TRPA1–FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p

TRPA1 has been reported to contribute lung cancer adenocarcinoma (LUAD), but the mechanisms are unclear. Here the authors propose that TRPA1/FGFR2 interaction is functional in LUAD and show that astrocytes oppose brain metastasis by mediating the downregulation of TRPA1 through exosome-delivered miR...

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Autores principales:	Jonathan Berrout, Eleni Kyriakopoulou, Lavanya Moparthi, Alexandra S. Hogea, Liza Berrout, Cristina Ivan, Mihaela Lorger, John Boyle, Chris Peers, Stephen Muench, Jacobo Elies Gomez, Xin Hu, Carolyn Hurst, Thomas Hall, Sujanitha Umamaheswaran, Laura Wesley, Mihai Gagea, Michael Shires, Iain Manfield, Margaret A. Knowles, Simon Davies, Klaus Suhling, Yurema Teijeiro Gonzalez, Neil Carragher, Kenneth Macleod, N. Joan Abbott, George A. Calin, Nikita Gamper, Peter M. Zygmunt, Zahra Timsah
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/33513ba93d3143cf9c9bd5f381eb5965
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spelling	oai:doaj.org-article:33513ba93d3143cf9c9bd5f381eb59652021-12-02T17:06:31ZTRPA1–FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p10.1038/s41467-017-00983-w2041-1723https://doaj.org/article/33513ba93d3143cf9c9bd5f381eb59652017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00983-whttps://doaj.org/toc/2041-1723TRPA1 has been reported to contribute lung cancer adenocarcinoma (LUAD), but the mechanisms are unclear. Here the authors propose that TRPA1/FGFR2 interaction is functional in LUAD and show that astrocytes oppose brain metastasis by mediating the downregulation of TRPA1 through exosome-delivered miRNA-142-3p.Jonathan BerroutEleni KyriakopoulouLavanya MoparthiAlexandra S. HogeaLiza BerroutCristina IvanMihaela LorgerJohn BoyleChris PeersStephen MuenchJacobo Elies GomezXin HuCarolyn HurstThomas HallSujanitha UmamaheswaranLaura WesleyMihai GageaMichael ShiresIain ManfieldMargaret A. KnowlesSimon DaviesKlaus SuhlingYurema Teijeiro GonzalezNeil CarragherKenneth MacleodN. Joan AbbottGeorge A. CalinNikita GamperPeter M. ZygmuntZahra TimsahNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jonathan Berrout Eleni Kyriakopoulou Lavanya Moparthi Alexandra S. Hogea Liza Berrout Cristina Ivan Mihaela Lorger John Boyle Chris Peers Stephen Muench Jacobo Elies Gomez Xin Hu Carolyn Hurst Thomas Hall Sujanitha Umamaheswaran Laura Wesley Mihai Gagea Michael Shires Iain Manfield Margaret A. Knowles Simon Davies Klaus Suhling Yurema Teijeiro Gonzalez Neil Carragher Kenneth Macleod N. Joan Abbott George A. Calin Nikita Gamper Peter M. Zygmunt Zahra Timsah TRPA1–FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p
description	TRPA1 has been reported to contribute lung cancer adenocarcinoma (LUAD), but the mechanisms are unclear. Here the authors propose that TRPA1/FGFR2 interaction is functional in LUAD and show that astrocytes oppose brain metastasis by mediating the downregulation of TRPA1 through exosome-delivered miRNA-142-3p.
format	article
author	Jonathan Berrout Eleni Kyriakopoulou Lavanya Moparthi Alexandra S. Hogea Liza Berrout Cristina Ivan Mihaela Lorger John Boyle Chris Peers Stephen Muench Jacobo Elies Gomez Xin Hu Carolyn Hurst Thomas Hall Sujanitha Umamaheswaran Laura Wesley Mihai Gagea Michael Shires Iain Manfield Margaret A. Knowles Simon Davies Klaus Suhling Yurema Teijeiro Gonzalez Neil Carragher Kenneth Macleod N. Joan Abbott George A. Calin Nikita Gamper Peter M. Zygmunt Zahra Timsah
author_facet	Jonathan Berrout Eleni Kyriakopoulou Lavanya Moparthi Alexandra S. Hogea Liza Berrout Cristina Ivan Mihaela Lorger John Boyle Chris Peers Stephen Muench Jacobo Elies Gomez Xin Hu Carolyn Hurst Thomas Hall Sujanitha Umamaheswaran Laura Wesley Mihai Gagea Michael Shires Iain Manfield Margaret A. Knowles Simon Davies Klaus Suhling Yurema Teijeiro Gonzalez Neil Carragher Kenneth Macleod N. Joan Abbott George A. Calin Nikita Gamper Peter M. Zygmunt Zahra Timsah
author_sort	Jonathan Berrout
title	TRPA1–FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p
title_short	TRPA1–FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p
title_full	TRPA1–FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p
title_fullStr	TRPA1–FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p
title_full_unstemmed	TRPA1–FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p
title_sort	trpa1–fgfr2 binding event is a regulatory oncogenic driver modulated by mirna-142-3p
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/33513ba93d3143cf9c9bd5f381eb5965
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TRPA1–FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p

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