In Silico/In Vitro Strategies Leading to the Discovery of New Nonribosomal Peptide and Polyketide Antibiotics Active against Human Pathogens

Antibiotics are majorly important molecules for human health. Following the golden age of antibiotic discovery, a period of decline ensued, characterised by the rediscovery of the same molecules. At the same time, new culture techniques and high-throughput sequencing enabled the discovery of new mic...

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Autores principales:	Sami Khabthani, Jean-Marc Rolain, Vicky Merhej
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	new NRP-PK antibiotics in silico/in vitro strategies human pathogens bottom-up approach Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/335c42cedcb44aabae4c02720d7eadaf
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spelling	oai:doaj.org-article:335c42cedcb44aabae4c02720d7eadaf2021-11-25T18:24:55ZIn Silico/In Vitro Strategies Leading to the Discovery of New Nonribosomal Peptide and Polyketide Antibiotics Active against Human Pathogens10.3390/microorganisms91122972076-2607https://doaj.org/article/335c42cedcb44aabae4c02720d7eadaf2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-2607/9/11/2297https://doaj.org/toc/2076-2607Antibiotics are majorly important molecules for human health. Following the golden age of antibiotic discovery, a period of decline ensued, characterised by the rediscovery of the same molecules. At the same time, new culture techniques and high-throughput sequencing enabled the discovery of new microorganisms that represent a potential source of interesting new antimicrobial substances to explore. The aim of this review is to present recently discovered nonribosomal peptide (NRP) and polyketide (PK) molecules with antimicrobial activity against human pathogens. We highlight the different in silico/in vitro strategies and approaches that led to their discovery. As a result of technological progress and a better understanding of the NRP and PK synthesis mechanisms, these new antibiotic compounds provide an additional option in human medical treatment and a potential way out of the impasse of antibiotic resistance.Sami KhabthaniJean-Marc RolainVicky MerhejMDPI AGarticlenew NRP-PK antibioticsin silico/in vitro strategieshuman pathogensbottom-up approachBiology (General)QH301-705.5ENMicroorganisms, Vol 9, Iss 2297, p 2297 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	new NRP-PK antibiotics in silico/in vitro strategies human pathogens bottom-up approach Biology (General) QH301-705.5
spellingShingle	new NRP-PK antibiotics in silico/in vitro strategies human pathogens bottom-up approach Biology (General) QH301-705.5 Sami Khabthani Jean-Marc Rolain Vicky Merhej In Silico/In Vitro Strategies Leading to the Discovery of New Nonribosomal Peptide and Polyketide Antibiotics Active against Human Pathogens
description	Antibiotics are majorly important molecules for human health. Following the golden age of antibiotic discovery, a period of decline ensued, characterised by the rediscovery of the same molecules. At the same time, new culture techniques and high-throughput sequencing enabled the discovery of new microorganisms that represent a potential source of interesting new antimicrobial substances to explore. The aim of this review is to present recently discovered nonribosomal peptide (NRP) and polyketide (PK) molecules with antimicrobial activity against human pathogens. We highlight the different in silico/in vitro strategies and approaches that led to their discovery. As a result of technological progress and a better understanding of the NRP and PK synthesis mechanisms, these new antibiotic compounds provide an additional option in human medical treatment and a potential way out of the impasse of antibiotic resistance.
format	article
author	Sami Khabthani Jean-Marc Rolain Vicky Merhej
author_facet	Sami Khabthani Jean-Marc Rolain Vicky Merhej
author_sort	Sami Khabthani
title	In Silico/In Vitro Strategies Leading to the Discovery of New Nonribosomal Peptide and Polyketide Antibiotics Active against Human Pathogens
title_short	In Silico/In Vitro Strategies Leading to the Discovery of New Nonribosomal Peptide and Polyketide Antibiotics Active against Human Pathogens
title_full	In Silico/In Vitro Strategies Leading to the Discovery of New Nonribosomal Peptide and Polyketide Antibiotics Active against Human Pathogens
title_fullStr	In Silico/In Vitro Strategies Leading to the Discovery of New Nonribosomal Peptide and Polyketide Antibiotics Active against Human Pathogens
title_full_unstemmed	In Silico/In Vitro Strategies Leading to the Discovery of New Nonribosomal Peptide and Polyketide Antibiotics Active against Human Pathogens
title_sort	in silico/in vitro strategies leading to the discovery of new nonribosomal peptide and polyketide antibiotics active against human pathogens
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/335c42cedcb44aabae4c02720d7eadaf
work_keys_str_mv	AT samikhabthani insilicoinvitrostrategiesleadingtothediscoveryofnewnonribosomalpeptideandpolyketideantibioticsactiveagainsthumanpathogens AT jeanmarcrolain insilicoinvitrostrategiesleadingtothediscoveryofnewnonribosomalpeptideandpolyketideantibioticsactiveagainsthumanpathogens AT vickymerhej insilicoinvitrostrategiesleadingtothediscoveryofnewnonribosomalpeptideandpolyketideantibioticsactiveagainsthumanpathogens
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In Silico/In Vitro Strategies Leading to the Discovery of New Nonribosomal Peptide and Polyketide Antibiotics Active against Human Pathogens

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