Species-specific gamete recognition initiates fusion-driving trimer formation by conserved fusogen HAP2

HAP2 is essential for gamete fusion during fertilization and is conserved among eukaryotes. Here the authors show that species-specific adhesion between Chlamydomonas plus and minus gametes initiates HAP2 to undergo a fusogenic conformational change into homotrimers via a molecular mechanism akin to...

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Autores principales:	Jun Zhang, Jennifer F. Pinello, Ignacio Fernández, Eduard Baquero, Juliette Fedry, Félix A. Rey, William J. Snell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/332183e39cc842d0b8b505ff83c67ce6
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spelling	oai:doaj.org-article:332183e39cc842d0b8b505ff83c67ce62021-12-02T17:56:57ZSpecies-specific gamete recognition initiates fusion-driving trimer formation by conserved fusogen HAP210.1038/s41467-021-24613-82041-1723https://doaj.org/article/332183e39cc842d0b8b505ff83c67ce62021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24613-8https://doaj.org/toc/2041-1723HAP2 is essential for gamete fusion during fertilization and is conserved among eukaryotes. Here the authors show that species-specific adhesion between Chlamydomonas plus and minus gametes initiates HAP2 to undergo a fusogenic conformational change into homotrimers via a molecular mechanism akin to that of enveloped viruses.Jun ZhangJennifer F. PinelloIgnacio FernándezEduard BaqueroJuliette FedryFélix A. ReyWilliam J. SnellNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jun Zhang Jennifer F. Pinello Ignacio Fernández Eduard Baquero Juliette Fedry Félix A. Rey William J. Snell Species-specific gamete recognition initiates fusion-driving trimer formation by conserved fusogen HAP2
description	HAP2 is essential for gamete fusion during fertilization and is conserved among eukaryotes. Here the authors show that species-specific adhesion between Chlamydomonas plus and minus gametes initiates HAP2 to undergo a fusogenic conformational change into homotrimers via a molecular mechanism akin to that of enveloped viruses.
format	article
author	Jun Zhang Jennifer F. Pinello Ignacio Fernández Eduard Baquero Juliette Fedry Félix A. Rey William J. Snell
author_facet	Jun Zhang Jennifer F. Pinello Ignacio Fernández Eduard Baquero Juliette Fedry Félix A. Rey William J. Snell
author_sort	Jun Zhang
title	Species-specific gamete recognition initiates fusion-driving trimer formation by conserved fusogen HAP2
title_short	Species-specific gamete recognition initiates fusion-driving trimer formation by conserved fusogen HAP2
title_full	Species-specific gamete recognition initiates fusion-driving trimer formation by conserved fusogen HAP2
title_fullStr	Species-specific gamete recognition initiates fusion-driving trimer formation by conserved fusogen HAP2
title_full_unstemmed	Species-specific gamete recognition initiates fusion-driving trimer formation by conserved fusogen HAP2
title_sort	species-specific gamete recognition initiates fusion-driving trimer formation by conserved fusogen hap2
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/332183e39cc842d0b8b505ff83c67ce6
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Species-specific gamete recognition initiates fusion-driving trimer formation by conserved fusogen HAP2

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