SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts

Hedgehog signaling is essential for bone formation. Here, the authors show that the transmembrane protein SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts, suggesting it may be a potential therapeutic target to enhance bone formation.

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Autores principales:	Jun Sun, Dong Yeon Shin, Mark Eiseman, Alisha R. Yallowitz, Na Li, Sarfaraz Lalani, Zan Li, Michelle Cung, Seoyeon Bok, Shawon Debnath, Sofia Jenia Marquez, Tommy E. White, Abdul G. Khan, Ivo C. Lorenz, Jae-Hyuck Shim, Francis S. Lee, Ren Xu, Matthew B. Greenblatt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/336539fea16c45a5b002c405f1af2ce5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:336539fea16c45a5b002c405f1af2ce52021-12-02T16:14:36ZSLITRK5 is a negative regulator of hedgehog signaling in osteoblasts10.1038/s41467-021-24819-w2041-1723https://doaj.org/article/336539fea16c45a5b002c405f1af2ce52021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24819-whttps://doaj.org/toc/2041-1723Hedgehog signaling is essential for bone formation. Here, the authors show that the transmembrane protein SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts, suggesting it may be a potential therapeutic target to enhance bone formation.Jun SunDong Yeon ShinMark EisemanAlisha R. YallowitzNa LiSarfaraz LalaniZan LiMichelle CungSeoyeon BokShawon DebnathSofia Jenia MarquezTommy E. WhiteAbdul G. KhanIvo C. LorenzJae-Hyuck ShimFrancis S. LeeRen XuMatthew B. GreenblattNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jun Sun Dong Yeon Shin Mark Eiseman Alisha R. Yallowitz Na Li Sarfaraz Lalani Zan Li Michelle Cung Seoyeon Bok Shawon Debnath Sofia Jenia Marquez Tommy E. White Abdul G. Khan Ivo C. Lorenz Jae-Hyuck Shim Francis S. Lee Ren Xu Matthew B. Greenblatt SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts
description	Hedgehog signaling is essential for bone formation. Here, the authors show that the transmembrane protein SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts, suggesting it may be a potential therapeutic target to enhance bone formation.
format	article
author	Jun Sun Dong Yeon Shin Mark Eiseman Alisha R. Yallowitz Na Li Sarfaraz Lalani Zan Li Michelle Cung Seoyeon Bok Shawon Debnath Sofia Jenia Marquez Tommy E. White Abdul G. Khan Ivo C. Lorenz Jae-Hyuck Shim Francis S. Lee Ren Xu Matthew B. Greenblatt
author_facet	Jun Sun Dong Yeon Shin Mark Eiseman Alisha R. Yallowitz Na Li Sarfaraz Lalani Zan Li Michelle Cung Seoyeon Bok Shawon Debnath Sofia Jenia Marquez Tommy E. White Abdul G. Khan Ivo C. Lorenz Jae-Hyuck Shim Francis S. Lee Ren Xu Matthew B. Greenblatt
author_sort	Jun Sun
title	SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts
title_short	SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts
title_full	SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts
title_fullStr	SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts
title_full_unstemmed	SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts
title_sort	slitrk5 is a negative regulator of hedgehog signaling in osteoblasts
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/336539fea16c45a5b002c405f1af2ce5
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SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts

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