Myofibroblasts in Normal and Fibrotic Liver in Different Animal Species

Myofibroblasts, cells sharing characteristics with fibroblasts and smooth muscle cells, may have a very heterogeneous origin. The myofibroblasts may be derived from a variety of sources including resident mesenchymal cells, epithelial to mesenchymal transition, as well as from circulating fibroblast...

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Autor principal:	Vladimir Kukolj
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2014
Materias:	fibrogenesis immunohistochemistry liver fibrosis myofibroblasts Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/3327c83c2c5d4251bdd4600cc7de7e32
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spelling	oai:doaj.org-article:3327c83c2c5d4251bdd4600cc7de7e322021-11-17T21:27:52ZMyofibroblasts in Normal and Fibrotic Liver in Different Animal Species1820-744810.2478/acve-2014-0038https://doaj.org/article/3327c83c2c5d4251bdd4600cc7de7e322014-12-01T00:00:00Zhttps://doi.org/10.2478/acve-2014-0038https://doaj.org/toc/1820-7448Myofibroblasts, cells sharing characteristics with fibroblasts and smooth muscle cells, may have a very heterogeneous origin. The myofibroblasts may be derived from a variety of sources including resident mesenchymal cells, epithelial to mesenchymal transition, as well as from circulating fibroblast-like cells called fibrocytes that are derived from bone-marrow stem cells, or derived from bone marrow precursors. In normal conditions, fibroblastic cells exhibit a low extracellular matrix production ability. After tissue injury, they become activated by cytokines locally released from inflammatory and resident cells to migrate into the damaged tissue and to synthesize extracellular matrix components. The investigation of cytoskeletal and cell surface markers showed a certain degree of heterogeneity of these cells. The reason for this is that markers these cells express to a large extent depend on the type of animal, age and stage of development of fibrosis. A better knowledge of the molecular mechanisms involved in the appearance of differentiated myofibroblasts in different pathological situations will be useful for understanding the development of fibrosis, its prevention and therapyVladimir KukoljSciendoarticlefibrogenesisimmunohistochemistryliver fibrosismyofibroblastsVeterinary medicineSF600-1100ENActa Veterinaria, Vol 64, Iss 4, Pp 397-412 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	fibrogenesis immunohistochemistry liver fibrosis myofibroblasts Veterinary medicine SF600-1100
spellingShingle	fibrogenesis immunohistochemistry liver fibrosis myofibroblasts Veterinary medicine SF600-1100 Vladimir Kukolj Myofibroblasts in Normal and Fibrotic Liver in Different Animal Species
description	Myofibroblasts, cells sharing characteristics with fibroblasts and smooth muscle cells, may have a very heterogeneous origin. The myofibroblasts may be derived from a variety of sources including resident mesenchymal cells, epithelial to mesenchymal transition, as well as from circulating fibroblast-like cells called fibrocytes that are derived from bone-marrow stem cells, or derived from bone marrow precursors. In normal conditions, fibroblastic cells exhibit a low extracellular matrix production ability. After tissue injury, they become activated by cytokines locally released from inflammatory and resident cells to migrate into the damaged tissue and to synthesize extracellular matrix components. The investigation of cytoskeletal and cell surface markers showed a certain degree of heterogeneity of these cells. The reason for this is that markers these cells express to a large extent depend on the type of animal, age and stage of development of fibrosis. A better knowledge of the molecular mechanisms involved in the appearance of differentiated myofibroblasts in different pathological situations will be useful for understanding the development of fibrosis, its prevention and therapy
format	article
author	Vladimir Kukolj
author_facet	Vladimir Kukolj
author_sort	Vladimir Kukolj
title	Myofibroblasts in Normal and Fibrotic Liver in Different Animal Species
title_short	Myofibroblasts in Normal and Fibrotic Liver in Different Animal Species
title_full	Myofibroblasts in Normal and Fibrotic Liver in Different Animal Species
title_fullStr	Myofibroblasts in Normal and Fibrotic Liver in Different Animal Species
title_full_unstemmed	Myofibroblasts in Normal and Fibrotic Liver in Different Animal Species
title_sort	myofibroblasts in normal and fibrotic liver in different animal species
publisher	Sciendo
publishDate	2014
url	https://doaj.org/article/3327c83c2c5d4251bdd4600cc7de7e32
work_keys_str_mv	AT vladimirkukolj myofibroblastsinnormalandfibroticliverindifferentanimalspecies
_version_	1718425276257402880

Myofibroblasts in Normal and Fibrotic Liver in Different Animal Species

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