Circuit variability interacts with excitatory-inhibitory diversity of interneurons to regulate network encoding capacity

Abstract Local interneurons (LNs) in the Drosophila olfactory system exhibit neuronal diversity and variability, yet it is still unknown how these features impact information encoding capacity and reliability in a complex LN network. We employed two strategies to construct a diverse excitatory-inhib...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kuo-Ting Tsai, Chin-Kun Hu, Kuan-Wei Li, Wen-Liang Hwang, Ya-Hui Chou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/33348a78ba9945fb8d8278dfcddebbcb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:33348a78ba9945fb8d8278dfcddebbcb
record_format	dspace
spelling	oai:doaj.org-article:33348a78ba9945fb8d8278dfcddebbcb2021-12-02T15:08:42ZCircuit variability interacts with excitatory-inhibitory diversity of interneurons to regulate network encoding capacity10.1038/s41598-018-26286-82045-2322https://doaj.org/article/33348a78ba9945fb8d8278dfcddebbcb2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-26286-8https://doaj.org/toc/2045-2322Abstract Local interneurons (LNs) in the Drosophila olfactory system exhibit neuronal diversity and variability, yet it is still unknown how these features impact information encoding capacity and reliability in a complex LN network. We employed two strategies to construct a diverse excitatory-inhibitory neural network beginning with a ring network structure and then introduced distinct types of inhibitory interneurons and circuit variability to the simulated network. The continuity of activity within the node ensemble (oscillation pattern) was used as a readout to describe the temporal dynamics of network activity. We found that inhibitory interneurons enhance the encoding capacity by protecting the network from extremely short activation periods when the network wiring complexity is very high. In addition, distinct types of interneurons have differential effects on encoding capacity and reliability. Circuit variability may enhance the encoding reliability, with or without compromising encoding capacity. Therefore, we have described how circuit variability of interneurons may interact with excitatory-inhibitory diversity to enhance the encoding capacity and distinguishability of neural networks. In this work, we evaluate the effects of different types and degrees of connection diversity on a ring model, which may simulate interneuron networks in the Drosophila olfactory system or other biological systems.Kuo-Ting TsaiChin-Kun HuKuan-Wei LiWen-Liang HwangYa-Hui ChouNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kuo-Ting Tsai Chin-Kun Hu Kuan-Wei Li Wen-Liang Hwang Ya-Hui Chou Circuit variability interacts with excitatory-inhibitory diversity of interneurons to regulate network encoding capacity
description	Abstract Local interneurons (LNs) in the Drosophila olfactory system exhibit neuronal diversity and variability, yet it is still unknown how these features impact information encoding capacity and reliability in a complex LN network. We employed two strategies to construct a diverse excitatory-inhibitory neural network beginning with a ring network structure and then introduced distinct types of inhibitory interneurons and circuit variability to the simulated network. The continuity of activity within the node ensemble (oscillation pattern) was used as a readout to describe the temporal dynamics of network activity. We found that inhibitory interneurons enhance the encoding capacity by protecting the network from extremely short activation periods when the network wiring complexity is very high. In addition, distinct types of interneurons have differential effects on encoding capacity and reliability. Circuit variability may enhance the encoding reliability, with or without compromising encoding capacity. Therefore, we have described how circuit variability of interneurons may interact with excitatory-inhibitory diversity to enhance the encoding capacity and distinguishability of neural networks. In this work, we evaluate the effects of different types and degrees of connection diversity on a ring model, which may simulate interneuron networks in the Drosophila olfactory system or other biological systems.
format	article
author	Kuo-Ting Tsai Chin-Kun Hu Kuan-Wei Li Wen-Liang Hwang Ya-Hui Chou
author_facet	Kuo-Ting Tsai Chin-Kun Hu Kuan-Wei Li Wen-Liang Hwang Ya-Hui Chou
author_sort	Kuo-Ting Tsai
title	Circuit variability interacts with excitatory-inhibitory diversity of interneurons to regulate network encoding capacity
title_short	Circuit variability interacts with excitatory-inhibitory diversity of interneurons to regulate network encoding capacity
title_full	Circuit variability interacts with excitatory-inhibitory diversity of interneurons to regulate network encoding capacity
title_fullStr	Circuit variability interacts with excitatory-inhibitory diversity of interneurons to regulate network encoding capacity
title_full_unstemmed	Circuit variability interacts with excitatory-inhibitory diversity of interneurons to regulate network encoding capacity
title_sort	circuit variability interacts with excitatory-inhibitory diversity of interneurons to regulate network encoding capacity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/33348a78ba9945fb8d8278dfcddebbcb
work_keys_str_mv	AT kuotingtsai circuitvariabilityinteractswithexcitatoryinhibitorydiversityofinterneuronstoregulatenetworkencodingcapacity AT chinkunhu circuitvariabilityinteractswithexcitatoryinhibitorydiversityofinterneuronstoregulatenetworkencodingcapacity AT kuanweili circuitvariabilityinteractswithexcitatoryinhibitorydiversityofinterneuronstoregulatenetworkencodingcapacity AT wenlianghwang circuitvariabilityinteractswithexcitatoryinhibitorydiversityofinterneuronstoregulatenetworkencodingcapacity AT yahuichou circuitvariabilityinteractswithexcitatoryinhibitorydiversityofinterneuronstoregulatenetworkencodingcapacity
_version_	1718388051461275648

Circuit variability interacts with excitatory-inhibitory diversity of interneurons to regulate network encoding capacity

Ejemplares similares