An integrative method to decode regulatory logics in gene transcription

Existing transcriptional regulatory networks models fall short of deciphering the cooperation between multiple transcription factors on dynamic gene expression. Here the authors develop an integrative method that combines gene expression and transcription factor-DNA binding data to decode transcript...

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Autores principales: Bin Yan, Daogang Guan, Chao Wang, Junwen Wang, Bing He, Jing Qin, Kenneth R. Boheler, Aiping Lu, Ge Zhang, Hailong Zhu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/3358677a7c7943d98b13f54618c6ce49
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spelling oai:doaj.org-article:3358677a7c7943d98b13f54618c6ce492021-12-02T15:38:46ZAn integrative method to decode regulatory logics in gene transcription10.1038/s41467-017-01193-02041-1723https://doaj.org/article/3358677a7c7943d98b13f54618c6ce492017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01193-0https://doaj.org/toc/2041-1723Existing transcriptional regulatory networks models fall short of deciphering the cooperation between multiple transcription factors on dynamic gene expression. Here the authors develop an integrative method that combines gene expression and transcription factor-DNA binding data to decode transcription regulatory logics.Bin YanDaogang GuanChao WangJunwen WangBing HeJing QinKenneth R. BohelerAiping LuGe ZhangHailong ZhuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Bin Yan
Daogang Guan
Chao Wang
Junwen Wang
Bing He
Jing Qin
Kenneth R. Boheler
Aiping Lu
Ge Zhang
Hailong Zhu
An integrative method to decode regulatory logics in gene transcription
description Existing transcriptional regulatory networks models fall short of deciphering the cooperation between multiple transcription factors on dynamic gene expression. Here the authors develop an integrative method that combines gene expression and transcription factor-DNA binding data to decode transcription regulatory logics.
format article
author Bin Yan
Daogang Guan
Chao Wang
Junwen Wang
Bing He
Jing Qin
Kenneth R. Boheler
Aiping Lu
Ge Zhang
Hailong Zhu
author_facet Bin Yan
Daogang Guan
Chao Wang
Junwen Wang
Bing He
Jing Qin
Kenneth R. Boheler
Aiping Lu
Ge Zhang
Hailong Zhu
author_sort Bin Yan
title An integrative method to decode regulatory logics in gene transcription
title_short An integrative method to decode regulatory logics in gene transcription
title_full An integrative method to decode regulatory logics in gene transcription
title_fullStr An integrative method to decode regulatory logics in gene transcription
title_full_unstemmed An integrative method to decode regulatory logics in gene transcription
title_sort integrative method to decode regulatory logics in gene transcription
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/3358677a7c7943d98b13f54618c6ce49
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