Risk factors for renal involvement in Henoch–Schönlein purpura

Objective: Henoch–Schönlein purpura is a systemic vasculitis that mainly occurs in children. Renal impairment is a major complication of Henoch–Schönlein purpura, but there is no established predictive marker for renal involvement. Thus, in this study, we investigated the risk factors for renal invo...

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Autores principales:	Woo Kyung Kim, Chan Jong Kim, Eun Mi Yang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Henoch–Schönlein purpura Nephritis Blood neutrophil-to-lymphocyte ratio Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/332d60bdb5ba47768c66b29d22db0ad7
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spelling	oai:doaj.org-article:332d60bdb5ba47768c66b29d22db0ad72021-11-06T04:13:05ZRisk factors for renal involvement in Henoch–Schönlein purpura0021-755710.1016/j.jped.2021.01.008https://doaj.org/article/332d60bdb5ba47768c66b29d22db0ad72021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0021755721000383https://doaj.org/toc/0021-7557Objective: Henoch–Schönlein purpura is a systemic vasculitis that mainly occurs in children. Renal impairment is a major complication of Henoch–Schönlein purpura, but there is no established predictive marker for renal involvement. Thus, in this study, we investigated the risk factors for renal involvement in children with Henoch–Schönlein purpura. Method: The medical records of children newly diagnosed as having Henoch–Schönlein purpura between 2005 and 2020 were reviewed retrospectively. Selected laboratory data were recorded before treatment initiation. The date and the age at diagnosis; sex; and the presence of arthralgia, gastrointestinal and renal involvement were obtained retrospectively. Results: This study included a total of 186 patients with Henoch–Schönlein purpura. Among them, 36.0% had renal involvement; 28.4% had only microscopic hematuria, 53.7% had non-nephrotic range proteinuria, and 17.9% had nephrotic-range proteinuria during follow-up. The mean age was higher (p = 0.016) and female sex was predominant (p = 0.001) in patients with renal involvement than in those without renal involvement. Blood neutrophil/lymphocyte ratio (p = 0.002) and platelet/lymphocyte ratio (p = 0.002) were significantly higher than that of the patients without renal involvement. No statistically significant differences were observed in the hemoglobin concentration, platelet count, presence of arthralgia, and gastrointestinal involvement between patients with and without renal involvement. Logistic regression analysis revealed female sex (odd ratio = 3.213) and neutrophil/lymphocyte ratio (odd ratio = 1.329) as risk factors for renal involvement. Conclusions: Female sex and high neutrophil/lymphocyte ratio were risk factors for renal involvement in Henoch–Schönlein purpura.Woo Kyung KimChan Jong KimEun Mi YangElsevierarticleHenoch–Schönlein purpuraNephritisBlood neutrophil-to-lymphocyte ratioPediatricsRJ1-570ENJornal de Pediatria, Vol 97, Iss 6, Pp 646-650 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Henoch–Schönlein purpura Nephritis Blood neutrophil-to-lymphocyte ratio Pediatrics RJ1-570
spellingShingle	Henoch–Schönlein purpura Nephritis Blood neutrophil-to-lymphocyte ratio Pediatrics RJ1-570 Woo Kyung Kim Chan Jong Kim Eun Mi Yang Risk factors for renal involvement in Henoch–Schönlein purpura
description	Objective: Henoch–Schönlein purpura is a systemic vasculitis that mainly occurs in children. Renal impairment is a major complication of Henoch–Schönlein purpura, but there is no established predictive marker for renal involvement. Thus, in this study, we investigated the risk factors for renal involvement in children with Henoch–Schönlein purpura. Method: The medical records of children newly diagnosed as having Henoch–Schönlein purpura between 2005 and 2020 were reviewed retrospectively. Selected laboratory data were recorded before treatment initiation. The date and the age at diagnosis; sex; and the presence of arthralgia, gastrointestinal and renal involvement were obtained retrospectively. Results: This study included a total of 186 patients with Henoch–Schönlein purpura. Among them, 36.0% had renal involvement; 28.4% had only microscopic hematuria, 53.7% had non-nephrotic range proteinuria, and 17.9% had nephrotic-range proteinuria during follow-up. The mean age was higher (p = 0.016) and female sex was predominant (p = 0.001) in patients with renal involvement than in those without renal involvement. Blood neutrophil/lymphocyte ratio (p = 0.002) and platelet/lymphocyte ratio (p = 0.002) were significantly higher than that of the patients without renal involvement. No statistically significant differences were observed in the hemoglobin concentration, platelet count, presence of arthralgia, and gastrointestinal involvement between patients with and without renal involvement. Logistic regression analysis revealed female sex (odd ratio = 3.213) and neutrophil/lymphocyte ratio (odd ratio = 1.329) as risk factors for renal involvement. Conclusions: Female sex and high neutrophil/lymphocyte ratio were risk factors for renal involvement in Henoch–Schönlein purpura.
format	article
author	Woo Kyung Kim Chan Jong Kim Eun Mi Yang
author_facet	Woo Kyung Kim Chan Jong Kim Eun Mi Yang
author_sort	Woo Kyung Kim
title	Risk factors for renal involvement in Henoch–Schönlein purpura
title_short	Risk factors for renal involvement in Henoch–Schönlein purpura
title_full	Risk factors for renal involvement in Henoch–Schönlein purpura
title_fullStr	Risk factors for renal involvement in Henoch–Schönlein purpura
title_full_unstemmed	Risk factors for renal involvement in Henoch–Schönlein purpura
title_sort	risk factors for renal involvement in henoch–schönlein purpura
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/332d60bdb5ba47768c66b29d22db0ad7
work_keys_str_mv	AT wookyungkim riskfactorsforrenalinvolvementinhenochschonleinpurpura AT chanjongkim riskfactorsforrenalinvolvementinhenochschonleinpurpura AT eunmiyang riskfactorsforrenalinvolvementinhenochschonleinpurpura
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Risk factors for renal involvement in Henoch–Schönlein purpura

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