Matrix degradability controls multicellularity of 3D cell migration

The fabrication of vascularized 3D tissues requires an understanding of how material properties govern endothelial cell invasion into the surrounding matrix. Here the authors integrate a non-swelling synthetic hydrogel with a microfluidic device to study chemokine gradient-driven angiogenic sproutin...

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Autores principales:	Britta Trappmann, Brendon M. Baker, William J. Polacheck, Colin K. Choi, Jason A. Burdick, Christopher S. Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/335d95b70c154450b481fc790c3be92a
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spelling	oai:doaj.org-article:335d95b70c154450b481fc790c3be92a2021-12-02T14:40:33ZMatrix degradability controls multicellularity of 3D cell migration10.1038/s41467-017-00418-62041-1723https://doaj.org/article/335d95b70c154450b481fc790c3be92a2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00418-6https://doaj.org/toc/2041-1723The fabrication of vascularized 3D tissues requires an understanding of how material properties govern endothelial cell invasion into the surrounding matrix. Here the authors integrate a non-swelling synthetic hydrogel with a microfluidic device to study chemokine gradient-driven angiogenic sprouting and find that matrix degradability modulates the collectivity of cell migration.Britta TrappmannBrendon M. BakerWilliam J. PolacheckColin K. ChoiJason A. BurdickChristopher S. ChenNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Britta Trappmann Brendon M. Baker William J. Polacheck Colin K. Choi Jason A. Burdick Christopher S. Chen Matrix degradability controls multicellularity of 3D cell migration
description	The fabrication of vascularized 3D tissues requires an understanding of how material properties govern endothelial cell invasion into the surrounding matrix. Here the authors integrate a non-swelling synthetic hydrogel with a microfluidic device to study chemokine gradient-driven angiogenic sprouting and find that matrix degradability modulates the collectivity of cell migration.
format	article
author	Britta Trappmann Brendon M. Baker William J. Polacheck Colin K. Choi Jason A. Burdick Christopher S. Chen
author_facet	Britta Trappmann Brendon M. Baker William J. Polacheck Colin K. Choi Jason A. Burdick Christopher S. Chen
author_sort	Britta Trappmann
title	Matrix degradability controls multicellularity of 3D cell migration
title_short	Matrix degradability controls multicellularity of 3D cell migration
title_full	Matrix degradability controls multicellularity of 3D cell migration
title_fullStr	Matrix degradability controls multicellularity of 3D cell migration
title_full_unstemmed	Matrix degradability controls multicellularity of 3D cell migration
title_sort	matrix degradability controls multicellularity of 3d cell migration
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/335d95b70c154450b481fc790c3be92a
work_keys_str_mv	AT brittatrappmann matrixdegradabilitycontrolsmulticellularityof3dcellmigration AT brendonmbaker matrixdegradabilitycontrolsmulticellularityof3dcellmigration AT williamjpolacheck matrixdegradabilitycontrolsmulticellularityof3dcellmigration AT colinkchoi matrixdegradabilitycontrolsmulticellularityof3dcellmigration AT jasonaburdick matrixdegradabilitycontrolsmulticellularityof3dcellmigration AT christopherschen matrixdegradabilitycontrolsmulticellularityof3dcellmigration
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Matrix degradability controls multicellularity of 3D cell migration

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