Changes in corneal parameters at confocal microscopy in treated glaucoma patients

Stefano Ranno1, Paolo Fogagnolo2, Luca Rossetti3, Nicola Orzalesi3, Paolo Nucci11Eye Clinic, San Giuseppe Hospital, University of Milan, Milan, Italy; 2GB Bietti Foundation for Study and Research in Ophthalmology, Rome, Italy; 3Eye Clinic, Department of Medicine, San Paolo Hospital, University of Mi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ranno S, Fogagnolo P, Rossetti L, Orzalesi N, Nucci P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/335bf70a4f034635a6b3d5b0d738579c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:335bf70a4f034635a6b3d5b0d738579c
record_format	dspace
spelling	oai:doaj.org-article:335bf70a4f034635a6b3d5b0d738579c2021-12-02T11:28:39ZChanges in corneal parameters at confocal microscopy in treated glaucoma patients1177-54671177-5483https://doaj.org/article/335bf70a4f034635a6b3d5b0d738579c2011-07-01T00:00:00Zhttp://www.dovepress.com/changes-in-corneal-parameters-at-confocal-microscopy-in-treated-glauco-a7953https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Stefano Ranno1, Paolo Fogagnolo2, Luca Rossetti3, Nicola Orzalesi3, Paolo Nucci11Eye Clinic, San Giuseppe Hospital, University of Milan, Milan, Italy; 2GB Bietti Foundation for Study and Research in Ophthalmology, Rome, Italy; 3Eye Clinic, Department of Medicine, San Paolo Hospital, University of Milan, Milan, ItalyBackground: The purpose of this study was to evaluate corneal parameters in treated glaucoma patients, nontreated glaucoma patients, and normal subjects using confocal microscopy.Methods: Forty patients with primary open-angle glaucoma and 22 untreated controls underwent confocal microscopy of the cornea using the Heidelberg retinal tomograph cornea module. The glaucoma group was divided into two subgroups, ie, patients on medical treatment for at least two years before inclusion (with beta-blockers or prostaglandin analogs) and nontreated glaucoma patients. The following corneal parameters were evaluated: endothelial cell density and number, reflectivity, and tortuosity of sub-basal nerves. For reflectivity and tortuosity, a dedicated grading scale ranging from 0 to 4 was used. Differences between treatments were also evaluated in the treated glaucoma group.Results: Number of fibers and reflectivity of the sub-basal plexus were significantly lower in glaucoma patients as compared with controls (2.5 &plusmn; 0.7 versus 2.9 &plusmn; 0.9, P = 0.006, and 2.3 &plusmn; 0.8 versus 2.7 &plusmn; 0.9, P = 0.04, respectively), whereas tortuosity was significantly higher (2.6 &plusmn; 1 versus 2.0 &plusmn; 0.8, P = 0.007). Endothelial cell density (measured as cells per mm2) was lower in the glaucoma group comparing treated patients with nontreated patients (2826 &plusmn; 285 versus 3124 &plusmn; 272, P = 0.0003). Comparing treated patients with nontreated patients, relevant differences were found in number (2.3 &plusmn; 0.7 versus 2.8 &plusmn; 0.8, P = 0.004), tortuosity (2.8 &plusmn; 1 versus 2.2 &plusmn; 0.8, P = 0.004), and reflectivity (2.2 &plusmn; 0.8 versus 2.6 &plusmn; 0.8, P = 0.04). No differences in corneal parameters were found between beta-blockers and prostaglandin analogs.Conclusion: This study shows that differences in corneal parameters between glaucoma patients and controls may be due to the medical treatments used for glaucoma. These data should be taken into consideration in long-standing medical glaucoma treatment and in potential candidates for surgery.Keywords: cornea, glaucoma, sub-basal nerves, endothelial cells, confocal microscopy&nbsp;Ranno SFogagnolo PRossetti LOrzalesi NNucci PDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2011, Iss default, Pp 1037-1042 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Ranno S Fogagnolo P Rossetti L Orzalesi N Nucci P Changes in corneal parameters at confocal microscopy in treated glaucoma patients
description	Stefano Ranno1, Paolo Fogagnolo2, Luca Rossetti3, Nicola Orzalesi3, Paolo Nucci11Eye Clinic, San Giuseppe Hospital, University of Milan, Milan, Italy; 2GB Bietti Foundation for Study and Research in Ophthalmology, Rome, Italy; 3Eye Clinic, Department of Medicine, San Paolo Hospital, University of Milan, Milan, ItalyBackground: The purpose of this study was to evaluate corneal parameters in treated glaucoma patients, nontreated glaucoma patients, and normal subjects using confocal microscopy.Methods: Forty patients with primary open-angle glaucoma and 22 untreated controls underwent confocal microscopy of the cornea using the Heidelberg retinal tomograph cornea module. The glaucoma group was divided into two subgroups, ie, patients on medical treatment for at least two years before inclusion (with beta-blockers or prostaglandin analogs) and nontreated glaucoma patients. The following corneal parameters were evaluated: endothelial cell density and number, reflectivity, and tortuosity of sub-basal nerves. For reflectivity and tortuosity, a dedicated grading scale ranging from 0 to 4 was used. Differences between treatments were also evaluated in the treated glaucoma group.Results: Number of fibers and reflectivity of the sub-basal plexus were significantly lower in glaucoma patients as compared with controls (2.5 &plusmn; 0.7 versus 2.9 &plusmn; 0.9, P = 0.006, and 2.3 &plusmn; 0.8 versus 2.7 &plusmn; 0.9, P = 0.04, respectively), whereas tortuosity was significantly higher (2.6 &plusmn; 1 versus 2.0 &plusmn; 0.8, P = 0.007). Endothelial cell density (measured as cells per mm2) was lower in the glaucoma group comparing treated patients with nontreated patients (2826 &plusmn; 285 versus 3124 &plusmn; 272, P = 0.0003). Comparing treated patients with nontreated patients, relevant differences were found in number (2.3 &plusmn; 0.7 versus 2.8 &plusmn; 0.8, P = 0.004), tortuosity (2.8 &plusmn; 1 versus 2.2 &plusmn; 0.8, P = 0.004), and reflectivity (2.2 &plusmn; 0.8 versus 2.6 &plusmn; 0.8, P = 0.04). No differences in corneal parameters were found between beta-blockers and prostaglandin analogs.Conclusion: This study shows that differences in corneal parameters between glaucoma patients and controls may be due to the medical treatments used for glaucoma. These data should be taken into consideration in long-standing medical glaucoma treatment and in potential candidates for surgery.Keywords: cornea, glaucoma, sub-basal nerves, endothelial cells, confocal microscopy&nbsp;
format	article
author	Ranno S Fogagnolo P Rossetti L Orzalesi N Nucci P
author_facet	Ranno S Fogagnolo P Rossetti L Orzalesi N Nucci P
author_sort	Ranno S
title	Changes in corneal parameters at confocal microscopy in treated glaucoma patients
title_short	Changes in corneal parameters at confocal microscopy in treated glaucoma patients
title_full	Changes in corneal parameters at confocal microscopy in treated glaucoma patients
title_fullStr	Changes in corneal parameters at confocal microscopy in treated glaucoma patients
title_full_unstemmed	Changes in corneal parameters at confocal microscopy in treated glaucoma patients
title_sort	changes in corneal parameters at confocal microscopy in treated glaucoma patients
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/335bf70a4f034635a6b3d5b0d738579c
work_keys_str_mv	AT rannos changesincornealparametersatconfocalmicroscopyintreatedglaucomapatients AT fogagnolop changesincornealparametersatconfocalmicroscopyintreatedglaucomapatients AT rossettil changesincornealparametersatconfocalmicroscopyintreatedglaucomapatients AT orzalesin changesincornealparametersatconfocalmicroscopyintreatedglaucomapatients AT nuccip changesincornealparametersatconfocalmicroscopyintreatedglaucomapatients
_version_	1718395869604085760

Changes in corneal parameters at confocal microscopy in treated glaucoma patients

Ejemplares similares