Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors

A role for Slit/Robo signalling in pancreas development has not been defined. Here, the authors generate Robo1/Robo2 knockout mice to identify both as needed for establishing initial pancreatic cell identity as well as for proliferation and survival of pancreatic progenitors.

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Autores principales:	Sophie Escot, David Willnow, Heike Naumann, Silvia Di Francescantonio, Francesca M. Spagnoli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3333c45137184a129f28864d1c262e72
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spelling	oai:doaj.org-article:3333c45137184a129f28864d1c262e722021-12-02T16:50:12ZRobo signalling controls pancreatic progenitor identity by regulating Tead transcription factors10.1038/s41467-018-07474-62041-1723https://doaj.org/article/3333c45137184a129f28864d1c262e722018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07474-6https://doaj.org/toc/2041-1723A role for Slit/Robo signalling in pancreas development has not been defined. Here, the authors generate Robo1/Robo2 knockout mice to identify both as needed for establishing initial pancreatic cell identity as well as for proliferation and survival of pancreatic progenitors.Sophie EscotDavid WillnowHeike NaumannSilvia Di FrancescantonioFrancesca M. SpagnoliNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sophie Escot David Willnow Heike Naumann Silvia Di Francescantonio Francesca M. Spagnoli Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors
description	A role for Slit/Robo signalling in pancreas development has not been defined. Here, the authors generate Robo1/Robo2 knockout mice to identify both as needed for establishing initial pancreatic cell identity as well as for proliferation and survival of pancreatic progenitors.
format	article
author	Sophie Escot David Willnow Heike Naumann Silvia Di Francescantonio Francesca M. Spagnoli
author_facet	Sophie Escot David Willnow Heike Naumann Silvia Di Francescantonio Francesca M. Spagnoli
author_sort	Sophie Escot
title	Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors
title_short	Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors
title_full	Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors
title_fullStr	Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors
title_full_unstemmed	Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors
title_sort	robo signalling controls pancreatic progenitor identity by regulating tead transcription factors
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3333c45137184a129f28864d1c262e72
work_keys_str_mv	AT sophieescot robosignallingcontrolspancreaticprogenitoridentitybyregulatingteadtranscriptionfactors AT davidwillnow robosignallingcontrolspancreaticprogenitoridentitybyregulatingteadtranscriptionfactors AT heikenaumann robosignallingcontrolspancreaticprogenitoridentitybyregulatingteadtranscriptionfactors AT silviadifrancescantonio robosignallingcontrolspancreaticprogenitoridentitybyregulatingteadtranscriptionfactors AT francescamspagnoli robosignallingcontrolspancreaticprogenitoridentitybyregulatingteadtranscriptionfactors
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Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors

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