Species-specific gamete recognition initiates fusion-driving trimer formation by conserved fusogen HAP2

HAP2 is essential for gamete fusion during fertilization and is conserved among eukaryotes. Here the authors show that species-specific adhesion between Chlamydomonas plus and minus gametes initiates HAP2 to undergo a fusogenic conformational change into homotrimers via a molecular mechanism akin to...

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Autores principales: Jun Zhang, Jennifer F. Pinello, Ignacio Fernández, Eduard Baquero, Juliette Fedry, Félix A. Rey, William J. Snell
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/332183e39cc842d0b8b505ff83c67ce6
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