Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors
A role for Slit/Robo signalling in pancreas development has not been defined. Here, the authors generate Robo1/Robo2 knockout mice to identify both as needed for establishing initial pancreatic cell identity as well as for proliferation and survival of pancreatic progenitors.
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Autores principales: | Sophie Escot, David Willnow, Heike Naumann, Silvia Di Francescantonio, Francesca M. Spagnoli |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2018
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Materias: | |
Acceso en línea: | https://doaj.org/article/3333c45137184a129f28864d1c262e72 |
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