Radionuclide-Based Imaging of Breast Cancer: State of the Art

Breast cancer is a malignant tumor that can affect women worldwide and endanger their health and wellbeing. Early detection of breast cancer can significantly improve the prognosis and survival rate of patients, but with traditional anatomical imagine methods, it is difficult to detect lesions befor...

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Autores principales:	Huiling Li, Zhen Liu, Lujie Yuan, Kevin Fan, Yongxue Zhang, Weibo Cai, Xiaoli Lan
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	breast cancer radionuclide molecular imaging positron emission tomography (PET) single-photon emission computed tomography (SPECT) Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/3360c0c54a304e0ab4932e1893bf79ac
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spelling	oai:doaj.org-article:3360c0c54a304e0ab4932e1893bf79ac2021-11-11T15:33:31ZRadionuclide-Based Imaging of Breast Cancer: State of the Art10.3390/cancers132154592072-6694https://doaj.org/article/3360c0c54a304e0ab4932e1893bf79ac2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5459https://doaj.org/toc/2072-6694Breast cancer is a malignant tumor that can affect women worldwide and endanger their health and wellbeing. Early detection of breast cancer can significantly improve the prognosis and survival rate of patients, but with traditional anatomical imagine methods, it is difficult to detect lesions before morphological changes occur. Radionuclide-based molecular imaging based on positron emission tomography (PET) and single-photon emission computed tomography (SPECT) displays its advantages for detecting breast cancer from a functional perspective. Radionuclide labeling of small metabolic compounds can be used for imaging biological processes, while radionuclide labeling of ligands/antibodies can be used for imaging receptors. Noninvasive visualization of biological processes helps elucidate the metabolic state of breast cancer, while receptor-targeted radionuclide molecular imaging is sensitive and specific for visualization of the overexpressed molecular markers in breast cancer, contributing to early diagnosis and better management of cancer patients. The rapid development of radionuclide probes aids the diagnosis of breast cancer in various aspects. These probes target metabolism, amino acid transporters, cell proliferation, hypoxia, estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), gastrin-releasing peptide receptor (GRPR) and so on. This article provides an overview of the development of radionuclide molecular imaging techniques present in preclinical or clinical studies, which are used as tools for early breast cancer diagnosis.Huiling LiZhen LiuLujie YuanKevin FanYongxue ZhangWeibo CaiXiaoli LanMDPI AGarticlebreast cancerradionuclidemolecular imagingpositron emission tomography (PET)single-photon emission computed tomography (SPECT)Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5459, p 5459 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	breast cancer radionuclide molecular imaging positron emission tomography (PET) single-photon emission computed tomography (SPECT) Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	breast cancer radionuclide molecular imaging positron emission tomography (PET) single-photon emission computed tomography (SPECT) Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Huiling Li Zhen Liu Lujie Yuan Kevin Fan Yongxue Zhang Weibo Cai Xiaoli Lan Radionuclide-Based Imaging of Breast Cancer: State of the Art
description	Breast cancer is a malignant tumor that can affect women worldwide and endanger their health and wellbeing. Early detection of breast cancer can significantly improve the prognosis and survival rate of patients, but with traditional anatomical imagine methods, it is difficult to detect lesions before morphological changes occur. Radionuclide-based molecular imaging based on positron emission tomography (PET) and single-photon emission computed tomography (SPECT) displays its advantages for detecting breast cancer from a functional perspective. Radionuclide labeling of small metabolic compounds can be used for imaging biological processes, while radionuclide labeling of ligands/antibodies can be used for imaging receptors. Noninvasive visualization of biological processes helps elucidate the metabolic state of breast cancer, while receptor-targeted radionuclide molecular imaging is sensitive and specific for visualization of the overexpressed molecular markers in breast cancer, contributing to early diagnosis and better management of cancer patients. The rapid development of radionuclide probes aids the diagnosis of breast cancer in various aspects. These probes target metabolism, amino acid transporters, cell proliferation, hypoxia, estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), gastrin-releasing peptide receptor (GRPR) and so on. This article provides an overview of the development of radionuclide molecular imaging techniques present in preclinical or clinical studies, which are used as tools for early breast cancer diagnosis.
format	article
author	Huiling Li Zhen Liu Lujie Yuan Kevin Fan Yongxue Zhang Weibo Cai Xiaoli Lan
author_facet	Huiling Li Zhen Liu Lujie Yuan Kevin Fan Yongxue Zhang Weibo Cai Xiaoli Lan
author_sort	Huiling Li
title	Radionuclide-Based Imaging of Breast Cancer: State of the Art
title_short	Radionuclide-Based Imaging of Breast Cancer: State of the Art
title_full	Radionuclide-Based Imaging of Breast Cancer: State of the Art
title_fullStr	Radionuclide-Based Imaging of Breast Cancer: State of the Art
title_full_unstemmed	Radionuclide-Based Imaging of Breast Cancer: State of the Art
title_sort	radionuclide-based imaging of breast cancer: state of the art
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3360c0c54a304e0ab4932e1893bf79ac
work_keys_str_mv	AT huilingli radionuclidebasedimagingofbreastcancerstateoftheart AT zhenliu radionuclidebasedimagingofbreastcancerstateoftheart AT lujieyuan radionuclidebasedimagingofbreastcancerstateoftheart AT kevinfan radionuclidebasedimagingofbreastcancerstateoftheart AT yongxuezhang radionuclidebasedimagingofbreastcancerstateoftheart AT weibocai radionuclidebasedimagingofbreastcancerstateoftheart AT xiaolilan radionuclidebasedimagingofbreastcancerstateoftheart
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Radionuclide-Based Imaging of Breast Cancer: State of the Art

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