Tumor distribution affects bladder recurrence but not survival outcome of multifocal upper tract urothelial carcinoma treated with radical nephroureterectomy

Abstract Tumor multifocality and location are prognostic factors for upper tract urothelial carcinoma (UTUC). However, confounding effects can appear when these two factors are analyzed together. Therefore, we aimed to investigate the impact of tumor distribution on the outcomes of multifocal UTUC a...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zai-Lin Sheu, Chi-Ping Huang, Chao-Hsiang Chang, Chung-Hsin Chen, Jian-Hua Hong, Han-Yu Weng, Ta-Yao Tai, Shiu-Dong Chung, Chi-Wen Lo, Thomas Y. Hsueh, Yao-Chou Tsai, Yuan-Hong Jiang, Bing-Juin Chiang, Yung-Tai Chen, Jen-Tai Lin, Wei-Yu Lin, Yeong-Chin Jou, Jen-Shu Tseng, Chia-Chang Wu, Wen‑Jeng Wu, Hsin‑Chih Yeh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/33228d68395b40a6a162535acebaca42
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:33228d68395b40a6a162535acebaca42
record_format	dspace
spelling	oai:doaj.org-article:33228d68395b40a6a162535acebaca422021-12-02T18:48:02ZTumor distribution affects bladder recurrence but not survival outcome of multifocal upper tract urothelial carcinoma treated with radical nephroureterectomy10.1038/s41598-021-98696-02045-2322https://doaj.org/article/33228d68395b40a6a162535acebaca422021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98696-0https://doaj.org/toc/2045-2322Abstract Tumor multifocality and location are prognostic factors for upper tract urothelial carcinoma (UTUC). However, confounding effects can appear when these two factors are analyzed together. Therefore, we aimed to investigate the impact of tumor distribution on the outcomes of multifocal UTUC after radical nephroureterectomy. From the 2780 UTUC patients in the Taiwan UTUC Collaboration Group, 685 UTUC cases with multifocal tumors (defined as more than one tumor lesion in unilateral upper urinary tract) were retrospectively included and divided into three groups: multiple renal pelvic tumors, multiple ureteral tumors, and synchronous renal pelvic and ureteral tumors included 164, 152, and 369 patients, respectively. We found the prevalence of carcinoma in situ was the highest in the synchronous group. In multivariate survival analyses, tumor distribution showed no difference in cancer-specific and disease-free survival, but there was a significant difference in bladder recurrence-free survival. The synchronous group had the highest bladder recurrence rate. In summary, tumor distribution did not influence the cancer-specific outcomes of multifocal UTUC, but synchronous lesions led to a higher rate of bladder recurrence than multiple renal pelvic tumors. We believe that the distribution of tumors reflects the degree of malignant involvement within the urinary tract, but has little significance for survival or disease progression.Zai-Lin SheuChi-Ping HuangChao-Hsiang ChangChung-Hsin ChenJian-Hua HongHan-Yu WengTa-Yao TaiShiu-Dong ChungChi-Wen LoThomas Y. HsuehYao-Chou TsaiYuan-Hong JiangBing-Juin ChiangYung-Tai ChenJen-Tai LinWei-Yu LinYeong-Chin JouJen-Shu TsengChia-Chang WuWen‑Jeng WuHsin‑Chih YehNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zai-Lin Sheu Chi-Ping Huang Chao-Hsiang Chang Chung-Hsin Chen Jian-Hua Hong Han-Yu Weng Ta-Yao Tai Shiu-Dong Chung Chi-Wen Lo Thomas Y. Hsueh Yao-Chou Tsai Yuan-Hong Jiang Bing-Juin Chiang Yung-Tai Chen Jen-Tai Lin Wei-Yu Lin Yeong-Chin Jou Jen-Shu Tseng Chia-Chang Wu Wen‑Jeng Wu Hsin‑Chih Yeh Tumor distribution affects bladder recurrence but not survival outcome of multifocal upper tract urothelial carcinoma treated with radical nephroureterectomy
description	Abstract Tumor multifocality and location are prognostic factors for upper tract urothelial carcinoma (UTUC). However, confounding effects can appear when these two factors are analyzed together. Therefore, we aimed to investigate the impact of tumor distribution on the outcomes of multifocal UTUC after radical nephroureterectomy. From the 2780 UTUC patients in the Taiwan UTUC Collaboration Group, 685 UTUC cases with multifocal tumors (defined as more than one tumor lesion in unilateral upper urinary tract) were retrospectively included and divided into three groups: multiple renal pelvic tumors, multiple ureteral tumors, and synchronous renal pelvic and ureteral tumors included 164, 152, and 369 patients, respectively. We found the prevalence of carcinoma in situ was the highest in the synchronous group. In multivariate survival analyses, tumor distribution showed no difference in cancer-specific and disease-free survival, but there was a significant difference in bladder recurrence-free survival. The synchronous group had the highest bladder recurrence rate. In summary, tumor distribution did not influence the cancer-specific outcomes of multifocal UTUC, but synchronous lesions led to a higher rate of bladder recurrence than multiple renal pelvic tumors. We believe that the distribution of tumors reflects the degree of malignant involvement within the urinary tract, but has little significance for survival or disease progression.
format	article
author	Zai-Lin Sheu Chi-Ping Huang Chao-Hsiang Chang Chung-Hsin Chen Jian-Hua Hong Han-Yu Weng Ta-Yao Tai Shiu-Dong Chung Chi-Wen Lo Thomas Y. Hsueh Yao-Chou Tsai Yuan-Hong Jiang Bing-Juin Chiang Yung-Tai Chen Jen-Tai Lin Wei-Yu Lin Yeong-Chin Jou Jen-Shu Tseng Chia-Chang Wu Wen‑Jeng Wu Hsin‑Chih Yeh
author_facet	Zai-Lin Sheu Chi-Ping Huang Chao-Hsiang Chang Chung-Hsin Chen Jian-Hua Hong Han-Yu Weng Ta-Yao Tai Shiu-Dong Chung Chi-Wen Lo Thomas Y. Hsueh Yao-Chou Tsai Yuan-Hong Jiang Bing-Juin Chiang Yung-Tai Chen Jen-Tai Lin Wei-Yu Lin Yeong-Chin Jou Jen-Shu Tseng Chia-Chang Wu Wen‑Jeng Wu Hsin‑Chih Yeh
author_sort	Zai-Lin Sheu
title	Tumor distribution affects bladder recurrence but not survival outcome of multifocal upper tract urothelial carcinoma treated with radical nephroureterectomy
title_short	Tumor distribution affects bladder recurrence but not survival outcome of multifocal upper tract urothelial carcinoma treated with radical nephroureterectomy
title_full	Tumor distribution affects bladder recurrence but not survival outcome of multifocal upper tract urothelial carcinoma treated with radical nephroureterectomy
title_fullStr	Tumor distribution affects bladder recurrence but not survival outcome of multifocal upper tract urothelial carcinoma treated with radical nephroureterectomy
title_full_unstemmed	Tumor distribution affects bladder recurrence but not survival outcome of multifocal upper tract urothelial carcinoma treated with radical nephroureterectomy
title_sort	tumor distribution affects bladder recurrence but not survival outcome of multifocal upper tract urothelial carcinoma treated with radical nephroureterectomy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/33228d68395b40a6a162535acebaca42
work_keys_str_mv	AT zailinsheu tumordistributionaffectsbladderrecurrencebutnotsurvivaloutcomeofmultifocaluppertracturothelialcarcinomatreatedwithradicalnephroureterectomy AT chipinghuang tumordistributionaffectsbladderrecurrencebutnotsurvivaloutcomeofmultifocaluppertracturothelialcarcinomatreatedwithradicalnephroureterectomy AT chaohsiangchang tumordistributionaffectsbladderrecurrencebutnotsurvivaloutcomeofmultifocaluppertracturothelialcarcinomatreatedwithradicalnephroureterectomy AT chunghsinchen tumordistributionaffectsbladderrecurrencebutnotsurvivaloutcomeofmultifocaluppertracturothelialcarcinomatreatedwithradicalnephroureterectomy AT jianhuahong tumordistributionaffectsbladderrecurrencebutnotsurvivaloutcomeofmultifocaluppertracturothelialcarcinomatreatedwithradicalnephroureterectomy AT hanyuweng tumordistributionaffectsbladderrecurrencebutnotsurvivaloutcomeofmultifocaluppertracturothelialcarcinomatreatedwithradicalnephroureterectomy AT tayaotai tumordistributionaffectsbladderrecurrencebutnotsurvivaloutcomeofmultifocaluppertracturothelialcarcinomatreatedwithradicalnephroureterectomy AT shiudongchung tumordistributionaffectsbladderrecurrencebutnotsurvivaloutcomeofmultifocaluppertracturothelialcarcinomatreatedwithradicalnephroureterectomy AT chiwenlo tumordistributionaffectsbladderrecurrencebutnotsurvivaloutcomeofmultifocaluppertracturothelialcarcinomatreatedwithradicalnephroureterectomy AT thomasyhsueh tumordistributionaffectsbladderrecurrencebutnotsurvivaloutcomeofmultifocaluppertracturothelialcarcinomatreatedwithradicalnephroureterectomy AT yaochoutsai tumordistributionaffectsbladderrecurrencebutnotsurvivaloutcomeofmultifocaluppertracturothelialcarcinomatreatedwithradicalnephroureterectomy AT yuanhongjiang tumordistributionaffectsbladderrecurrencebutnotsurvivaloutcomeofmultifocaluppertracturothelialcarcinomatreatedwithradicalnephroureterectomy AT bingjuinchiang tumordistributionaffectsbladderrecurrencebutnotsurvivaloutcomeofmultifocaluppertracturothelialcarcinomatreatedwithradicalnephroureterectomy AT yungtaichen tumordistributionaffectsbladderrecurrencebutnotsurvivaloutcomeofmultifocaluppertracturothelialcarcinomatreatedwithradicalnephroureterectomy AT jentailin tumordistributionaffectsbladderrecurrencebutnotsurvivaloutcomeofmultifocaluppertracturothelialcarcinomatreatedwithradicalnephroureterectomy AT weiyulin tumordistributionaffectsbladderrecurrencebutnotsurvivaloutcomeofmultifocaluppertracturothelialcarcinomatreatedwithradicalnephroureterectomy AT yeongchinjou tumordistributionaffectsbladderrecurrencebutnotsurvivaloutcomeofmultifocaluppertracturothelialcarcinomatreatedwithradicalnephroureterectomy AT jenshutseng tumordistributionaffectsbladderrecurrencebutnotsurvivaloutcomeofmultifocaluppertracturothelialcarcinomatreatedwithradicalnephroureterectomy AT chiachangwu tumordistributionaffectsbladderrecurrencebutnotsurvivaloutcomeofmultifocaluppertracturothelialcarcinomatreatedwithradicalnephroureterectomy AT wenjengwu tumordistributionaffectsbladderrecurrencebutnotsurvivaloutcomeofmultifocaluppertracturothelialcarcinomatreatedwithradicalnephroureterectomy AT hsinchihyeh tumordistributionaffectsbladderrecurrencebutnotsurvivaloutcomeofmultifocaluppertracturothelialcarcinomatreatedwithradicalnephroureterectomy
_version_	1718377615052505088

Tumor distribution affects bladder recurrence but not survival outcome of multifocal upper tract urothelial carcinoma treated with radical nephroureterectomy

Ejemplares similares