Multifocal stimulation of the cerebro-cerebellar loop during the acquisition of a novel motor skill

Abstract Transcranial direct current stimulation (tDCS)-based interventions for augmenting motor learning are gaining interest in systems neuroscience and clinical research. Current approaches focus largely on monofocal motorcortical stimulation. Innovative stimulation protocols, accounting for moto...

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Autores principales:	Maximilian J. Wessel, Chang-hyun Park, Elena Beanato, Estelle A. Cuttaz, Jan E. Timmermann, Robert Schulz, Takuya Morishita, Philipp J. Koch, Friedhelm C. Hummel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3339638d745744c4a980719860c70593
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spelling	oai:doaj.org-article:3339638d745744c4a980719860c705932021-12-02T10:49:10ZMultifocal stimulation of the cerebro-cerebellar loop during the acquisition of a novel motor skill10.1038/s41598-021-81154-22045-2322https://doaj.org/article/3339638d745744c4a980719860c705932021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81154-2https://doaj.org/toc/2045-2322Abstract Transcranial direct current stimulation (tDCS)-based interventions for augmenting motor learning are gaining interest in systems neuroscience and clinical research. Current approaches focus largely on monofocal motorcortical stimulation. Innovative stimulation protocols, accounting for motor learning related brain network interactions also, may further enhance effect sizes. Here, we tested different stimulation approaches targeting the cerebro-cerebellar loop. Forty young, healthy participants trained a fine motor skill with concurrent tDCS in four sessions over two days, testing the following conditions: (1) monofocal motorcortical, (2) sham, (3) monofocal cerebellar, or (4) sequential multifocal motorcortico-cerebellar stimulation in a double-blind, parallel design. Skill retention was assessed after circa 10 and 20 days. Furthermore, potential underlying mechanisms were studied, applying paired-pulse transcranial magnetic stimulation and multimodal magnetic resonance imaging-based techniques. Multisession motorcortical stimulation facilitated skill acquisition, when compared with sham. The data failed to reveal beneficial effects of monofocal cerebellar or additive effects of sequential multifocal motorcortico-cerebellar stimulation. Multimodal multiple linear regression modelling identified baseline task performance and structural integrity of the bilateral superior cerebellar peduncle as the most influential predictors for training success. Multisession application of motorcortical tDCS in several daily sessions may further boost motor training efficiency. This has potential implications for future rehabilitation trials.Maximilian J. WesselChang-hyun ParkElena BeanatoEstelle A. CuttazJan E. TimmermannRobert SchulzTakuya MorishitaPhilipp J. KochFriedhelm C. HummelNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maximilian J. Wessel Chang-hyun Park Elena Beanato Estelle A. Cuttaz Jan E. Timmermann Robert Schulz Takuya Morishita Philipp J. Koch Friedhelm C. Hummel Multifocal stimulation of the cerebro-cerebellar loop during the acquisition of a novel motor skill
description	Abstract Transcranial direct current stimulation (tDCS)-based interventions for augmenting motor learning are gaining interest in systems neuroscience and clinical research. Current approaches focus largely on monofocal motorcortical stimulation. Innovative stimulation protocols, accounting for motor learning related brain network interactions also, may further enhance effect sizes. Here, we tested different stimulation approaches targeting the cerebro-cerebellar loop. Forty young, healthy participants trained a fine motor skill with concurrent tDCS in four sessions over two days, testing the following conditions: (1) monofocal motorcortical, (2) sham, (3) monofocal cerebellar, or (4) sequential multifocal motorcortico-cerebellar stimulation in a double-blind, parallel design. Skill retention was assessed after circa 10 and 20 days. Furthermore, potential underlying mechanisms were studied, applying paired-pulse transcranial magnetic stimulation and multimodal magnetic resonance imaging-based techniques. Multisession motorcortical stimulation facilitated skill acquisition, when compared with sham. The data failed to reveal beneficial effects of monofocal cerebellar or additive effects of sequential multifocal motorcortico-cerebellar stimulation. Multimodal multiple linear regression modelling identified baseline task performance and structural integrity of the bilateral superior cerebellar peduncle as the most influential predictors for training success. Multisession application of motorcortical tDCS in several daily sessions may further boost motor training efficiency. This has potential implications for future rehabilitation trials.
format	article
author	Maximilian J. Wessel Chang-hyun Park Elena Beanato Estelle A. Cuttaz Jan E. Timmermann Robert Schulz Takuya Morishita Philipp J. Koch Friedhelm C. Hummel
author_facet	Maximilian J. Wessel Chang-hyun Park Elena Beanato Estelle A. Cuttaz Jan E. Timmermann Robert Schulz Takuya Morishita Philipp J. Koch Friedhelm C. Hummel
author_sort	Maximilian J. Wessel
title	Multifocal stimulation of the cerebro-cerebellar loop during the acquisition of a novel motor skill
title_short	Multifocal stimulation of the cerebro-cerebellar loop during the acquisition of a novel motor skill
title_full	Multifocal stimulation of the cerebro-cerebellar loop during the acquisition of a novel motor skill
title_fullStr	Multifocal stimulation of the cerebro-cerebellar loop during the acquisition of a novel motor skill
title_full_unstemmed	Multifocal stimulation of the cerebro-cerebellar loop during the acquisition of a novel motor skill
title_sort	multifocal stimulation of the cerebro-cerebellar loop during the acquisition of a novel motor skill
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3339638d745744c4a980719860c70593
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Multifocal stimulation of the cerebro-cerebellar loop during the acquisition of a novel motor skill

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