Preclinical development of a miR-132 inhibitor for heart failure treatment
miR-132 was shown to drive pathological cardiac remodeling, a hallmark of heart failure. Here, the authors show that an antisense inhibitor of miR-132 has favourable pharmacokinetics, safety-tolerability and preclinical efficacy in mouse and porcine models of heart failure.
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Nature Portfolio
2020
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oai:doaj.org-article:33579ddb7f504de8ad9792e4fd12c4d22021-12-02T16:50:01ZPreclinical development of a miR-132 inhibitor for heart failure treatment10.1038/s41467-020-14349-22041-1723https://doaj.org/article/33579ddb7f504de8ad9792e4fd12c4d22020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14349-2https://doaj.org/toc/2041-1723miR-132 was shown to drive pathological cardiac remodeling, a hallmark of heart failure. Here, the authors show that an antisense inhibitor of miR-132 has favourable pharmacokinetics, safety-tolerability and preclinical efficacy in mouse and porcine models of heart failure.Ariana FoinquinosSandor BatkaiCelina GenschelJanika ViereckSteffen RumpMariann GyöngyösiDenise TraxlerMartin RiesenhuberAndreas SpannbauerDominika LukovicNatalie WeberKatrin ZlabingerEna HašimbegovićJohannes WinklerJan FiedlerSeema DangwalMartin FischerJeanne de la RocheDaniel WojciechowskiTheresia KraftRita GaramvölgyiSonja NeitzelShambhabi ChatterjeeXiaoke YinChristian BärManuel MayrKe XiaoThomas ThumNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Ariana Foinquinos Sandor Batkai Celina Genschel Janika Viereck Steffen Rump Mariann Gyöngyösi Denise Traxler Martin Riesenhuber Andreas Spannbauer Dominika Lukovic Natalie Weber Katrin Zlabinger Ena Hašimbegović Johannes Winkler Jan Fiedler Seema Dangwal Martin Fischer Jeanne de la Roche Daniel Wojciechowski Theresia Kraft Rita Garamvölgyi Sonja Neitzel Shambhabi Chatterjee Xiaoke Yin Christian Bär Manuel Mayr Ke Xiao Thomas Thum Preclinical development of a miR-132 inhibitor for heart failure treatment |
| description |
miR-132 was shown to drive pathological cardiac remodeling, a hallmark of heart failure. Here, the authors show that an antisense inhibitor of miR-132 has favourable pharmacokinetics, safety-tolerability and preclinical efficacy in mouse and porcine models of heart failure. |
| format |
article |
| author |
Ariana Foinquinos Sandor Batkai Celina Genschel Janika Viereck Steffen Rump Mariann Gyöngyösi Denise Traxler Martin Riesenhuber Andreas Spannbauer Dominika Lukovic Natalie Weber Katrin Zlabinger Ena Hašimbegović Johannes Winkler Jan Fiedler Seema Dangwal Martin Fischer Jeanne de la Roche Daniel Wojciechowski Theresia Kraft Rita Garamvölgyi Sonja Neitzel Shambhabi Chatterjee Xiaoke Yin Christian Bär Manuel Mayr Ke Xiao Thomas Thum |
| author_facet |
Ariana Foinquinos Sandor Batkai Celina Genschel Janika Viereck Steffen Rump Mariann Gyöngyösi Denise Traxler Martin Riesenhuber Andreas Spannbauer Dominika Lukovic Natalie Weber Katrin Zlabinger Ena Hašimbegović Johannes Winkler Jan Fiedler Seema Dangwal Martin Fischer Jeanne de la Roche Daniel Wojciechowski Theresia Kraft Rita Garamvölgyi Sonja Neitzel Shambhabi Chatterjee Xiaoke Yin Christian Bär Manuel Mayr Ke Xiao Thomas Thum |
| author_sort |
Ariana Foinquinos |
| title |
Preclinical development of a miR-132 inhibitor for heart failure treatment |
| title_short |
Preclinical development of a miR-132 inhibitor for heart failure treatment |
| title_full |
Preclinical development of a miR-132 inhibitor for heart failure treatment |
| title_fullStr |
Preclinical development of a miR-132 inhibitor for heart failure treatment |
| title_full_unstemmed |
Preclinical development of a miR-132 inhibitor for heart failure treatment |
| title_sort |
preclinical development of a mir-132 inhibitor for heart failure treatment |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/33579ddb7f504de8ad9792e4fd12c4d2 |
| work_keys_str_mv |
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| _version_ |
1718383149804683264 |