Highly dynamic host actin reorganization around developing Plasmodium inside hepatocytes.

Plasmodium sporozoites are transmitted by Anopheles mosquitoes and infect hepatocytes, where a single sporozoite replicates into thousands of merozoites inside a parasitophorous vacuole. The nature of the Plasmodium-host cell interface, as well as the interactions occurring between these two organis...

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Autores principales:	Carina S S Gomes-Santos, Maurice A Itoe, Cristina Afonso, Ricardo Henriques, Rui Gardner, Nuno Sepúlveda, Pedro D Simões, Helena Raquel, António Paulo Almeida, Luis F Moita, Friedrich Frischknecht, Maria M Mota
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3339030c475a4a1da1c43c6580d1e131
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id	oai:doaj.org-article:3339030c475a4a1da1c43c6580d1e131
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spelling	oai:doaj.org-article:3339030c475a4a1da1c43c6580d1e1312021-11-18T07:30:48ZHighly dynamic host actin reorganization around developing Plasmodium inside hepatocytes.1932-620310.1371/journal.pone.0029408https://doaj.org/article/3339030c475a4a1da1c43c6580d1e1312012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22238609/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Plasmodium sporozoites are transmitted by Anopheles mosquitoes and infect hepatocytes, where a single sporozoite replicates into thousands of merozoites inside a parasitophorous vacuole. The nature of the Plasmodium-host cell interface, as well as the interactions occurring between these two organisms, remains largely unknown. Here we show that highly dynamic hepatocyte actin reorganization events occur around developing Plasmodium berghei parasites inside human hepatoma cells. Actin reorganization is most prominent between 10 to 16 hours post infection and depends on the actin severing and capping protein, gelsolin. Live cell imaging studies also suggest that the hepatocyte cytoskeleton may contribute to parasite elimination during Plasmodium development in the liver.Carina S S Gomes-SantosMaurice A ItoeCristina AfonsoRicardo HenriquesRui GardnerNuno SepúlvedaPedro D SimõesHelena RaquelAntónio Paulo AlmeidaLuis F MoitaFriedrich FrischknechtMaria M MotaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 1, p e29408 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Carina S S Gomes-Santos Maurice A Itoe Cristina Afonso Ricardo Henriques Rui Gardner Nuno Sepúlveda Pedro D Simões Helena Raquel António Paulo Almeida Luis F Moita Friedrich Frischknecht Maria M Mota Highly dynamic host actin reorganization around developing Plasmodium inside hepatocytes.
description	Plasmodium sporozoites are transmitted by Anopheles mosquitoes and infect hepatocytes, where a single sporozoite replicates into thousands of merozoites inside a parasitophorous vacuole. The nature of the Plasmodium-host cell interface, as well as the interactions occurring between these two organisms, remains largely unknown. Here we show that highly dynamic hepatocyte actin reorganization events occur around developing Plasmodium berghei parasites inside human hepatoma cells. Actin reorganization is most prominent between 10 to 16 hours post infection and depends on the actin severing and capping protein, gelsolin. Live cell imaging studies also suggest that the hepatocyte cytoskeleton may contribute to parasite elimination during Plasmodium development in the liver.
format	article
author	Carina S S Gomes-Santos Maurice A Itoe Cristina Afonso Ricardo Henriques Rui Gardner Nuno Sepúlveda Pedro D Simões Helena Raquel António Paulo Almeida Luis F Moita Friedrich Frischknecht Maria M Mota
author_facet	Carina S S Gomes-Santos Maurice A Itoe Cristina Afonso Ricardo Henriques Rui Gardner Nuno Sepúlveda Pedro D Simões Helena Raquel António Paulo Almeida Luis F Moita Friedrich Frischknecht Maria M Mota
author_sort	Carina S S Gomes-Santos
title	Highly dynamic host actin reorganization around developing Plasmodium inside hepatocytes.
title_short	Highly dynamic host actin reorganization around developing Plasmodium inside hepatocytes.
title_full	Highly dynamic host actin reorganization around developing Plasmodium inside hepatocytes.
title_fullStr	Highly dynamic host actin reorganization around developing Plasmodium inside hepatocytes.
title_full_unstemmed	Highly dynamic host actin reorganization around developing Plasmodium inside hepatocytes.
title_sort	highly dynamic host actin reorganization around developing plasmodium inside hepatocytes.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/3339030c475a4a1da1c43c6580d1e131
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Highly dynamic host actin reorganization around developing Plasmodium inside hepatocytes.

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