Temporal trajectory of biofluid markers in Parkinson’s disease

Abstract Full dynamics of biofluid biomarkers have been unknown in patients with Parkinson’s disease (PD). Using data from 396 PD patients and 182 controls in the Parkinson's Progression Markers Initiative (PPMI) database, we estimated long-term temporal trajectories of CSF α-synuclein (α-syn),...

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Autores principales:	Min Seok Baek, Myung Jun Lee, Han-Kyeol Kim, Chul Hyoung Lyoo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3329831da03a431783222c65d4549c3b
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spelling	oai:doaj.org-article:3329831da03a431783222c65d4549c3b2021-12-02T17:56:56ZTemporal trajectory of biofluid markers in Parkinson’s disease10.1038/s41598-021-94345-82045-2322https://doaj.org/article/3329831da03a431783222c65d4549c3b2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94345-8https://doaj.org/toc/2045-2322Abstract Full dynamics of biofluid biomarkers have been unknown in patients with Parkinson’s disease (PD). Using data from 396 PD patients and 182 controls in the Parkinson's Progression Markers Initiative (PPMI) database, we estimated long-term temporal trajectories of CSF α-synuclein (α-syn), amyloid-β (Aβ), total tau (t-tau), phosphorylated tau (p-tau) and serum neurofilament light chain (NfL) by integrating function between the baseline levels and annual changes. At baseline, PD patients showed lower CSF α-syn, Aβ, t-tau and p-tau levels than those of the controls. In all PD patients, CSF α-syn and Aβ decreased in a negative exponential pattern before the onset of motor symptoms, whereas CSF t-tau and p-tau, and serum NfL increased. Patients with cognitive impairment exhibited faster decline of Aβ and α-syn and faster rise of t-tau, p-tau and NfL, when compared to those without. Similarly, low Aβ group showed earlier decline of α-syn, faster rise of t-tau, p-tau and NfL, and faster decline of cognitive performances, when compared to high Aβ group. Our results suggest that longitudinal changes in biomarkers can be influenced by cognitive impairment and Aβ burden at baseline. PD patients with Aβ pathology may be associated with early appearance of α-synuclein pathology, rapid progression of axonal degeneration and neurodegeneration, and consequently greater cognitive decline.Min Seok BaekMyung Jun LeeHan-Kyeol KimChul Hyoung LyooNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Min Seok Baek Myung Jun Lee Han-Kyeol Kim Chul Hyoung Lyoo Temporal trajectory of biofluid markers in Parkinson’s disease
description	Abstract Full dynamics of biofluid biomarkers have been unknown in patients with Parkinson’s disease (PD). Using data from 396 PD patients and 182 controls in the Parkinson's Progression Markers Initiative (PPMI) database, we estimated long-term temporal trajectories of CSF α-synuclein (α-syn), amyloid-β (Aβ), total tau (t-tau), phosphorylated tau (p-tau) and serum neurofilament light chain (NfL) by integrating function between the baseline levels and annual changes. At baseline, PD patients showed lower CSF α-syn, Aβ, t-tau and p-tau levels than those of the controls. In all PD patients, CSF α-syn and Aβ decreased in a negative exponential pattern before the onset of motor symptoms, whereas CSF t-tau and p-tau, and serum NfL increased. Patients with cognitive impairment exhibited faster decline of Aβ and α-syn and faster rise of t-tau, p-tau and NfL, when compared to those without. Similarly, low Aβ group showed earlier decline of α-syn, faster rise of t-tau, p-tau and NfL, and faster decline of cognitive performances, when compared to high Aβ group. Our results suggest that longitudinal changes in biomarkers can be influenced by cognitive impairment and Aβ burden at baseline. PD patients with Aβ pathology may be associated with early appearance of α-synuclein pathology, rapid progression of axonal degeneration and neurodegeneration, and consequently greater cognitive decline.
format	article
author	Min Seok Baek Myung Jun Lee Han-Kyeol Kim Chul Hyoung Lyoo
author_facet	Min Seok Baek Myung Jun Lee Han-Kyeol Kim Chul Hyoung Lyoo
author_sort	Min Seok Baek
title	Temporal trajectory of biofluid markers in Parkinson’s disease
title_short	Temporal trajectory of biofluid markers in Parkinson’s disease
title_full	Temporal trajectory of biofluid markers in Parkinson’s disease
title_fullStr	Temporal trajectory of biofluid markers in Parkinson’s disease
title_full_unstemmed	Temporal trajectory of biofluid markers in Parkinson’s disease
title_sort	temporal trajectory of biofluid markers in parkinson’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3329831da03a431783222c65d4549c3b
work_keys_str_mv	AT minseokbaek temporaltrajectoryofbiofluidmarkersinparkinsonsdisease AT myungjunlee temporaltrajectoryofbiofluidmarkersinparkinsonsdisease AT hankyeolkim temporaltrajectoryofbiofluidmarkersinparkinsonsdisease AT chulhyounglyoo temporaltrajectoryofbiofluidmarkersinparkinsonsdisease
_version_	1718379037785587712

Temporal trajectory of biofluid markers in Parkinson’s disease

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