CLINICAL AND IMMUNOLOGICAL PARAMETERS IN EARLY RHEUMATOID ARTHRITIS

Abstract. Early events in rheumatoid arthritis (RA) play a main role in development and progression of immunocomplex-associated inflammation. Early diagnostics of RА allows adequate immunosuppressive medications to stop the disease progression, to obtain more significant clinical effect and improve...

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Autores principales:	V. V. Sokolova, S. V. Lapin, A. V. Moskalev, V. I. Mazurov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	early rheumatoid arthritis cytokines antifilagrine antibodies autoantibodies Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/335ae3238b5e49c4a40b6cd47d87d99c
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spelling	oai:doaj.org-article:335ae3238b5e49c4a40b6cd47d87d99c2021-11-18T08:03:39ZCLINICAL AND IMMUNOLOGICAL PARAMETERS IN EARLY RHEUMATOID ARTHRITIS1563-06252313-741X10.15789/1563-0625-2007-6-635-642https://doaj.org/article/335ae3238b5e49c4a40b6cd47d87d99c2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/256https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Early events in rheumatoid arthritis (RA) play a main role in development and progression of immunocomplex-associated inflammation. Early diagnostics of RА allows adequate immunosuppressive medications to stop the disease progression, to obtain more significant clinical effect and improve prognosis of the disease. We examined 85 patients with early RА (less than 1 year from the onset of disease), as well as thirty patients with long-lasting RA. Twenty-six age- and sexmatched healthy donors served as a control group. Standard clinical examination was performed. In all RA patients we measured concentrations of antifilagrine antibodies (AFA) including antikeratin antibodies, antiperinuclear factor, antibodies to cyclic citrullinated peptide and serum levels of main cytokines, i.e., IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, as well as TNFα, VEGF, IFNγ, МСР-1.Rheumatoid factor (RF) was detectable in 44% patients with early RA, AFA, in 62% cases. These parameters in patients with long-lasting RA were 88% and 57% accordingly. Positive AFA were found in patients with higher expression of clinical and laboratory markers.The levels of proinflammatory cytokines such as IL-1β, IL-6 and chemokine MCP-1 were significantly elevated in patients with early and long-lasting RA in comparison with control group, but patients with longlasting RА showed the highest MCP-1 levels. The associations between severity markers of RA and serum levels of cytokines were demonstrated.Our data support important diagnostic role of АFА at the early stages of RА. Serum cytokine concentrations can be used as additional laboratory and prognostic criteria of RA.V. V. SokolovaS. V. LapinA. V. MoskalevV. I. MazurovSPb RAACIarticleearly rheumatoid arthritiscytokinesantifilagrine antibodiesautoantibodiesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 9, Iss 6, Pp 635-642 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	early rheumatoid arthritis cytokines antifilagrine antibodies autoantibodies Immunologic diseases. Allergy RC581-607
spellingShingle	early rheumatoid arthritis cytokines antifilagrine antibodies autoantibodies Immunologic diseases. Allergy RC581-607 V. V. Sokolova S. V. Lapin A. V. Moskalev V. I. Mazurov CLINICAL AND IMMUNOLOGICAL PARAMETERS IN EARLY RHEUMATOID ARTHRITIS
description	Abstract. Early events in rheumatoid arthritis (RA) play a main role in development and progression of immunocomplex-associated inflammation. Early diagnostics of RА allows adequate immunosuppressive medications to stop the disease progression, to obtain more significant clinical effect and improve prognosis of the disease. We examined 85 patients with early RА (less than 1 year from the onset of disease), as well as thirty patients with long-lasting RA. Twenty-six age- and sexmatched healthy donors served as a control group. Standard clinical examination was performed. In all RA patients we measured concentrations of antifilagrine antibodies (AFA) including antikeratin antibodies, antiperinuclear factor, antibodies to cyclic citrullinated peptide and serum levels of main cytokines, i.e., IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, as well as TNFα, VEGF, IFNγ, МСР-1.Rheumatoid factor (RF) was detectable in 44% patients with early RA, AFA, in 62% cases. These parameters in patients with long-lasting RA were 88% and 57% accordingly. Positive AFA were found in patients with higher expression of clinical and laboratory markers.The levels of proinflammatory cytokines such as IL-1β, IL-6 and chemokine MCP-1 were significantly elevated in patients with early and long-lasting RA in comparison with control group, but patients with longlasting RА showed the highest MCP-1 levels. The associations between severity markers of RA and serum levels of cytokines were demonstrated.Our data support important diagnostic role of АFА at the early stages of RА. Serum cytokine concentrations can be used as additional laboratory and prognostic criteria of RA.
format	article
author	V. V. Sokolova S. V. Lapin A. V. Moskalev V. I. Mazurov
author_facet	V. V. Sokolova S. V. Lapin A. V. Moskalev V. I. Mazurov
author_sort	V. V. Sokolova
title	CLINICAL AND IMMUNOLOGICAL PARAMETERS IN EARLY RHEUMATOID ARTHRITIS
title_short	CLINICAL AND IMMUNOLOGICAL PARAMETERS IN EARLY RHEUMATOID ARTHRITIS
title_full	CLINICAL AND IMMUNOLOGICAL PARAMETERS IN EARLY RHEUMATOID ARTHRITIS
title_fullStr	CLINICAL AND IMMUNOLOGICAL PARAMETERS IN EARLY RHEUMATOID ARTHRITIS
title_full_unstemmed	CLINICAL AND IMMUNOLOGICAL PARAMETERS IN EARLY RHEUMATOID ARTHRITIS
title_sort	clinical and immunological parameters in early rheumatoid arthritis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/335ae3238b5e49c4a40b6cd47d87d99c
work_keys_str_mv	AT vvsokolova clinicalandimmunologicalparametersinearlyrheumatoidarthritis AT svlapin clinicalandimmunologicalparametersinearlyrheumatoidarthritis AT avmoskalev clinicalandimmunologicalparametersinearlyrheumatoidarthritis AT vimazurov clinicalandimmunologicalparametersinearlyrheumatoidarthritis
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CLINICAL AND IMMUNOLOGICAL PARAMETERS IN EARLY RHEUMATOID ARTHRITIS

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