Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion

Dysfunction in insulin secretion is a main driver of type 2 diabetes development. Here the authors monitor phosphoproteome modulation in cells stimulated with glucose and treated with drugs affecting glucose-mediated insulin secretion to reveal phosphorylation sites implicated in insulin secretion c...

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Autores principales:	Francesca Sacco, Sean J. Humphrey, Jürgen Cox, Marcel Mischnik, Anke Schulte, Thomas Klabunde, Matthias Schäfer, Matthias Mann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3361cb00241f44baab7bbae3776530c4
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spelling	oai:doaj.org-article:3361cb00241f44baab7bbae3776530c42021-12-02T17:32:07ZGlucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion10.1038/ncomms132502041-1723https://doaj.org/article/3361cb00241f44baab7bbae3776530c42016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13250https://doaj.org/toc/2041-1723Dysfunction in insulin secretion is a main driver of type 2 diabetes development. Here the authors monitor phosphoproteome modulation in cells stimulated with glucose and treated with drugs affecting glucose-mediated insulin secretion to reveal phosphorylation sites implicated in insulin secretion control and gene expression regulation.Francesca SaccoSean J. HumphreyJürgen CoxMarcel MischnikAnke SchulteThomas KlabundeMatthias SchäferMatthias MannNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Francesca Sacco Sean J. Humphrey Jürgen Cox Marcel Mischnik Anke Schulte Thomas Klabunde Matthias Schäfer Matthias Mann Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion
description	Dysfunction in insulin secretion is a main driver of type 2 diabetes development. Here the authors monitor phosphoproteome modulation in cells stimulated with glucose and treated with drugs affecting glucose-mediated insulin secretion to reveal phosphorylation sites implicated in insulin secretion control and gene expression regulation.
format	article
author	Francesca Sacco Sean J. Humphrey Jürgen Cox Marcel Mischnik Anke Schulte Thomas Klabunde Matthias Schäfer Matthias Mann
author_facet	Francesca Sacco Sean J. Humphrey Jürgen Cox Marcel Mischnik Anke Schulte Thomas Klabunde Matthias Schäfer Matthias Mann
author_sort	Francesca Sacco
title	Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion
title_short	Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion
title_full	Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion
title_fullStr	Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion
title_full_unstemmed	Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion
title_sort	glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/3361cb00241f44baab7bbae3776530c4
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Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion

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