Low Branched Chain Amino Acids and Tyrosine in Thai Patients with Type 2 Diabetes Mellitus Treated with Metformin and Metformin-Sulfonylurea Combination Therapies

Type 2 diabetes mellitus (T2DM) is a growing public health challenge for Thailand (current prevalence ~10.0%). Amino acids offer novel biomarkers to predict risk of T2DM and indicate sub-optimal disease management, which could facilitate earlier treatment. We studied amino acid profiles in a Thai co...

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Autores principales:	Natthida Sriboonvorakul, Wirichada Pan-Ngum, Kittiyod Poovorawan, Sant Muangnoicharoen, Lauren M. Quinn, Bee K. Tan
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	amino acids liquid chromatography-mass spectrometry LC-MS metformin sulfonyl-urea type 2 diabetes mellitus Medicine R
Acceso en línea:	https://doaj.org/article/336510872e754ef4b1c689a26b81bf1a
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spelling	oai:doaj.org-article:336510872e754ef4b1c689a26b81bf1a2021-11-25T18:02:40ZLow Branched Chain Amino Acids and Tyrosine in Thai Patients with Type 2 Diabetes Mellitus Treated with Metformin and Metformin-Sulfonylurea Combination Therapies10.3390/jcm102254242077-0383https://doaj.org/article/336510872e754ef4b1c689a26b81bf1a2021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5424https://doaj.org/toc/2077-0383Type 2 diabetes mellitus (T2DM) is a growing public health challenge for Thailand (current prevalence ~10.0%). Amino acids offer novel biomarkers to predict risk of T2DM and indicate sub-optimal disease management, which could facilitate earlier treatment. We studied amino acid profiles in a Thai cohort comprising of individuals with T2DM (<i>n</i> = 65 single-drug-treated; <i>n</i> = 38 multi-drug-treated) compared to healthy controls (<i>n</i> = 104) using liquid chromatography-mass spectrometry. Age and BMI were significantly lower in the healthy controls compared to the single or multi-treated T2DM groups. The BCAA (leucine and valine) were significantly lower in the single and multi-treated T2DM groups compared to healthy controls (<i>p</i> < 0.001 and <i>p</i> < 0.001) and isoleucine was significantly lower in the single-treated compared to the healthy controls (<i>p</i> = 0.014). These findings beg the question whether BCAAs supplementation be beneficial in T2DM patients treated with single or multi-drug therapy? Tyrosine was significantly lower in the single and multi-treated T2DM groups compared to healthy controls (<i>p</i> < 0.001 and <i>p</i> = 0.002), whereas phenylalanine was significantly higher in the multi-treated T2DM group compared to the single treated T2DM group (<i>p</i> = 0.045). We provide novel insights into the effects of diabetes treatments on these amino acids in insulin resistant states such as T2DM in a unique but understudied Thai population.Natthida SriboonvorakulWirichada Pan-NgumKittiyod PoovorawanSant MuangnoicharoenLauren M. QuinnBee K. TanMDPI AGarticleamino acidsliquid chromatography-mass spectrometryLC-MSmetforminsulfonyl-ureatype 2 diabetes mellitusMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5424, p 5424 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	amino acids liquid chromatography-mass spectrometry LC-MS metformin sulfonyl-urea type 2 diabetes mellitus Medicine R
spellingShingle	amino acids liquid chromatography-mass spectrometry LC-MS metformin sulfonyl-urea type 2 diabetes mellitus Medicine R Natthida Sriboonvorakul Wirichada Pan-Ngum Kittiyod Poovorawan Sant Muangnoicharoen Lauren M. Quinn Bee K. Tan Low Branched Chain Amino Acids and Tyrosine in Thai Patients with Type 2 Diabetes Mellitus Treated with Metformin and Metformin-Sulfonylurea Combination Therapies
description	Type 2 diabetes mellitus (T2DM) is a growing public health challenge for Thailand (current prevalence ~10.0%). Amino acids offer novel biomarkers to predict risk of T2DM and indicate sub-optimal disease management, which could facilitate earlier treatment. We studied amino acid profiles in a Thai cohort comprising of individuals with T2DM (<i>n</i> = 65 single-drug-treated; <i>n</i> = 38 multi-drug-treated) compared to healthy controls (<i>n</i> = 104) using liquid chromatography-mass spectrometry. Age and BMI were significantly lower in the healthy controls compared to the single or multi-treated T2DM groups. The BCAA (leucine and valine) were significantly lower in the single and multi-treated T2DM groups compared to healthy controls (<i>p</i> < 0.001 and <i>p</i> < 0.001) and isoleucine was significantly lower in the single-treated compared to the healthy controls (<i>p</i> = 0.014). These findings beg the question whether BCAAs supplementation be beneficial in T2DM patients treated with single or multi-drug therapy? Tyrosine was significantly lower in the single and multi-treated T2DM groups compared to healthy controls (<i>p</i> < 0.001 and <i>p</i> = 0.002), whereas phenylalanine was significantly higher in the multi-treated T2DM group compared to the single treated T2DM group (<i>p</i> = 0.045). We provide novel insights into the effects of diabetes treatments on these amino acids in insulin resistant states such as T2DM in a unique but understudied Thai population.
format	article
author	Natthida Sriboonvorakul Wirichada Pan-Ngum Kittiyod Poovorawan Sant Muangnoicharoen Lauren M. Quinn Bee K. Tan
author_facet	Natthida Sriboonvorakul Wirichada Pan-Ngum Kittiyod Poovorawan Sant Muangnoicharoen Lauren M. Quinn Bee K. Tan
author_sort	Natthida Sriboonvorakul
title	Low Branched Chain Amino Acids and Tyrosine in Thai Patients with Type 2 Diabetes Mellitus Treated with Metformin and Metformin-Sulfonylurea Combination Therapies
title_short	Low Branched Chain Amino Acids and Tyrosine in Thai Patients with Type 2 Diabetes Mellitus Treated with Metformin and Metformin-Sulfonylurea Combination Therapies
title_full	Low Branched Chain Amino Acids and Tyrosine in Thai Patients with Type 2 Diabetes Mellitus Treated with Metformin and Metformin-Sulfonylurea Combination Therapies
title_fullStr	Low Branched Chain Amino Acids and Tyrosine in Thai Patients with Type 2 Diabetes Mellitus Treated with Metformin and Metformin-Sulfonylurea Combination Therapies
title_full_unstemmed	Low Branched Chain Amino Acids and Tyrosine in Thai Patients with Type 2 Diabetes Mellitus Treated with Metformin and Metformin-Sulfonylurea Combination Therapies
title_sort	low branched chain amino acids and tyrosine in thai patients with type 2 diabetes mellitus treated with metformin and metformin-sulfonylurea combination therapies
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/336510872e754ef4b1c689a26b81bf1a
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Low Branched Chain Amino Acids and Tyrosine in Thai Patients with Type 2 Diabetes Mellitus Treated with Metformin and Metformin-Sulfonylurea Combination Therapies

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