Reduced Sleep in the Week Prior to Diagnosis of COVID-19 is Associated with the Severity of COVID-19

Baozhen Huang,1 Yanlin Niu,2 Weiguo Zhao,3 Pengtao Bao,4 Diangeng Li1,5 1Nanlou Respiratory Diseases Department, 2nd Medical Center of Chinese PLA General Hospital, Beijing, People’s Republic of China; 2Beijing Center for Disease Prevention and Control, Institute for Nutrition and Food Hyg...

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Autores principales:	Huang B, Niu Y, Zhao W, Bao P, Li D
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	covid-19 disease severity sleep status damage of external lung organs Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/33638bda91ca437f89886f94c34020c4
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spelling	oai:doaj.org-article:33638bda91ca437f89886f94c34020c42021-12-02T12:13:47ZReduced Sleep in the Week Prior to Diagnosis of COVID-19 is Associated with the Severity of COVID-191179-1608https://doaj.org/article/33638bda91ca437f89886f94c34020c42020-11-01T00:00:00Zhttps://www.dovepress.com/reduced-sleep-in-the-week-prior-to-diagnosis-of-covid-19-is-associated-peer-reviewed-article-NSShttps://doaj.org/toc/1179-1608Baozhen Huang,1 Yanlin Niu,2 Weiguo Zhao,3 Pengtao Bao,4 Diangeng Li1,5 1Nanlou Respiratory Diseases Department, 2nd Medical Center of Chinese PLA General Hospital, Beijing, People’s Republic of China; 2Beijing Center for Disease Prevention and Control, Institute for Nutrition and Food Hygiene, Beijing, People’s Republic of China; 3Department of Respiratory Medicine, The Eighth Medical Center of Chinese PLA General Hospital, Beijing, People’s Republic of China; 4Department of Pulmonary and Critical Care Medicine, The Eighth Medical Center of Chinese, Beijing, People’s Republic of China; 5Department of Nephrology, Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing, People’s Republic of ChinaCorrespondence: Diangeng LiNanlou Respiratory Diseases Department, 2nd Medical Center of Chinese PLA General Hospital, 28th Fuxing Road, Beijing 100853, People’s Republic of ChinaEmail lidiangeng@126.comPengtao BaoDepartment of Pulmonary and Critical Care Medicine, The Eighth Medical Center of Chinese PLA General Hospital, 17th Heishanhu Road, Beijing 100093, People’s Republic of ChinaEmail bao03@163.comBackground: The rapid outbreak of coronavirus disease 2019 (COVID-19) is a major health concern, in response to which widespread risk factor research is being carried out.Objective: To discover how physical activity and lifestyle affect the epidemic as well as the disease severity and prognosis of COVID-19 patients.Methods: This multicenter, retrospective cohort study included 203 adults infected with COVID-19 and 228 uninfected adults in three Chinese provinces, with 164 (80.7%) of the infected participants and 188 (82.5%) of the uninfected participants answering a doctor-administered telephone questionnaire on lifestyle. The binary logistic regression model and the ordinal logit model were used to observe relevance.Results: Comparing sick and non-sick patients, we found that irregular exercise (P=0.004), sedentary lifestyle (P=0.010), and overexertion (P< 0.001) may be associated with the susceptibility to COVID-19. In symptomatic patients, using the recommended status as a reference, risk of severe infection increased with decreased sleep status, being 6.729 (95% CI=2.138– 21.181) times higher for potentially appropriate sleep (P=0.001) and peaking at 8.612 (95% CI=1.913– 38.760) times higher for lack of sleep (P=0.005). Reduction in average daily sleep time significantly increased the likely severity (P=0.002).Discussion: Through further examination of damage of external lung organs, we found that lack of sleep affected not only disease severity but also prognosis. Based on these findings, the public should prioritize a healthy lifestyle and get adequate sleep in response to the outbreak. The study of life habits may bring new ideas for the prevention and treatment of COVID-19.Keywords: COVID-19, disease severity, sleep status, damage of external lung organsHuang BNiu YZhao WBao PLi DDove Medical Pressarticlecovid-19disease severitysleep statusdamage of external lung organsPsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol Volume 12, Pp 999-1007 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	covid-19 disease severity sleep status damage of external lung organs Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	covid-19 disease severity sleep status damage of external lung organs Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Huang B Niu Y Zhao W Bao P Li D Reduced Sleep in the Week Prior to Diagnosis of COVID-19 is Associated with the Severity of COVID-19
description	Baozhen Huang,1 Yanlin Niu,2 Weiguo Zhao,3 Pengtao Bao,4 Diangeng Li1,5 1Nanlou Respiratory Diseases Department, 2nd Medical Center of Chinese PLA General Hospital, Beijing, People’s Republic of China; 2Beijing Center for Disease Prevention and Control, Institute for Nutrition and Food Hygiene, Beijing, People’s Republic of China; 3Department of Respiratory Medicine, The Eighth Medical Center of Chinese PLA General Hospital, Beijing, People’s Republic of China; 4Department of Pulmonary and Critical Care Medicine, The Eighth Medical Center of Chinese, Beijing, People’s Republic of China; 5Department of Nephrology, Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing, People’s Republic of ChinaCorrespondence: Diangeng LiNanlou Respiratory Diseases Department, 2nd Medical Center of Chinese PLA General Hospital, 28th Fuxing Road, Beijing 100853, People’s Republic of ChinaEmail lidiangeng@126.comPengtao BaoDepartment of Pulmonary and Critical Care Medicine, The Eighth Medical Center of Chinese PLA General Hospital, 17th Heishanhu Road, Beijing 100093, People’s Republic of ChinaEmail bao03@163.comBackground: The rapid outbreak of coronavirus disease 2019 (COVID-19) is a major health concern, in response to which widespread risk factor research is being carried out.Objective: To discover how physical activity and lifestyle affect the epidemic as well as the disease severity and prognosis of COVID-19 patients.Methods: This multicenter, retrospective cohort study included 203 adults infected with COVID-19 and 228 uninfected adults in three Chinese provinces, with 164 (80.7%) of the infected participants and 188 (82.5%) of the uninfected participants answering a doctor-administered telephone questionnaire on lifestyle. The binary logistic regression model and the ordinal logit model were used to observe relevance.Results: Comparing sick and non-sick patients, we found that irregular exercise (P=0.004), sedentary lifestyle (P=0.010), and overexertion (P< 0.001) may be associated with the susceptibility to COVID-19. In symptomatic patients, using the recommended status as a reference, risk of severe infection increased with decreased sleep status, being 6.729 (95% CI=2.138– 21.181) times higher for potentially appropriate sleep (P=0.001) and peaking at 8.612 (95% CI=1.913– 38.760) times higher for lack of sleep (P=0.005). Reduction in average daily sleep time significantly increased the likely severity (P=0.002).Discussion: Through further examination of damage of external lung organs, we found that lack of sleep affected not only disease severity but also prognosis. Based on these findings, the public should prioritize a healthy lifestyle and get adequate sleep in response to the outbreak. The study of life habits may bring new ideas for the prevention and treatment of COVID-19.Keywords: COVID-19, disease severity, sleep status, damage of external lung organs
format	article
author	Huang B Niu Y Zhao W Bao P Li D
author_facet	Huang B Niu Y Zhao W Bao P Li D
author_sort	Huang B
title	Reduced Sleep in the Week Prior to Diagnosis of COVID-19 is Associated with the Severity of COVID-19
title_short	Reduced Sleep in the Week Prior to Diagnosis of COVID-19 is Associated with the Severity of COVID-19
title_full	Reduced Sleep in the Week Prior to Diagnosis of COVID-19 is Associated with the Severity of COVID-19
title_fullStr	Reduced Sleep in the Week Prior to Diagnosis of COVID-19 is Associated with the Severity of COVID-19
title_full_unstemmed	Reduced Sleep in the Week Prior to Diagnosis of COVID-19 is Associated with the Severity of COVID-19
title_sort	reduced sleep in the week prior to diagnosis of covid-19 is associated with the severity of covid-19
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/33638bda91ca437f89886f94c34020c4
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Reduced Sleep in the Week Prior to Diagnosis of COVID-19 is Associated with the Severity of COVID-19

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