Novel light-driven functional AgNPs induce cancer death at extra low concentrations

Abstract The current study is aimed at preparing light-driven novel functional AgNPs- bio-hydrogel and evaluating anticancer potency against human melanoma cells. With an average size of 16–18 nm, the hydrogel nano-silver particle composite (AgNPs@C_MA_O) was synthesized using a soft white LED appro...

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Autores principales:	Ulviye Bunyatova, Manel Ben Hammouda, Jennifer Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3353f82170464d9c91719d7340a01d9c
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spelling	oai:doaj.org-article:3353f82170464d9c91719d7340a01d9c2021-12-02T17:45:02ZNovel light-driven functional AgNPs induce cancer death at extra low concentrations10.1038/s41598-021-92689-92045-2322https://doaj.org/article/3353f82170464d9c91719d7340a01d9c2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92689-9https://doaj.org/toc/2045-2322Abstract The current study is aimed at preparing light-driven novel functional AgNPs- bio-hydrogel and evaluating anticancer potency against human melanoma cells. With an average size of 16–18 nm, the hydrogel nano-silver particle composite (AgNPs@C_MA_O) was synthesized using a soft white LED approach and analyzed by UV–Vis, DLS, FTIR, X-ray, SEM–EDX and TEM techniques. The anticancer activity of the obtained novel functionalized AgNPs@C_MA_O was tested in-vitro in the A375 melanoma cell line. Dose–response analysis showed that AgNPs at 0.01 mg/mL and 0.005 mg/mL doses reduced the viability of A375 cells by 50% at 24 and 48-h time-points, respectively. A375 cells treated with AgNPs@C_MA_O for 24 h at IC50 displayed abnormal morphology such as detachment edges and feet, shrinkage, membrane damage, and the loss of contact with adjacent cells. Our work is the first study showing that non-ionizing radiation mediated biofunctionalized AgNPs have an anti-tumoral effect at such a low concentration of 0.01 mg/mL. Our approach of using harmless wLED increased synergy between soft biopolymer compounds and AgNPs, and enhanced anticancer efficiency of the AgNPs@C_MA_O biohydrogel. Ultimately, the AgNPs accessed through the use of the wLED approach in colloidal syntheses can open new applications and combinatorial advanced cancer treatments and diagnostics.Ulviye BunyatovaManel Ben HammoudaJennifer ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ulviye Bunyatova Manel Ben Hammouda Jennifer Zhang Novel light-driven functional AgNPs induce cancer death at extra low concentrations
description	Abstract The current study is aimed at preparing light-driven novel functional AgNPs- bio-hydrogel and evaluating anticancer potency against human melanoma cells. With an average size of 16–18 nm, the hydrogel nano-silver particle composite (AgNPs@C_MA_O) was synthesized using a soft white LED approach and analyzed by UV–Vis, DLS, FTIR, X-ray, SEM–EDX and TEM techniques. The anticancer activity of the obtained novel functionalized AgNPs@C_MA_O was tested in-vitro in the A375 melanoma cell line. Dose–response analysis showed that AgNPs at 0.01 mg/mL and 0.005 mg/mL doses reduced the viability of A375 cells by 50% at 24 and 48-h time-points, respectively. A375 cells treated with AgNPs@C_MA_O for 24 h at IC50 displayed abnormal morphology such as detachment edges and feet, shrinkage, membrane damage, and the loss of contact with adjacent cells. Our work is the first study showing that non-ionizing radiation mediated biofunctionalized AgNPs have an anti-tumoral effect at such a low concentration of 0.01 mg/mL. Our approach of using harmless wLED increased synergy between soft biopolymer compounds and AgNPs, and enhanced anticancer efficiency of the AgNPs@C_MA_O biohydrogel. Ultimately, the AgNPs accessed through the use of the wLED approach in colloidal syntheses can open new applications and combinatorial advanced cancer treatments and diagnostics.
format	article
author	Ulviye Bunyatova Manel Ben Hammouda Jennifer Zhang
author_facet	Ulviye Bunyatova Manel Ben Hammouda Jennifer Zhang
author_sort	Ulviye Bunyatova
title	Novel light-driven functional AgNPs induce cancer death at extra low concentrations
title_short	Novel light-driven functional AgNPs induce cancer death at extra low concentrations
title_full	Novel light-driven functional AgNPs induce cancer death at extra low concentrations
title_fullStr	Novel light-driven functional AgNPs induce cancer death at extra low concentrations
title_full_unstemmed	Novel light-driven functional AgNPs induce cancer death at extra low concentrations
title_sort	novel light-driven functional agnps induce cancer death at extra low concentrations
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3353f82170464d9c91719d7340a01d9c
work_keys_str_mv	AT ulviyebunyatova novellightdrivenfunctionalagnpsinducecancerdeathatextralowconcentrations AT manelbenhammouda novellightdrivenfunctionalagnpsinducecancerdeathatextralowconcentrations AT jenniferzhang novellightdrivenfunctionalagnpsinducecancerdeathatextralowconcentrations
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Novel light-driven functional AgNPs induce cancer death at extra low concentrations

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