The Prediction of Type 1 Diabetes in discordant and concordant families: 16 years of follow-up. Focus on the future
For 40 years, research continues to improve the forecasting methods and the development of effective and safe methods of preventing type 1 diabetes mellitus (T1DM). Аim. Prediction of the early preclinical stage of T1DM. Materials and methods. We studied the predisposing and protective haplotypes...
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Endocrinology Research Centre
2014
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oai:doaj.org-article:333a4972db0a467fb8079803e8e401d52021-11-14T09:00:19ZThe Prediction of Type 1 Diabetes in discordant and concordant families: 16 years of follow-up. Focus on the future2072-03512072-037810.14341/DM2014383-89https://doaj.org/article/333a4972db0a467fb8079803e8e401d52014-10-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/6687https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378For 40 years, research continues to improve the forecasting methods and the development of effective and safe methods of preventing type 1 diabetes mellitus (T1DM). Аim. Prediction of the early preclinical stage of T1DM. Materials and methods. We studied the predisposing and protective haplotypes (HLA-DRB1, gene DQ) together with immunological markers (ICA, GADA, IAA) in 224 discordant/concordant families. Results. At the Endocrinology Research Centre, population and family risks of the development of T1DM in Russia were calculated on the basis of population genetic approaches. The analysis of the prevalence of HLA genotypes among T1DM patients revealed that the high-risk haplotypes in the structure of genotype(s) DQ2 and/or DQ8 in combination with the others were 78%: of these genotypes DQ2/DQ8, DQ2/DQ2, and DQ8/DQ8 accounted for 35%; DQ2/X* and DQ8/X* accounted for 43%; and the low-risk genotype Х*/Х* accounted for 22%. The genotype Х/Х consisted of weaker predisposing haplotypes that were specific to the Russian population in combination with neutral haplotypes or those consisting of neutral haplotypes only. The analysis of patients with T1DM genotypes revealed that high-risk genotypes (DQ2/DQ8) were more common in ill children up to the age of 5 (33% of cases) than in T1DM children over 10 years (23%) (p=0.05). Conversely, the low-risk genotypes were significantly less likely to be found in children with manifestations of diabetes up to 5 years than in sick people over 10 years [5% and 13%, respectively (pElena Vital'evna TitovichTamara Leonidovna KuraevaOlga Nikolaevna IvanovaSvetlana Mikhailovna StepanovaValentina Alexandrovna PeterkovaIvan Ivanovich DedovEndocrinology Research Centrearticletype 1 diabetesgenetic susceptibilityhla-haplotypesgenotypesphenotypesautoantibodies to betbeta-cellsNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 17, Iss 3, Pp 83-89 (2014) |
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DOAJ |
| collection |
DOAJ |
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EN RU |
| topic |
type 1 diabetes genetic susceptibility hla-haplotypes genotypes phenotypes autoantibodies to betbeta-cells Nutritional diseases. Deficiency diseases RC620-627 |
| spellingShingle |
type 1 diabetes genetic susceptibility hla-haplotypes genotypes phenotypes autoantibodies to betbeta-cells Nutritional diseases. Deficiency diseases RC620-627 Elena Vital'evna Titovich Tamara Leonidovna Kuraeva Olga Nikolaevna Ivanova Svetlana Mikhailovna Stepanova Valentina Alexandrovna Peterkova Ivan Ivanovich Dedov The Prediction of Type 1 Diabetes in discordant and concordant families: 16 years of follow-up. Focus on the future |
| description |
For 40 years, research continues to improve the forecasting methods and the development of effective and safe methods of preventing type 1 diabetes mellitus (T1DM). Аim. Prediction of the early preclinical stage of T1DM. Materials and methods. We studied the predisposing and protective haplotypes (HLA-DRB1, gene DQ) together with immunological markers (ICA, GADA, IAA) in 224 discordant/concordant families. Results. At the Endocrinology Research Centre, population and family risks of the development of T1DM in Russia were calculated on the basis of population genetic approaches. The analysis of the prevalence of HLA genotypes among T1DM patients revealed that the high-risk haplotypes in the structure of genotype(s) DQ2 and/or DQ8 in combination with the others were 78%: of these genotypes DQ2/DQ8, DQ2/DQ2, and DQ8/DQ8 accounted for 35%; DQ2/X* and DQ8/X* accounted for 43%; and the low-risk genotype Х*/Х* accounted for 22%. The genotype Х/Х consisted of weaker predisposing haplotypes that were specific to the Russian population in combination with neutral haplotypes or those consisting of neutral haplotypes only. The analysis of patients with T1DM genotypes revealed that high-risk genotypes (DQ2/DQ8) were more common in ill children up to the age of 5 (33% of cases) than in T1DM children over 10 years (23%) (p=0.05). Conversely, the low-risk genotypes were significantly less likely to be found in children with manifestations of diabetes up to 5 years than in sick people over 10 years [5% and 13%, respectively (p |
| format |
article |
| author |
Elena Vital'evna Titovich Tamara Leonidovna Kuraeva Olga Nikolaevna Ivanova Svetlana Mikhailovna Stepanova Valentina Alexandrovna Peterkova Ivan Ivanovich Dedov |
| author_facet |
Elena Vital'evna Titovich Tamara Leonidovna Kuraeva Olga Nikolaevna Ivanova Svetlana Mikhailovna Stepanova Valentina Alexandrovna Peterkova Ivan Ivanovich Dedov |
| author_sort |
Elena Vital'evna Titovich |
| title |
The Prediction of Type 1 Diabetes in discordant and concordant families: 16 years of follow-up. Focus on the future |
| title_short |
The Prediction of Type 1 Diabetes in discordant and concordant families: 16 years of follow-up. Focus on the future |
| title_full |
The Prediction of Type 1 Diabetes in discordant and concordant families: 16 years of follow-up. Focus on the future |
| title_fullStr |
The Prediction of Type 1 Diabetes in discordant and concordant families: 16 years of follow-up. Focus on the future |
| title_full_unstemmed |
The Prediction of Type 1 Diabetes in discordant and concordant families: 16 years of follow-up. Focus on the future |
| title_sort |
prediction of type 1 diabetes in discordant and concordant families: 16 years of follow-up. focus on the future |
| publisher |
Endocrinology Research Centre |
| publishDate |
2014 |
| url |
https://doaj.org/article/333a4972db0a467fb8079803e8e401d5 |
| work_keys_str_mv |
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