinal structural damage on radiography and bone fragility on CT in ankylosing spondylitis patients
title_short	Relationship between spinal structural damage on radiography and bone fragility on CT in ankylosing spondylitis patients
title_full	Relationship between spinal structural damage on radiography and bone fragility on CT in ankylosing spondylitis patients
title_fullStr	Relationship between spinal structural damage on radiography and bone fragility on CT in ankylosing spondylitis patients
title_full_unstemmed	Relationship between spinal structural damage on radiography and bone fragility on CT in ankylosing spondylitis patients
title_sort	relationship between spinal structural damage on radiography and bone fragility on ct in ankylosing spondylitis patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/331f0ad7ae804bae9fdeec791037b57c
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Relationship between spinal structural damage on radiography and bone fragility on CT in ankylosing spondylitis patients

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