Shelterin Complex at Telomeres: Implications in Ageing

Seyed Mostafa Mir,1– 3 Sadra Samavarchi Tehrani,4,5 Golnaz Goodarzi,4,5 Zahra Jamalpoor,1 Jahanbakhsh Asadi,6 Nafiseh Khelghati,7 Durdi Qujeq,2,3 Mahmood Maniati8 1Trauma Research Center, AJA University of Medical Sciences, Tehran, Iran; 2Student Research Committee, Babol University of Med...

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Autores principales:	Mir SM, Samavarchi Tehrani S, Goodarzi G, Jamalpoor ‎ Z, Asadi J, Khelghati N, Qujeq D, Maniati M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	ageing sheltering complex telomeres Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/3321c9fb06f948d8a900de5fb7c432cd
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spelling	oai:doaj.org-article:3321c9fb06f948d8a900de5fb7c432cd2021-12-02T10:17:38ZShelterin Complex at Telomeres: Implications in Ageing1178-1998https://doaj.org/article/3321c9fb06f948d8a900de5fb7c432cd2020-06-01T00:00:00Zhttps://www.dovepress.com/shelterin-complex-at-telomeres-implications-in-ageing-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Seyed Mostafa Mir,1– 3 Sadra Samavarchi Tehrani,4,5 Golnaz Goodarzi,4,5 Zahra Jamalpoor,1 Jahanbakhsh Asadi,6 Nafiseh Khelghati,7 Durdi Qujeq,2,3 Mahmood Maniati8 1Trauma Research Center, AJA University of Medical Sciences, Tehran, Iran; 2Student Research Committee, Babol University of Medical Sciences, Babol, Iran; 3Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran; 4Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; 5Student Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran; 6Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran; 7Department of Clinical Biochemistry, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran; 8School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranCorrespondence: Zahra JamalpoorTrauma Research Center, AJA University of Medical Sciences, Tehran, IranTel +989126011941Email z_jamalpoor2000@yahoo.comAbstract: Different factors influence the development&lrm; and control of ageing. It is well known that progressive telomere shorting is one of the molecular mechanisms underlying ageing. The shelterin complex consists of six telomere-specific proteins which are involved in the protection of chromosome ends. More particularly, this vital complex protects the telomeres from degradation, prevents from activation of unwanted repair systems, regulates the activity of telomerase, and has a crucial role in cellular senescent and ageing-related pathologies. This review explores the organization and function of telomeric DNA along with the mechanism of telomeres during ageing, followed by a discussion of the critical role of shelterin components and their changes during ageing.Keywords: ageing, sheltering complex, telomeresMir SMSamavarchi Tehrani SGoodarzi GJamalpoor ‎ ZAsadi JKhelghati NQujeq DManiati MDove Medical Pressarticleageingsheltering complextelomeresGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 15, Pp 827-839 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	ageing sheltering complex telomeres Geriatrics RC952-954.6
spellingShingle	ageing sheltering complex telomeres Geriatrics RC952-954.6 Mir SM Samavarchi Tehrani S Goodarzi G Jamalpoor ‎ Z Asadi J Khelghati N Qujeq D Maniati M Shelterin Complex at Telomeres: Implications in Ageing
description	Seyed Mostafa Mir,1– 3 Sadra Samavarchi Tehrani,4,5 Golnaz Goodarzi,4,5 Zahra Jamalpoor,1 Jahanbakhsh Asadi,6 Nafiseh Khelghati,7 Durdi Qujeq,2,3 Mahmood Maniati8 1Trauma Research Center, AJA University of Medical Sciences, Tehran, Iran; 2Student Research Committee, Babol University of Medical Sciences, Babol, Iran; 3Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran; 4Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; 5Student Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran; 6Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran; 7Department of Clinical Biochemistry, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran; 8School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranCorrespondence: Zahra JamalpoorTrauma Research Center, AJA University of Medical Sciences, Tehran, IranTel +989126011941Email z_jamalpoor2000@yahoo.comAbstract: Different factors influence the development&lrm; and control of ageing. It is well known that progressive telomere shorting is one of the molecular mechanisms underlying ageing. The shelterin complex consists of six telomere-specific proteins which are involved in the protection of chromosome ends. More particularly, this vital complex protects the telomeres from degradation, prevents from activation of unwanted repair systems, regulates the activity of telomerase, and has a crucial role in cellular senescent and ageing-related pathologies. This review explores the organization and function of telomeric DNA along with the mechanism of telomeres during ageing, followed by a discussion of the critical role of shelterin components and their changes during ageing.Keywords: ageing, sheltering complex, telomeres
format	article
author	Mir SM Samavarchi Tehrani S Goodarzi G Jamalpoor ‎ Z Asadi J Khelghati N Qujeq D Maniati M
author_facet	Mir SM Samavarchi Tehrani S Goodarzi G Jamalpoor ‎ Z Asadi J Khelghati N Qujeq D Maniati M
author_sort	Mir SM
title	Shelterin Complex at Telomeres: Implications in Ageing
title_short	Shelterin Complex at Telomeres: Implications in Ageing
title_full	Shelterin Complex at Telomeres: Implications in Ageing
title_fullStr	Shelterin Complex at Telomeres: Implications in Ageing
title_full_unstemmed	Shelterin Complex at Telomeres: Implications in Ageing
title_sort	shelterin complex at telomeres: implications in ageing
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/3321c9fb06f948d8a900de5fb7c432cd
work_keys_str_mv	AT mirsm shelterincomplexattelomeresimplicationsinageing AT samavarchitehranis shelterincomplexattelomeresimplicationsinageing AT goodarzig shelterincomplexattelomeresimplicationsinageing AT jamalpoorz shelterincomplexattelomeresimplicationsinageing AT asadij shelterincomplexattelomeresimplicationsinageing AT khelghatin shelterincomplexattelomeresimplicationsinageing AT qujeqd shelterincomplexattelomeresimplicationsinageing AT maniatim shelterincomplexattelomeresimplicationsinageing
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Shelterin Complex at Telomeres: Implications in Ageing

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