Early age at menarche and metabolic cardiovascular risk factors: mediation by body composition in adulthood

Abstract Evidence suggests that early menarche increases cardiometabolic risk, and adiposity would be a possible mediator of this association. We assessed the association between age at menarche and metabolic cardiovascular risk factors and estimated the indirect effect of body composition in adulth...

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Autores principales:	Susana Bubach, Bernardo Lessa Horta, Helen Gonçalves, Maria Cecília Formoso Assunção
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3344db24e7bc4c03ae758f0c7f36619a
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spelling	oai:doaj.org-article:3344db24e7bc4c03ae758f0c7f36619a2021-12-02T15:12:51ZEarly age at menarche and metabolic cardiovascular risk factors: mediation by body composition in adulthood10.1038/s41598-020-80496-72045-2322https://doaj.org/article/3344db24e7bc4c03ae758f0c7f36619a2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80496-7https://doaj.org/toc/2045-2322Abstract Evidence suggests that early menarche increases cardiometabolic risk, and adiposity would be a possible mediator of this association. We assessed the association between age at menarche and metabolic cardiovascular risk factors and estimated the indirect effect of body composition in adulthood. In 1982, all hospital births in the city of Pelotas/Brazil, were identified and live births were examined and have been prospectively followed. At 30 years, information on age at menarche and metabolic cardiovascular risk factors was available for 1680 women. Mediation analysis was performed using G-computation to estimate the direct effect of age at menarche and the indirect effect of body composition. The prevalence of age at menarche < 12 years was 24.5% and was associated with higher mean diastolic blood pressure [β: 1.98; 95% CI: 0.56, 3.40], total cholesterol (β: 8.28; 95% CI: 2.67, 13.88), LDL-cholesterol (β: 6.53; 95% CI: 2.00, 11.07), triglycerides (β: 0.11; 95% CI: 0.03, 0.19). For diastolic blood pressure, total cholesterol, LDL-cholesterol, triglycerides, body composition assessed by fat mass index captured from 43.8 to 98.9% of the effect of early menarche, except to systolic blood pressure, HDL-cholesterol, C-reactive-protein. Suggesting that the effect of menarche age < 12 years on some metabolic cardiovascular risk factors is mediated partially by body composition in adulthood.Susana BubachBernardo Lessa HortaHelen GonçalvesMaria Cecília Formoso AssunçãoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Susana Bubach Bernardo Lessa Horta Helen Gonçalves Maria Cecília Formoso Assunção Early age at menarche and metabolic cardiovascular risk factors: mediation by body composition in adulthood
description	Abstract Evidence suggests that early menarche increases cardiometabolic risk, and adiposity would be a possible mediator of this association. We assessed the association between age at menarche and metabolic cardiovascular risk factors and estimated the indirect effect of body composition in adulthood. In 1982, all hospital births in the city of Pelotas/Brazil, were identified and live births were examined and have been prospectively followed. At 30 years, information on age at menarche and metabolic cardiovascular risk factors was available for 1680 women. Mediation analysis was performed using G-computation to estimate the direct effect of age at menarche and the indirect effect of body composition. The prevalence of age at menarche < 12 years was 24.5% and was associated with higher mean diastolic blood pressure [β: 1.98; 95% CI: 0.56, 3.40], total cholesterol (β: 8.28; 95% CI: 2.67, 13.88), LDL-cholesterol (β: 6.53; 95% CI: 2.00, 11.07), triglycerides (β: 0.11; 95% CI: 0.03, 0.19). For diastolic blood pressure, total cholesterol, LDL-cholesterol, triglycerides, body composition assessed by fat mass index captured from 43.8 to 98.9% of the effect of early menarche, except to systolic blood pressure, HDL-cholesterol, C-reactive-protein. Suggesting that the effect of menarche age < 12 years on some metabolic cardiovascular risk factors is mediated partially by body composition in adulthood.
format	article
author	Susana Bubach Bernardo Lessa Horta Helen Gonçalves Maria Cecília Formoso Assunção
author_facet	Susana Bubach Bernardo Lessa Horta Helen Gonçalves Maria Cecília Formoso Assunção
author_sort	Susana Bubach
title	Early age at menarche and metabolic cardiovascular risk factors: mediation by body composition in adulthood
title_short	Early age at menarche and metabolic cardiovascular risk factors: mediation by body composition in adulthood
title_full	Early age at menarche and metabolic cardiovascular risk factors: mediation by body composition in adulthood
title_fullStr	Early age at menarche and metabolic cardiovascular risk factors: mediation by body composition in adulthood
title_full_unstemmed	Early age at menarche and metabolic cardiovascular risk factors: mediation by body composition in adulthood
title_sort	early age at menarche and metabolic cardiovascular risk factors: mediation by body composition in adulthood
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3344db24e7bc4c03ae758f0c7f36619a
work_keys_str_mv	AT susanabubach earlyageatmenarcheandmetaboliccardiovascularriskfactorsmediationbybodycompositioninadulthood AT bernardolessahorta earlyageatmenarcheandmetaboliccardiovascularriskfactorsmediationbybodycompositioninadulthood AT helengoncalves earlyageatmenarcheandmetaboliccardiovascularriskfactorsmediationbybodycompositioninadulthood AT mariaceciliaformosoassuncao earlyageatmenarcheandmetaboliccardiovascularriskfactorsmediationbybodycompositioninadulthood
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Early age at menarche and metabolic cardiovascular risk factors: mediation by body composition in adulthood

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