Pulsing blue light through closed eyelids: effects on acute melatonin suppression and phase shifting of dim light melatonin onset

Mariana G Figueiro, Barbara Plitnick, Mark S Rea Lighting Research Center, Rensselaer Polytechnic Institute, Troy, NY, USA Abstract: Circadian rhythm disturbances parallel the increased prevalence of sleep disorders in older adults. Light therapies that specifically target regulation of the circad...

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Autores principales:	Figueiro MG, Plitnick B, Rea MS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/3363fa6574e2483988c45132f7af4fff
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spelling	oai:doaj.org-article:3363fa6574e2483988c45132f7af4fff2021-12-02T08:34:05ZPulsing blue light through closed eyelids: effects on acute melatonin suppression and phase shifting of dim light melatonin onset1179-1608https://doaj.org/article/3363fa6574e2483988c45132f7af4fff2014-12-01T00:00:00Zhttp://www.dovepress.com/pulsing-blue-light-through-closed-eyelids-effects-on-acute-melatonin-s-peer-reviewed-article-NSShttps://doaj.org/toc/1179-1608 Mariana G Figueiro, Barbara Plitnick, Mark S Rea Lighting Research Center, Rensselaer Polytechnic Institute, Troy, NY, USA Abstract: Circadian rhythm disturbances parallel the increased prevalence of sleep disorders in older adults. Light therapies that specifically target regulation of the circadian system in principle could be used to treat sleep disorders in this population. Current recommendations for light treatment require the patients to sit in front of a bright light box for at least 1 hour daily, perhaps limiting their willingness to comply. Light applied through closed eyelids during sleep might not only be efficacious for changing circadian phase but also lead to better compliance because patients would receive light treatment while sleeping. Reported here are the results of two studies investigating the impact of a train of 480 nm (blue) light pulses presented to the retina through closed eyelids on melatonin suppression (laboratory study) and on delaying circadian phase (field study). Both studies employed a sleep mask that provided narrowband blue light pulses of 2-second duration every 30 seconds from arrays of light-emitting diodes. The results of the laboratory study demonstrated that the blue light pulses significantly suppressed melatonin by an amount similar to that previously shown in the same protocol at half the frequency (ie, one 2-second pulse every minute for 1 hour). The results of the field study demonstrated that blue light pulses given early in the sleep episode significantly delayed circadian phase in older adults; these results are the first to demonstrate the efficacy and practicality of light treatment by a sleep mask aimed at adjusting circadian phase in a home setting. Keywords: circadian phase, dim light melatonin onset, light through closed eyelids, blue light, sleepFigueiro MGPlitnick BRea MSDove Medical PressarticlePsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol 2014, Iss default, Pp 149-156 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Figueiro MG Plitnick B Rea MS Pulsing blue light through closed eyelids: effects on acute melatonin suppression and phase shifting of dim light melatonin onset
description	Mariana G Figueiro, Barbara Plitnick, Mark S Rea Lighting Research Center, Rensselaer Polytechnic Institute, Troy, NY, USA Abstract: Circadian rhythm disturbances parallel the increased prevalence of sleep disorders in older adults. Light therapies that specifically target regulation of the circadian system in principle could be used to treat sleep disorders in this population. Current recommendations for light treatment require the patients to sit in front of a bright light box for at least 1 hour daily, perhaps limiting their willingness to comply. Light applied through closed eyelids during sleep might not only be efficacious for changing circadian phase but also lead to better compliance because patients would receive light treatment while sleeping. Reported here are the results of two studies investigating the impact of a train of 480 nm (blue) light pulses presented to the retina through closed eyelids on melatonin suppression (laboratory study) and on delaying circadian phase (field study). Both studies employed a sleep mask that provided narrowband blue light pulses of 2-second duration every 30 seconds from arrays of light-emitting diodes. The results of the laboratory study demonstrated that the blue light pulses significantly suppressed melatonin by an amount similar to that previously shown in the same protocol at half the frequency (ie, one 2-second pulse every minute for 1 hour). The results of the field study demonstrated that blue light pulses given early in the sleep episode significantly delayed circadian phase in older adults; these results are the first to demonstrate the efficacy and practicality of light treatment by a sleep mask aimed at adjusting circadian phase in a home setting. Keywords: circadian phase, dim light melatonin onset, light through closed eyelids, blue light, sleep
format	article
author	Figueiro MG Plitnick B Rea MS
author_facet	Figueiro MG Plitnick B Rea MS
author_sort	Figueiro MG
title	Pulsing blue light through closed eyelids: effects on acute melatonin suppression and phase shifting of dim light melatonin onset
title_short	Pulsing blue light through closed eyelids: effects on acute melatonin suppression and phase shifting of dim light melatonin onset
title_full	Pulsing blue light through closed eyelids: effects on acute melatonin suppression and phase shifting of dim light melatonin onset
title_fullStr	Pulsing blue light through closed eyelids: effects on acute melatonin suppression and phase shifting of dim light melatonin onset
title_full_unstemmed	Pulsing blue light through closed eyelids: effects on acute melatonin suppression and phase shifting of dim light melatonin onset
title_sort	pulsing blue light through closed eyelids: effects on acute melatonin suppression and phase shifting of dim light melatonin onset
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/3363fa6574e2483988c45132f7af4fff
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Pulsing blue light through closed eyelids: effects on acute melatonin suppression and phase shifting of dim light melatonin onset

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