T cells in the brain may contribute to attenuation of sepsis-associated depression

Sepsis-associated encephalopathy, as well as increasing mortality, has been associated with long-lasting depressive behaviour, which is thought to be caused by infection-induced neuroinflammation in the brain. Saito et al. have recently demonstrated in a mouse model of sepsis that infiltrated regula...

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Autor principal:	Karli Montague-Cardoso
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/336234e2d3b2466d853bd573adbed096
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spelling	oai:doaj.org-article:336234e2d3b2466d853bd573adbed0962021-12-02T17:05:10ZT cells in the brain may contribute to attenuation of sepsis-associated depression10.1038/s42003-021-01923-72399-3642https://doaj.org/article/336234e2d3b2466d853bd573adbed0962021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01923-7https://doaj.org/toc/2399-3642Sepsis-associated encephalopathy, as well as increasing mortality, has been associated with long-lasting depressive behaviour, which is thought to be caused by infection-induced neuroinflammation in the brain. Saito et al. have recently demonstrated in a mouse model of sepsis that infiltrated regulatory T cells in the cerebral cortex mediate the resolution of neuroinflammation and alleviate anxious/depressive behaviour. Their study paves the way for further research that investigates the role of T cells in the underlying mechanisms mediating recovery of sepsis-associated depression.Karli Montague-CardosoNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-2 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Karli Montague-Cardoso T cells in the brain may contribute to attenuation of sepsis-associated depression
description	Sepsis-associated encephalopathy, as well as increasing mortality, has been associated with long-lasting depressive behaviour, which is thought to be caused by infection-induced neuroinflammation in the brain. Saito et al. have recently demonstrated in a mouse model of sepsis that infiltrated regulatory T cells in the cerebral cortex mediate the resolution of neuroinflammation and alleviate anxious/depressive behaviour. Their study paves the way for further research that investigates the role of T cells in the underlying mechanisms mediating recovery of sepsis-associated depression.
format	article
author	Karli Montague-Cardoso
author_facet	Karli Montague-Cardoso
author_sort	Karli Montague-Cardoso
title	T cells in the brain may contribute to attenuation of sepsis-associated depression
title_short	T cells in the brain may contribute to attenuation of sepsis-associated depression
title_full	T cells in the brain may contribute to attenuation of sepsis-associated depression
title_fullStr	T cells in the brain may contribute to attenuation of sepsis-associated depression
title_full_unstemmed	T cells in the brain may contribute to attenuation of sepsis-associated depression
title_sort	t cells in the brain may contribute to attenuation of sepsis-associated depression
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/336234e2d3b2466d853bd573adbed096
work_keys_str_mv	AT karlimontaguecardoso tcellsinthebrainmaycontributetoattenuationofsepsisassociateddepression
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T cells in the brain may contribute to attenuation of sepsis-associated depression

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