The alga Euglena gracilis stimulates Faecalibacterium in the gut and contributes to increased defecation

Abstract The alga Euglena gracilis (E. gracilis) has recently gained attention as a health food, but its effects on human gut microbiota remain unknown. This study aimed to determine the effect of E. gracilis on gut microbiota and defecation due to modulation of microbiota composition in vitro and i...

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Autores principales:	Ayaka Nakashima, Kengo Sasaki, Daisuke Sasaki, Kosuke Yasuda, Kengo Suzuki, Akihiko Kondo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/335b6cbdb81242e0b2147c55a9035a93
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spelling	oai:doaj.org-article:335b6cbdb81242e0b2147c55a9035a932021-12-02T14:01:22ZThe alga Euglena gracilis stimulates Faecalibacterium in the gut and contributes to increased defecation10.1038/s41598-020-80306-02045-2322https://doaj.org/article/335b6cbdb81242e0b2147c55a9035a932021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80306-0https://doaj.org/toc/2045-2322Abstract The alga Euglena gracilis (E. gracilis) has recently gained attention as a health food, but its effects on human gut microbiota remain unknown. This study aimed to determine the effect of E. gracilis on gut microbiota and defecation due to modulation of microbiota composition in vitro and in vivo. The in vitro model simulating human colonic microbiota revealed that E. gracilis addition stimulated the growth of commensal Faecalibacterium. Further, E. gracilis addition enhanced butyrate production by Faecalibacterium prausnitzii. Paramylon, an insoluble dietary fibre that accumulates in E. gracilis and is the main component of E. gracilis, did not stimulate Faecalibacterium growth in vitro. Daily ingestion of 2 g of E. gracilis for 30 days increased bowel movement frequency as well as stool volume in 28 human participants. Collectively, these findings indicate that E. gracilis components other than paramylon, stimulate the growth of Faecalibacterium to improve digestive health as well as promote defecation by increasing butyrate production.Ayaka NakashimaKengo SasakiDaisuke SasakiKosuke YasudaKengo SuzukiAkihiko KondoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ayaka Nakashima Kengo Sasaki Daisuke Sasaki Kosuke Yasuda Kengo Suzuki Akihiko Kondo The alga Euglena gracilis stimulates Faecalibacterium in the gut and contributes to increased defecation
description	Abstract The alga Euglena gracilis (E. gracilis) has recently gained attention as a health food, but its effects on human gut microbiota remain unknown. This study aimed to determine the effect of E. gracilis on gut microbiota and defecation due to modulation of microbiota composition in vitro and in vivo. The in vitro model simulating human colonic microbiota revealed that E. gracilis addition stimulated the growth of commensal Faecalibacterium. Further, E. gracilis addition enhanced butyrate production by Faecalibacterium prausnitzii. Paramylon, an insoluble dietary fibre that accumulates in E. gracilis and is the main component of E. gracilis, did not stimulate Faecalibacterium growth in vitro. Daily ingestion of 2 g of E. gracilis for 30 days increased bowel movement frequency as well as stool volume in 28 human participants. Collectively, these findings indicate that E. gracilis components other than paramylon, stimulate the growth of Faecalibacterium to improve digestive health as well as promote defecation by increasing butyrate production.
format	article
author	Ayaka Nakashima Kengo Sasaki Daisuke Sasaki Kosuke Yasuda Kengo Suzuki Akihiko Kondo
author_facet	Ayaka Nakashima Kengo Sasaki Daisuke Sasaki Kosuke Yasuda Kengo Suzuki Akihiko Kondo
author_sort	Ayaka Nakashima
title	The alga Euglena gracilis stimulates Faecalibacterium in the gut and contributes to increased defecation
title_short	The alga Euglena gracilis stimulates Faecalibacterium in the gut and contributes to increased defecation
title_full	The alga Euglena gracilis stimulates Faecalibacterium in the gut and contributes to increased defecation
title_fullStr	The alga Euglena gracilis stimulates Faecalibacterium in the gut and contributes to increased defecation
title_full_unstemmed	The alga Euglena gracilis stimulates Faecalibacterium in the gut and contributes to increased defecation
title_sort	alga euglena gracilis stimulates faecalibacterium in the gut and contributes to increased defecation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/335b6cbdb81242e0b2147c55a9035a93
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The alga Euglena gracilis stimulates Faecalibacterium in the gut and contributes to increased defecation

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